Browsing by Author "V.P. Singh"

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2.45GHz (CW) Microwave irradiation alters circadian organization, spatial memory, DNA structure in the brain cells and blood cell counts of male mice, mus musculus
(Electromagnetics Academy, 2011) Chandra Mohini Chaturvedi; V.P. Singh; P. Singh; P. Basu; M. Singaravel; R.K. Shukla; A. Dhawan; A.K. Pati; R.K. Gangwar; S.P. Singh
Present study examines biological effects of 2.45 GHz microwave radiation in Parkes strain mice. Forty-day-old mice were exposed to CW (continuous wave) microwave radiation (2 h/day for 30 days). Locomotor activity was recorded on running wheel for 12 days prior to microwave exposure (pre-exposure), 7 days during the first week of exposure (short-term exposure) and another 7-day spell during the last week of the 30-day exposure period (long-term exposure). Morris water maze test was performed from 17th to 22nd day of exposure. At the termination of the exposure, blood was processed for hematological parameters, brain for comet assay, epididymis for sperm count and motility and serum for SGOT (serum glutamate oxaloacetate transaminase) and SGPT (serum glutamate pyruvate transaminase). The results show that long-term radiation-exposed group exhibited a positive ψ (phase angle difference) for the onset of activity with reference to lights-off timing and most of the activity occurred within the light fraction of the LD (light: dark) cycle. Microwave radiation caused an increase in erythrocyte and leukocyte counts, a significant DNA strand break in brain cells and the loss of spatial memory in mice. This report for the first time provides experimental evidence that continuous exposure to low intensity microwave radiation may have an adverse effect on the brain function by altering circadian system and rate of DNA damage.
A Bayesian estimation of reliability model using the linex loss function
(1994) M. Pandey; V.P. Singh; C.P.L. Srivastava
In this paper the problem of Bayes estimation of the reliability and the shape parameter p of a finite range failure time model is considered (assuming scale parameter θ is known). Following Zellner [A. Zellner, J. Am. Statist. Assoc. 81, 446-451 (1986)] the asymmetric loss function is used to obtain the Bayes estimators. Efficiencies of the proposed Bayes estimators are obtained with respect to the ordinary Bayes estimators and it was found that the proposed Bayes estimators are better than the ordinary Bayes estimators for quite a wide range of parameters. © 1994.
A cute megakaryoblastic leukaemia: A clinico-haematological profile of five cases
(2004) Jyoti Shukla; Sunita Rai; V.P. Singh
Herein we are presenting the clinical, morphological and cytochemical characteristics of five cases of acute megakaryoblastic leukaemia (AML-M 7) seen by us over a period of five years (Jan 1996 - Dec 2000). Morphological assessment revealed marked polymorphism of blast cells and platelets both in the peripheral blood and bone marrow smears in all cases. Size of the blast cells ranged from very small to very large multinucleated cells, with variable chromatin pattern and number of nucleoli. More differentiated megakaryocytic cells showing cytoplasmic blebs, protrusions and platelet budding with bizarre platelet morphology were characteristic features suggesting the diagnosis. Cytochemical stains like myeloperoxidase, sudan black and PAS were positive in 5 - 15% of blast cell. Coagulation studies revealed a normal coagulation profile, whereas platelet studies showed marked impairment in aggregation of platelets with ADP and adrenalin with a normal PF-3 availability.
