Browsing by Author "Usha Dhingra"

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PRAYAS: individual patient data meta-analysis database for Pooled Research and Analysis for Yielding Anemia-free Solutions in India
(Frontiers Media SA, 2025) Anuj Kumar Pandey; Anju Pradhan Sinha; Ramu Rawat; Ranadip Chowdhury; Shivaprasad S. Goudar; Jitender Nagpal; Shrey A. Desai; Avula Laxmaiah; Basany Kalpana; Sadhana Ramchandra Joshi; Chittaranjan Sakerlal Yajnik; Aparna Mukherjee; Pratibha K. Dwarkanath; Priyanka Gupta Bansal; Molly Jacob; Shinjini Bhatnagar; Komal H. Shah; Debarati Mukherjee; Amlin Shukla; Raghu Pullakhandam; Varsha S. Dhurde; Aditi A. Apte; Rajeev Kumar Singh; Aakriti Gupta; Yamini Priyanka; Usha Dhingra; Ravi Prakash Upadhyay; Sutapa Bandyopadhyay B Neogi; Manjunath Somappa Somannavar; Anirban N. Mandal; Gayatri Desai; Shantanu Sengupta; Shailendra Dandge; Girija Narendrakumar Wagh; Urmila S. Deshmukh; Gunjan Kumar; Anura Vishwanath Kurpad; Gurudayal Singh Toteja; Nikhitha Mariya John; Shailaja Sopory; Somen Saha; Giridhar R. Babu; Anandika Suryavanshi; Ravindranadh Palika; Archana Behram Patel; Radhika K. Nimkar; Gaurav Raj Dwivedi; Umesh S. Kapil; Dilip Raja; Arup Dutta; Sunita Taneja; Diksha Gautam; Avinash Kavi; Swapnil Rawat; Kapil Dave; Rajiva Raman; Catherine L. Haggerty; Sanjay Kewalchand Lalwani; Prachi Ravindra Phadke; Alka Turuk; Tinku S. Thomas; Neena Bhatia; Manisha Madai Beck; Lovejeet Kaur; Aakansha Shukla; Ravi Deepa; Lindsey Mina Locks; Dhiraj M. Agarwal; Raja Sriswan Mamidi; Harshpal Singh Sachdev; Rounik Talukdar; Sayan Das; Nita Bhandari; Ranjana A. Singh; S. Yogeshkumar; Ramasheesh Yadav; Purushotham Sudhakar Reddy; Sanjay A. Gupte; S. Rasika Ladkat; Zaozianlungliu Gonmei; Swati Rathore; Dharmendra Sharma; Apurva Kumar Pandya; Yamuna Ana; Patricia L. Hibberd; Himangi Govind Lubree; Anwar Basha Dudekula; Priti Rishi Lal; Pearlin Amaan Khan; Aruna Verma; Umesh S. Charantimath; Indrapal Ishwarji Meshram; Karuna N. Randhir; Onkar Deshmukh; Ashok Kumar Roy; Obed John; Nolita Dolcy Saldanha; Ashish R. Bavdekar; Raj Kumar; Shyam Prakash
Purpose: The PRAYAS Individual Patient Data Meta-analysis (IPD-MA) database aims to estimate the prevalence of anemia among children under 18 years, non-pregnant and non-lactating (NPNL) women, and pregnant women (by trimester), with further stratification by age group, year, and region of India. Beyond prevalence, it seeks to address the etiological contribution of iron and other erythropoietic micronutrient deficiencies and to evaluate the effectiveness of anemia prevention and treatment interventions, including factors associated with non-response. This will directly support India’s “test–treat–track” approach under the Anemia Mukt Bharat program. Participants: Children (0–18 years), pregnant women, and NPNL women in India. Findings to date: The database currently includes 88 datasets (1994–2023), with 319,721 participants for prevalence analysis—children (19,762), NPNL women (17,883), and pregnant women (282,076). Intervention studies comprise 59,292 participants—children (13,435), NPNL women (11,594), and pregnant women (34,263). Over half the datasets (55.7%, 49/88) are randomized controlled trials, while 35.2% (31/88) are observational. Geographically, 43.2% (38/88) are from northern India, 22.7% (20/88) from the west, and 18.2% (16/88) from the south. Most studies (67%, 59/88) are community-based. Median ages were 26 years (IQR 23–32) for NPNL and 23 years (IQR 21–25) for pregnant women, while children’s data covered 6 months to 18 years. Mean gestational age at enrollment in pregnancy was 10.24 weeks (SD 17.65). Of the total sample, 10.8% had complete blood count data, 9% ferritin, and 4.5% vitamin B12. Among interventions, pregnant women received intravenous iron sucrose, ferric carboxymaltose, iron isomaltoside, combined IV iron with vitamin B12/folic acid/niacinamide, integrated packages, and low-dose calcium supplementation. NPNL women were often part of trials comparing 60 mg daily ferrous sulfate with 120 mg on alternate days. Children’s interventions mainly included ferrous sulfate, food supplementation, and select Ayush-based approaches. Future plans: PRAYAS will generate robust, policy-relevant evidence to refine anemia prevention and treatment strategies. Findings will directly inform the Anemia Mukt Bharat program, supporting targeted, evidence-driven interventions to reduce anemia and associated health burdens across children, women, and pregnant populations in India. Clinical Trial Registration: OSF—https://doi.org/10.17605/OSF.IO/6YRXF. © © 2025 Pandey, Sinha, Rawat, Chowdhury, Goudar, Nagpal, Desai, Laxmaiah, Basany, Joshi, Yajnik, Mukherjee, Dwarkanath, Bansal, Jacob, Bhatnagar, Shah, Mukherjee, Shukla, Pullakhandam, Dhurde, Apte, Singh, Gupta, Priyanka, Dhingra, Upadhyay, Neogi, Somannavar, Mandal, Desai, Sengupta, Dandge, Wagh, Deshmukh, Kumar, Kurpad, Toteja, John, Sopory, Saha, Babu, Suryavanshi, Palika, Patel, Nimkar, Dwivedi, Kapil, Raja, Dutta, Taneja, Gautam, Kavi, Rawat, Dave, Raman, Haggerty, Lalwani, Phadke, Turuk, Thomas, Bhatia, Beck, Kaur, Shukla, Deepa, Locks, Agarwal, Mamidi, Sachdev, Talukdar, Das, Bhandari, Singh, Yogeshkumar, Yadav, Reddy, Gupte, Ladkat, Gonmei, Rathore, Sharma, Pandya, Ana, Hibberd, Lubree, Dudekula, Lal, Khan, Verma, Charantimath, Meshram, Randhir, Deshmukh, Roy, John, Saldanha, Bavdekar, Kumar, Prakash, Fawzi and Sazawal.