Browsing by Author "Vasanthi Ramesh"

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Deceased-donor organ transplantation in india: Current status, challenges, and solutions
(Baskent University, 2020) Vivek Kute; Vasanthi Ramesh; Sunil Shroff; Sandeep Guleria; Jai Prakash
Tamil Nadu, Gujarat, Telangana, Maharashtra, Kerala, Chandigarh, Karnataka, National Capital Territory of Delhi, and Rajasthan are states and union territories having active deceased-donor organ transplant programs in India. Transplant data (2013-2018) have been collected by the National Organ and Tissue Transplant Organization from all states and union territories of India and submitted to the Global Observatory on Donation and Transplantation. From 2013 to 2018, 49 155 transplants were reported in India, including 39 000 living-donor organ recipients and 10 155 deceased-donor organ recipients. These transplants were for kidney (living donor = 32 584, deceased donor = 5748), liver (living donor = 6416, deceased donor = 2967), heart (deceased donor = 895), lung (deceased donor = 459), pancreas (deceased donor = 78), and small bowel (deceased donor = 8). According to 2018 data, India was the second largest transplanting country in the world in terms of the absolute number of transplants. Here, we discuss the status, progress, challenges, and solutions for deceased-donor organ transplantation. The plan to increase rates of organ donation in India include the following points: teamwork and focus by intensive care unit doctors; public education on organ donation using social media; professional education and family donation conversation programs for brain death declaration and donor management; organ procurement organizations; international collaboration and regular meetings and updates for organizations working in the field of organ transplantation; grief counseling and reporting of potential donation for families of recently deceased people; nonfinancial incentivization to families of potential organ donors; expert committees and standard operating protocols for use of marginal donor organs, donation after circulatory death programs, and machine perfusion; maintenance of transparency and ethics in organ donation, allocation, and transplantation as directed by governmental, nongovernmental, and intergovernmental entities; and regular audit of progress and registry data. © 2020, Baskent University. All rights reserved.
Notto covid-19 vaccine guidelines for transplant recipients
(Wolters Kluwer Medknow Publications, 2021) Vivek Kute; Sanjay Agarwal; Jai Prakash; Sandeep Guleria; Sunil Shroff; Ashish Sharma; Prem Varma; Narayan Prasad; Manisha Sahay; Subhash Gupta; S. Sudhindran; Kewal Krishan; Vasanthi Ramesh; Sunil Kumar
In December 2019, novel coronavirus (SARS-CoV-2) infection started in Wuhan and resulted in a pandemic within a few weeks' time. Organ transplant recipients being at a risk for more severe COVID-19 if they get SARS CoV-2 viral infection, COVID-19 vaccine has a significant role in these patients. The vaccine is a safer way to help build protection and would either prevent COVID-19 infection or at least diminish the severity of the disease. It would also reduce the risk of the continuing transmission and enhance herd immunity. Immuno-compromised patients should not receive live vaccines as they can cause vaccine-related disease and hence the guidelines suggest that all transplant recipients should receive age-appropriate 'inactivated vaccine' as recommended for general population. Though trials have not been undertaken on transplant recipients, efficacy and safety of COVID-19 vaccine have been scientifically documented for few vaccines among the general population. © 2021 Indian Journal of Nephrology.
NOTTO COVID-19 vaccine guidelines for transplant recipients
(Wolters Kluwer Medknow Publications, 2021) Vivek Kute; Sanjay K. Agarwal; Jai Prakash; Sandeep Guleria; Sunil Shroff; Ashish Sharma; Prem Varma; Narayan Prasad; Manisha Sahay; Subhash Gupta; S. Sudhindran; Kewal Krishan; Vasanthi Ramesh; Sunil Kumar
In December 2019 Novel corona virus (SARS-CoV-2) infection started in Wuhan and resulted in a pandemic within few weeks' time. Organ transplant recipients being at a risk for more severe COVID-19 if they get SARS CoV-2 viral infection, COVID 19 Vaccine has a significant role in these patients. The vaccine is a safer way to help build protection and would either prevent COVID -19 infection or atleast diminish the severity of the disease. It would also reduce the risk of the continuing transmission and enhance herd immunity. Immuno compromised patients should not receive live vaccines as they can cause vaccine related disease and hence the guidelines suggest that all transplant recipients should receive age appropriate 'inactivated vaccine' as recommended for general population. Though trials have not been undertaken on transplant recipients, efficacy and safety of COVID-19 vaccine have been scientifically documented for few vaccines among the general population. © 2021 Indian Journal of Transplantation | Published by Wolters Kluwer - Medknow.
NOTTO transplant specific guidelines with reference to COVID-19
(Wolters Kluwer Medknow Publications, 2020) Vivek Kute; Sandeep Guleria; Jai Prakash; Sunil Shroff; Narayan Prasad; Sanjay Agarwal; Santosh Varughese; Subhash Gupta; A. K Gokhale; Manisha Sahay; Ashish Sharma; Prem Varma; Anil Bhalla; Harsh Vardhan; Manish Balwani; Shruti Dave; Dhamendra Bhadauria; Manish Rathi; Dhananjay Agarwal; Pankaj Shah; Vasanthi Ramesh; Rajiv Garg
[No abstract available]
Update on Coronavirus 2019 Vaccine Guidelines for Transplant Recipients
(Elsevier Inc., 2022) Vivek Kute; Hari Shankar Meshram; Ashish Sharma; Arpita Ray Chaudhury; S. Sudhindran; AllaGopala Krishna Gokhale; Milind Hote; Randeep Guleria; Devinder Singh Rana; Jai Prakash; Vasanthi Ramesh
The coronavirus disease 2019 (COVID-19) vaccine and its utility in solid organ transplantation need to be timely revised and updated. These guidelines have been formalized by the experts—the apex technical committee members of the National Organ and Tissue Transplant Organization and the heads of transplant societies—for the guidance of transplant communities. We recommend that all personnel involved in organ transplantation should be vaccinated as early as possible and continue COVID-19–appropriate behavior despite a full course of vaccination. For specific guidelines of recipients, we suggest completing the full schedule before transplantation whenever the clinical condition permits. We also suggest a single dose, rather than proceeding unvaccinated for transplant, in case a complete course is not feasible. If vaccination is planned before surgery, we recommend a gap of at least 2 weeks between the last dose of vaccine and surgery. For those not vaccinated before transplant, we suggest waiting 4 to 12 weeks after transplant. For the potential living donors, we recommend the complete vaccination schedule before transplant. However, if this is not feasible, we suggest receiving at least a single dose of the vaccine 2 weeks before donation. We suggest that suitable transplant patients and those on the waiting list should accept a third dose of the vaccine when one is offered to them. We recommend that organs from a deceased donor with suspected/proven vaccine-induced thrombotic thrombocytopenia should be avoided and are justified only in cases of emergency situations with informed consent and counseling. © 2021 Elsevier Inc.