Browsing by Author "Tom Defoirdt"

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Bactericidal, quorum quenching and anti-biofilm nanofactories: a new niche for nanotechnologists
(Taylor and Francis Ltd, 2017) Brahma N. Singh; Prateeksha; Dalip K. Upreti; Braj Raj Singh; Tom Defoirdt; Vijai K. Gupta; Ana Olivia De Souza; Harikesh Bahadur Singh; João C. M. Barreira; Isabel C. F. R. Ferreira; Khabat Vahabi
Despite several conventional potent antibacterial therapies, bacterial infections pose a significant threat to human health because they are emerging as the leading cause of death worldwide. Due to the development of antibiotic resistance in bacteria, there is a pressing demand to discover novel approaches for developing more effective therapies to treat multidrug-resistant bacterial strains and biofilm-associated infections. Therefore, attention has been especially devoted to a new and emerging branch of science “nanotechnology” to design non-conventional antimicrobial chemotherapies. A range of nanomaterials and nano-sized carriers for conventional antimicrobial agents have fully justified their potential to combat bacterial diseases by reducing cell viability, by attenuating quorum sensing, and by inhibiting/or eradicating biofilms. This communication summarizes emerging nano-antimicrobial therapies in treating bacterial infections, particularly using antibacterial, quorum quenching, and anti-biofilm nanomaterials as new approaches to tackle the current challenges in combating infectious diseases. © 2016 Informa UK Limited, trading as Taylor & Francis Group.