Browsing by Author "Veer Singh"

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Advancements in Modeling-Based Therapeutics and Technology for Chronic Diseases
(Elsevier, 2025) Sachchida Nand Rai; Santosh Kumar Singh; Veer Singh
Advancements in Modeling-Based Therapeutics and Technology for Chronic Diseases delves into the crucial role of animal and cellular models in comprehending the intricate mechanisms of chronic diseases. The book emphasizes the importance of these models in predicting disease progression, testing new therapeutic approaches, and understanding how environmental and genetic factors interplay in the development of long-term health conditions. With a multidisciplinary approach, it bridges the gap between experimental research and clinical applications, offering insights into not only disease management but also the future of personalized medicine. The book also sheds light on emerging technologies, including bioinformatics tools and in silico modeling, which further enhance our ability to tackle chronic diseases. It explores how these advancements are transforming research methodologies and providing novel solutions for diagnosis and treatment. Additionally, it highlights collaborative strategies between researchers, clinicians, and technologists, stressing the importance of integrated efforts in addressing global health challenges effectively. © 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
Arsenic exposure to mouse visceral leishmaniasis model through their drinking water linked to the disease exacerbation via modulation in host protective immunity: a preclinical study
(Nature Research, 2023) Ghufran Ahmed; Fauzia Jamal; Ritesh K. Tiwari; Veer Singh; Sachchida Nand Rai; Sanjay K. Chaturvedi; Krishna Pandey; Santosh K. Singh; Ashish Kumar; Shyam Narayan; Emanuel Vamanu
A large body of evidence has shown a direct link between arsenic exposure and drug resistance to Leishmania parasites against antimonial preparations in visceral leishmaniasis (VL) hyper-endemic regions, especially in India and its sub-continent. However, the implicated roles of arsenic on the VL host, pathophysiological changes, and immune function have not yet been clarified, particularly at the reported concentration of arsenic in the VL hyper-endemic area of Bihar, India. Herein, we exposed the mouse VL model to arsenic (0.5 mg/L to 2 mg/L) through their drinking water and analyzed its effect on T cells proliferation, Th1/Th2-mediators, MAPK signaling cascade, and parasite load in preclinical models. Coherently, the parasite count in Giemsa stained spleen imprint has been investigated and found significant positive associations with levels of arsenic exposure. The liver and kidney function tests (AST, ALT, ALP, BUN, Creatinine, Urea, etc.) are apparent to hepatonephric toxicity in arsenic exposed VL mice compared to unexposed. This observation appears to be consistent with the up-regulated expression of immune regulatory Th2 mediators (IL-4, IL-10, TGF-β) and down-regulated expression of Th1 mediators (IL-12, IFN-γ, TNF-α) with a suppressed leishmanicidal function of macrophage (ROS, NO, iNOS). We also established that arsenic exposure modulated the host ERK-1/2 and p38 MAPK signaling cascade, limited T lymphocyte proliferation, and a lower IgG2a/IgG1 ratio to favor the Leishmania parasite survival inside the host. This study suggests that the contorted Th1-subtype and exacerbated Th2-subtype immune responses are involved in the increased susceptibility and pathogenesis of Leishmania parasite among subjects/individuals regularly exposed to arsenic. © 2023, The Author(s).
Bacterial diversity in rice field soil and sludge soil samples: a comparative metagenomics-based study
(Institute of Physics, 2024) Nidhi Singh; Veer Singh; Vishal Mishra; Vivek K Chaturvedi; Emanuel Vamanu; Mohan P. Singh
Soil contains several organic, and inorganic substances and a large number of bacterial diversity. This bacterial diversity is also involved in biomass degradation and plant growth promotion. Metagenomic sequencing was used to analyze bacterial diversity in the rice field soil and sludge samples. Amplicon sequencing of the V3-V4 region of the 16S rRNA gene revealed that representative sequences clustered were 0.4 million in both rice and sludge samples. The Venn diagram demonstrates the overall identified OTUs was 359 Operational Taxonomic Units (OTUs). OTUs were classified into more than 30 phyla, 50 classes, and 90 genera. The metagenomic analysis revealed that 82 and 85 taxa are exclusively unique to the bacterial communities of the rice and sludge soils, respectively. The metagenomic study also revealed that Proteobacteria, Bacteroidetes, Chloroflexi, Acidobacteria and other unknown bacteria were reported in 16S rRNA Illumina MiSeq in the sludge and rice soil samples. The most abundant groups in rice field soil were Proteobacteria, Chloroflexi, Acidobacteria, Actinobacteria, and Bacteroidetes which increase the soil nutrient and influence the growth of the plants. Bacteroidetes are the most dominant group in sludge soil than rice field soil. This comparative analysis provides insights into the ecological roles and adaptive strategies of soil bacteria in different environmental contexts, offering valuable information for sustainable soil management and bioremediation practices. © 2024 The Author(s). Published by IOP Publishing Ltd.