A database on occurence patterns of unusual geological incidents in southwest Peninsular India and its implication on future seismic activity
(2005) N.H. Singh; J. Mathai; V.N. Neelakandan; D. Shankar; V.P. Singh
A series of unusual geological incidents have occurred throughout the Kerala State (southwest Peninsular India) during the year 2001 mainly in two active phases i.e. February to March, and June to November 2001. In the beginning during February-March 2001, oscillations and rise in water levels, wavy formations and spouting up of water in the open wells, cracks in the buildings, perceptible ground fissures, shaking of trees/ bushes and enhanced microearthquake activity have occurred. Collapse of shallow open wells, draining of water, lowering of water level, land subsidence, ground fissures etc., and further increased microearthquake activity were the dominant incidents in various parts of the State during June to November 2001. Interestingly, no such incidents had occurred in the past in this region. The frequency of all the above incidents, including microearthquakes activity, reduced drastically to background level beyond November 2001 except a few earthquakes during 2002 and 2003. The incidents are distributed in a vast area irrespective of geology and topography right from coastal stretch to hinterlands in the Western Ghats of India. This chain of incidents was preceded by two moderate size earthquakes of M ∼ 5 on 12 December 2000 and 7 January 2001 which were not capable to trigger such widespread incidents in the region. The temporal patterns of these incidents clearly indicate the p henomenon of rapid ground vibrations at several occasions possibly due to movement of crustal block along certain active fault. This geological process perhaps lead to uplift and tilt of the ground giving rise to several underground water related anomalies and incidents of land deformations. The temporal patterns of individual incident also did not show any clear inter-relationships indicating that all these incidents were caused by a single internal geological process possibly due to converging trend of tectonic stress through the process of redistribution. It is inferred that these incidents constitute a well defined patterns of precursory sequence to a future large seismic activity in the southwest part of Peninsular India. The existence of the present chain of events can be explained by dilatancy diffusion model. Using the spatial distribution of these incidents including microearthquake activity and past significant earthquakes, an east-west trending potential area (10.7 - 10.9° N; 76.0 - 76.8° E) is delineated in the central Kerala region as the preparatory zone for the location of future earthquake. © 2005 Akadémiai Kiadó, Budapest.
A new benzylisoquinoline alkaloid from Argemone mexicana
(2010) Sarita Singh; T.D. Singh; V.P. Singh; V.B. Pandey
A new benzylisoquinoline alkaloid, argemexirine, together with two known protoberberine alkaloids, dl-tetrahydrocoptisine and dihydrocoptisine, have been isolated from the methanolic extract of the whole plant of Argemone mexicana L. The compounds were identified by spectral and chemical evidence. This is the first report of these alkaloids in this plant species.
A new triterpene glycoside from Terminalia arjuna
(1995) B. Singh; V.P. Singh; V.B. Pandey; G. Rucker
A new triterpene diglucoside terminolitin (23-deoxyarjunolitin) has been isolated from the fruits of Terminalia arjuna (Combretaceae) and was identified by IR, 1H- and 13C-NMR spectroscopy.
A NOTE ON THE ANEUPLOIDY IN ARAIOSTEGIA PULCHRA (D. DON) COPEL. AND ASPLENIUM YOSHINAGAEMARINO VAR. PLANICAULE MORTON
(Indian Academy of Sciences, 1989) V.P. Singh; S.K. Roy
[No abstract available]
A plausible model for the present day seismicity and tectonic activity in the Hindukush complex zone
(2005) V.P. Singh; J. Duda; Dayasfeq Shanker
The Hindukush zone is situated on the northern boundary of the Indian Plate along its northwestern flanks. Fifteen years (1974-1988) of seismic data published by United States Coast and Geodetic Surveys (USCGS) and focal mechanism solutions of the subducted lithosphere, reported by different scientists, have been used to model the seismic and tectonic characteristics of the Hindukush complex zone. The data indicate that the zone can be separated into two seismic segments, OP and PQ, with a V-shaped pattern, striking E-W and NE-SW, respectively. The two segments do not represent well-defined subduction zones, as the depth and frequency of events is not uniformly distributed. The E-W striking segment extends from 68.2°E to 70.5°E at about 36.5° N, whereas the northeast-southwest segment extends from 36.5°N, 70.5°E to 38°N, 73°E. The frequency and depth of earthquakes are greatest at 36.5°N, 70.5°E decreasing towards the W and NE. Focal mechanism solutions (thrust and normal faulting) for the Hindukush zone suggest that the directions of stress may be grouped into: 1. Compressive forces acting NE-SW for the east-west striking segment. For the NE-SW striking seismic segment compressive forces are directed towards the NW; 2. Compressive forces are also acting along the strike of the two seismic segments; and 3. The direction of the tensile stress is different in each segment and extends to a depth of up to 221 km. A model is proposed to explain the distribution of earthquake foci in terms of the V-shaped subduction of oceanic lithosphere, with tensile, and compressive stresses in the two seismic belts being due to the upper mantle flow of the Indian Plate and the Tibetan Plateau. The sinking of the mantle in the Hindukush zone is responsible for the stretching of the seismic slab in a vertical direction, giving rise to the present earthquake frequency and focal depth distribution pattern. © 2004 Elsevier Ltd. All rights reserved.