Chitosan functionalized recyclable and eco-friendly nanoadsorbent for Pb(II) adsorption from water
(Taylor and Francis Ltd., 2024) Veer Singh; Nidhi Singh; Sachchida Nand Rai; Vivek K. Chaturvedi; Santosh K. Singh; Ashish Kumar; Emanuel Vamanu; Vishal Mishra
In the present study, MnO2 nanoparticles were synthesized using Citrus limetta peels extract and functionalized by chitosan polymer. Surface morphology analysis of chitosan functionalized MnO2 nanoparticles was carried out using a scanning electron microscope (SEM) and transmission electron microscope (TEM), which revealed that the synthesized nanoparticles were spherical, with a size range of 14–24 nm. Energy dispersive X-ray analysis and elemental mapping were used to observe Mn, O, C, H, and N. Fourier-transform infrared spectroscopy confirmed the presence of hydroxyl, carboxyl, and amino groups on the surface of the nanoparticles. The kinetics and isotherms were compared and it was found that the pseudo-second-order and Langmuir isotherm were the best fit, with R2 values of 0.99. The thermodynamic study demonstrated that the adsorption was endothermic and spontaneous. These findings indicate that chitosan functionalized nanoparticles have a better Pb(II) removal efficiency (94.40%), making them an eco-friendly and cost-effective alternative for wastewater treatment. Highlights Chitosan functionalized nanoadsorbent was synthesized through green route. Sorption mechanism explored through isotherm, kinetics, and thermodynamic models. Synthesized adsorbent showed high Pb(II) removal capacity. © 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Computational Approaches to Designing Antiviral Drugs against COVID-19: A Comprehensive Review
(Bentham Science Publishers, 2023) Mohan P. Singh; Nidhi Singh; Divya Mishra; Saba Ehsan; Vivek K. Chaturvedi; Anupriya Chaudhary; Veer Singh; Emanuel Vamanu
The global impact of the COVID-19 pandemic caused by SARS-CoV-2 necessitates innovative strategies for the rapid development of effective treatments. Computational methodologies, such as molecular modelling, molecular dynamics simulations, and artificial intelligence, have emerged as indispensable tools in the drug discovery process. This review aimed to provide a comprehensive overview of these computational approaches and their application in the design of antiviral agents for COVID-19. Starting with an examination of ligand-based and structure-based drug discovery, the review has delved into the intricate ways through which molecular modelling can accelerate the identification of potential therapies. Additionally, the investigation extends to phytochemicals sourced from nature, which have shown promise as potential antiviral agents. Noteworthy compounds, including gallic acid, naringin, hesperidin, Tinospora cordifolia, curcumin, nimbin, azadironic acid, nimbionone, nimbionol, and nimocinol, have exhibited high affinity for COVID-19 Mpro and favourable binding energy profiles compared to current drugs. Although these compounds hold potential, their further validation through in vitro and in vivo experimentation is imperative. Throughout this exploration, the review has emphasized the pivotal role of computational biologists, bioinformaticians, and biotechnologists in driving rapid advancements in clinical research and therapeutic development. By combining state-of-the-art computational techniques with insights from structural and molecular biology, the search for potent antiviral agents has been accelerated. The collaboration between these disciplines holds immense promise in addressing the transmissibility and virulence of SARS-CoV-2. © 2023 Bentham Science Publishers.