A Review on Phytochemistry and Pharmacology of Medicinal as well as Poisonous Mushrooms
(2018) Diksha Sharma; V.P. Singh; N.K. Singh
Mushrooms have been used as traditional medicine from last few decades. Mushrooms as higher Basidiomycetes contain secondary metabolites in fruit bodies, cultured mycelium, and cultured broth. Medicinal mushrooms possess medicinal properties such as anti-tumor, immunomodulating, antioxidant, cardiovascular, anti-hypercholesterolemic, anti-viral, anti-bacterial, anti-parasitic, antifungal, detoxification, hepatoprotective, and anti-diabetic effects. Phase-I, II, and III clinical trials were studied on various biologically active compounds isolated from medicinal mushrooms and are used adequately to treat various diseases including cancer. The present review focuses on various edible, medicinal and poisonous species of mushrooms belong to genera; Auricularia, Cantherallus, Ganoderma, Pleurotus, Lentinus, Trametes (Coriolus), Tremella and Amanita along with their chemical composition, biologically active compounds isolated and their pharmacological potential. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
A study of seismicity of northeast India and adjoining areas based on statistical analyses
(1994) V.P. Singh; D. Shanker; K. Hamada
Seismicity data from 1912 to 1977 of northeast India for large earthquakes with magnitude M ≥ 6.0 are used to discuss seismicity variation by stationary model of seismicity rates and seismic energy released during three-year intervals. The show that earthquake occurrence follows Poisson distribution. The time series of considered events for different range of magnitude consists of random and non-random. -from Authors
Acquired pure red cell aplasia: is chloroquine a culprit?
(1993) V.P. Singh; S. Sunder; K. Kumar; B. Dube; R.K. Dube
[No abstract available]
Advancing Precision in Penile Length Measurement: Evidence-based Synthesis of Stretched Penile Length INdicator Technique (SPLINT)
(Wolters Kluwer Medknow Publications, 2024) Prabudh Goel; Prativa Choudhury; Komal Kaur Saroya; Vishesh Jain; Anjan Kumar Dhua; Devendra Kumar Yadav; Sachit Anand; Sandeep Agarwala; Kanika Sharma; Vikesh Agrawal; Subhasis Saha; Harpreet Singh; Naveen Sharma; V.P. Singh
Purpose: The purpose of this study was to synthesize evidence and propose a technique for estimation of stretched penile length (SPL) applicable to children. Materials and Methods: This review has been conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. PubMed, Embase, and Scopus databases were queried on penile length (PL) measurement techniques in humans published from 1990 onward. The devices and the techniques used for PL measurement, state of the penis, the habitus of the participants, proximal and distal landmarks for measurement, handling the foreskin and pubic pad of fat, optimal stretching of the penis, and other factors (including the environment) which should be accounted for in the technique were identified from the study cohort (90895 participants across 145 included studies). Results: PL has been represented through flaccid (33.79%), stretched (81.3%), and erect (12.41%) PLs as well as the greatest corporeal length (1.4%). Following devices have been used to measure the PL in the study cohort: rulers [54.68%], calipers [9.7%], measuring tapes [14.5%], coloured measuring strips [2.06%], spatulas/tongue depressors [11.03%], FitKit, syringe [1.4%], cotton swab (and ruler), titan cylinders, slide gauge and ultrasonography [1.37%]. The factors relevant to SPL measurement have been incorporated into the proposed SPL INdicator Technique (SPLINT) which is essentially a holistic extension of the "Conventional PL Measurement"technique. Conclusions: There is a wide range of heterogeneity in the technique for estimation of PL across the study cohort; the underlying factors have been identified along with the respective variables, and the SPLINT for SPL has been described. © 2024 Journal of Indian Association of Pediatric Surgeons.
Aldose reductase and diabetic retinopathy.
(1992) R. Singh; D. Dash; F.J. Ansari; O.P. Maurya; V.P. Singh
Serum aldose reductase activity was estimated spectrophotometrically in 25 normal subjects (Group A), 25 diabetic patients without retinopathy (Group B), and 25 diabetic patients with retinopathy (Group C). Serum aldose reductase levels were higher in diabetic patients with or without retinopathy than in normal subjects. Comparing the serum aldose reductase activity in diabetic patients with and without retinopathy showed the value was higher in the former group; this difference was statistically significant (P < .01). However, aldose reductase activity in proliferative and background retinopathy were equal and therefore not significant.
Amoebic liver abscess in Eastern Uttar Pradesh, India
(1973) V.P. Singh; S.N. Srivastava; P.K. Srivastava; S.K. Vaish; P.N. Somani
A clinical study of 100 cases of amebic liver abscess with special reference to unusual presentation and difficulty in diagnosis is reviewed. Leucocytosis, decreased hemoglobin and raised ESR was observed in 61%, 77% and 90% of cases. Main alterations in liver function test were: low serum albumin, raised alkaline phosphatase and S.G.P.T. in 60.7%, 41.8% and 30% of cases, respectively. Abnormal radiological findings were observed in 84.5% of cases. Their significance has been discussed. Predominant complication was perforation of liver abscess which was seen in 30% of cases. There were 18 deaths in this series. However, incidence of mortality was much higher (60%) in cases with ruptured liver abscess.
Amphotericin B Lipid Complex in the Management of Antimony Unresponsive Indian Visceral Leishmaniasis
(1999) S. Sundar; A.K. Goyal; A.K. Mandal; M.K. Makharia; V.P. Singh; H.W. Murray
Fifty-eight Indian patients with visceral leishmaniasis who did not respond or relapsed after 30 days of consecutive sodium stibogluconate therapy were randomised to treatment with amphotericin B lipid complex (ABLC) using a total dose of 7.5 or 10 mg/kg. Treatment induced a prompt clinical response n all patients with resolution of fever and regression in spleen size. Fever and chills developed during ABLC infusion, but it diminished with successive infusions. Fourteen days after treatment, 26 of 28 (93%) patients in the 7.5 mg/kg group and all 30 (100%) in the 10 mg/kg group had splenic aspirate parasite density scores of 0 and were considered apparent clinical and parasitologic responders. Four and three patients in the 7.5 and 10 mg/kg groups respectively relapsed during six months of followup; thus, overall 22 of 28 (79%) patients treated with 7.5 mg/kg and 27 of 30 (90%) treated with 10 mg/kg were definitive cures. All initial non-responders and relapses were retreated successfully with higher dose of ABLC. These results confirm the efficacy of short-course ABLC therapy for antimony-unresponsive Indian patients with visceral leishmaniasis. Since treatment with a total dose of 7.5 mg/kg did not appear to increase efficacy (79% vs. 84% induced by 5 mg/kg in a prior study), initial treatment with a total dose of 5 mg/kg followed by retreatment of any non-responders represents a potentially less costly approach in patients who fail antimony therapy. Though high cure rates are achieved with ≥ 10 mg/kg total dose of ABLC, treatment using lower doses with retreatment of non-responders or relapses with higher dose can result in considerable savings.
Analyses of ground magnetic anomalies over a part of Vindhyan basin around Damoh and Jabalpur districts, Madhya Pradesh
(1997) V.P. Singh; O.P. Singh; C.L. Singh
Detailed ground magnetic survey over a part of the Vindhyan basin around Damoh and Jabalpur (40 km either sides of Hirapur-Mandala DSS profile) has been carried out. The magnetic field anomaly map is characterised by dense contours in trap covered areas near Jabalpur where as the Vindhyans show sparsely distributed contours with several lows. Spectrum analysis of total ground magnetic field anomalies reveals the average thickness of Vindhyans to be 3.9 km and depth of Conrod to be 15km. The average thickness of Vindhyans is in conformity with the Deep Seismic Sounding results of the region. The thickness of Vindhyan sediments along four profiles ranges from 1.5km to 5km. The maximum thickness of Vindhyan sediments at Jabera has been derived to be 4.8km which is close to the results of Oil and Natural Gas Corporation Ltd., Dehradun.
Analyses of total magnetic anomalies over the northeastern marginal part of Deccan traps and adjoining areas of Central India
(2003) V.P. Singh; O.P. Singh; B.N.P. Agrawal; D. Shanker
Detailed ground magnetic survey has been carried out with the station spacing of 2 to 5 km around Jabalpur-Mandala region. Strong magnetic anomalies are observed in the adjoining areas of Jabalpur-Mandala and adjoining areas of Central India. The anomalies are generally closed and aligned in the E-W to NE-SW direction. Magnetic interpretation predicts an average thickness of 0.6 km for the Deccan traps, besides bringing out shallow and deeper intrusive bodies at 1.5 and 4.5 km, respectively. The average thickness of the trap is in good agreement with DSS (Deep Seismic Sounding) and magnetotelluric results. 2-D modelling along six profiles also suggests a number of sheet and dyke-like structures to be present in the region up to a depth of 4.7 km. It is inferred that many zones of weakness along the E-W to NE-SW direction might have existed prior to the Deccan traps volcanism, along which several intrusives.
Anomalous seismic activity and long-range earthquake prediction in Himachal Pradesh, India
(1995) D. Shanker; H.N. Singh; V.P. Singh
Anomalous seismic activity associated with major earthquakes in the Himalayas have been studied in an area bounded by 30.8° - 33.2°N and 77.4° - 79.4°E using seismicity data from 1959-1991. The seismicity has been found to fluctuate in two characteristic phases from 1959 to 1975, and 1976 to 1991 preceding major earthquakes. It is predicted that a shallow focus significant earthquake in the magnitude range 7-7.4 may occur at the end of 1996 in the area. The probable site of epicenter is estimated to be located in an area bounded by 31.4° - 32°N and 78.3° - 78.8°E falling in the southern half part of the north-south trending preparatory area.
Anomalous seismicity and earthquake forecast in Western Nepal Himalaya and its 1djoining Indian region
(2010) H.N. Singh; H. Paudyal; D. Shanker; A. Panthi; A. Kumar; V.P. Singh
Precursory swarms associated with major earthquakes in the Western Nepal Himalaya and its adjoining region (bounded by 28. 0°-31. 0°N and 79. 5°-82. 2°E) have been studied using seismicity data from 1963 to 2006. The delineation of preparation zones for future seismic disturbances is carried out using the temporal and the spatial distribution of earthquakes, considering the events with cutoff magnitude mb ≥ 4. 3 in four anomalous episodes: normal/background (N); anomalous/swarm (A); precursory gap (G) and main shock sequence (M), respectively. Five cases of anomalous seismicity have been identified, including two cases for which quiescence episodes still continue. Three moderate earthquakes of 1980 (mb 6. 1, Bajhang), 1984 (mb 5. 6, Bajura) and 1999 (mb 6. 6, Chamoli) in Western Nepal and its adjoining Indian region were preceded by well-defined patterns of anomalous seismicity/precursory swarm. Two additional cases of anomalous seismicity patterns were observed: (1) 1999-2006, and (2) 2003-2006. In these two cases no main shock has yet occurred. However, the seismicity from 1999 onwards has fluctuated from low to high to low, as in the precursory sequences for previous earthquakes. The occurrence of the swarm sequence followed by a quiescence phase, which is still continuing, is an indication of a precursory seismicity gap in the region. From the predictive equations developed for the Himalayan frontal arc, it is estimated that an earthquake of M 6. 5 ± 0. 5 may occur at any time up to 2011 in an area bounded by 29. 3°-30. 5°N and 81. 2°-81. 9°E, in the focal depth range 10-30 km. © 2010 Birkhäuser / Springer Basel AG.
Antifungal activity of the mixture of quaternary alkaloids isolated from Argemone mexicana against some phytopathogenic fungi
(2010) Sarita Singh; Amitabh Singh; Jyostana Jaiswal; T.D. Singh; V.P. Singh; V.B. Pandey; Aparna Tiwari; U.P. Singh
The anti-fungal activity of a mixture of quaternary alkaloids of Argemone mexicana was observed at different concentrations (1000, 2000, 3000, 4000 and 5000 μl/ml) against 10 fungi, viz., Ustilago cynodontis, Cercospora cajani, Sphaerotheca sp., Cercospora sp., Alternaria solani, Bipolaris sp., Helminthosporium sp., Curvularia sp., Fusarium udum and Alternaria cajani. Spore germination was inhibited at 2000, 3000, 4000, 5000 μg/ml. Analysis of phenolics by high performance liquid chromatography (HPLC) recorded 11 peaks in the alkaloids but only three could be identified, viz., tannic, caffeic and ferulic acids. The significant efficacy of the alkaloid under in vitro conditions may open the possibility of its use by farmers under field conditions for controlling some crop diseases. © 2010 Taylor & Francis.