Development of Effective Antileishmanial Herbal Drug from Withania Somnifera and Tinospora Cordifolia Extracts
(Bentham Science Publishers, 2025) Ritesh Kumar Tiwari; A. Kumar; Veer Singh; Sachchida Nand Rai; Santosh Kumar Singh; Ghufran Ahmed; Emanuel Vamanu; Meenakshi Singh
Background: Visceral leishmaniasis is a vector-borne immune-related disease that manifests mainly by lowering of immune protective T-helper-1 cells and onset of disease-promoting T-helper-2 cells therefore the treatment of visceral leishmaniasis depends on boosting the immune status of the host. Methods: In this study, two traditional medicinal plants Withania somnifera and Tinospora cordifolia were selected, and their whole plant extracts were used for treating visceral leishmaniasis-infected BALB/c mice. Observing the case of immune suppression and balance of Th-1/Th-2 dichotomy during visceral leishmaniasis in mind, the efficacy of these combined herbal drugs against visceral leishmaniasis infected mice was evaluated by monitoring the restoration of T-helper-1 type protective immune response. Results: To evaluate the effectiveness of these drugs against visceral leishmaniasis, reactive nitrogen species and reactive oxygen species were measured. Biochemical parameters were also performed from blood serum samples during this study, and normalized results were obtained in visceral leishmaniasis-infected mice treated with Withania somnifera and Tinospora cordifolia subgroup. The Amphotericin B treated subgroup was considered as standard positive control during the experiment. Conclusion: A combination of herbal drugs resulted in a successful clearance of Leishmania parasite as well as increased immune protective T-helper-1 cells, suggesting these drugs as efficient antileishmanial agents. © 2025 Bentham Science Publishers
Heavy Metal Contamination in the Aquatic Ecosystem: Toxicity and Its Remediation Using Eco-Friendly Approaches
(MDPI, 2023) Veer Singh; Nidhi Singh; Sachchida Nand Rai; Ashish Kumar; Anurag Kumar Singh; Mohan P. Singh; Ansuman Sahoo; Shashank Shekhar; Emanuel Vamanu; Vishal Mishra
Urbanization and industrialization are responsible for environmental contamination in the air, water, and soil. These activities also generate large amounts of heavy metal ions in the environment, and these contaminants cause various types of health issues in humans and other animals. Hexavalent chromium, lead, and cadmium are toxic heavy metal ions that come into the environment through several industrial processes, such as tanning, electroplating, coal mining, agricultural activities, the steel industry, and chrome plating. Several physical and chemical methods are generally used for the heavy metal decontamination of wastewater. These methods have some disadvantages, including the generation of secondary toxic sludge and high operational costs. Hence, there is a need to develop a cost-effective and eco-friendly method for the removal of heavy metal ions from polluted areas. Biological methods are generally considered eco-friendly and cost-effective. This review focuses on heavy metal contamination, its toxicity, and eco-friendly approaches for the removal of heavy metals from contaminated sites. © 2023 by the authors.
Heavy Metal Contamination in the Environment: Health Impacts and Potential Remediation Approaches
(CRC Press, 2024) Veer Singh; Ashish Kumar; Vishal Mishra; Sachchida Nand Rai
This reference book explores the multifaceted problem of heavy metal contamination in the environment. Through its in-depth analysis, the book provides a thorough overview of the sources and pathways of heavy metals, their persistence in ecosystems, and the resulting health impacts on individuals and ecosystems. The chapters explore the diverse sources of contamination, including industrial activities, mining, agriculture, and urbanization, while examining the types of heavy metals found in the environment and their toxicological properties. The book further reviews the profound health effects associated with heavy metal exposure, such as neurological disorders, developmental abnormalities, carcinogenicity, and organ damage. Furthermore, the book provides insights into risk assessment methodologies, regulatory frameworks, and guidelines aimed at controlling and minimizing heavy metal exposure. It highlights the challenges and gaps in current regulations, identifies potential areas for improvement, and presents analytical techniques for heavy metal analysis and removal. This book is an important source for researchers and professionals working in the fields of environmental science, toxicology, and public health. © 2025 selection and editorial matter Veer Singh, Ashish Kumar, Vishal Mishra and Sachchida Nand Rai; individual chapters, the contributors.
Hexavalent-Chromium-Induced Oxidative Stress and the Protective Role of Antioxidants against Cellular Toxicity
(MDPI, 2022) Veer Singh; Nidhi Singh; Manisha Verma; Rashmi Kamal; Ritesh Tiwari; Mahesh Sanjay Chivate; Sachchida Nand Rai; Ashish Kumar; Anupama Singh; Mohan P. Singh; Emanuel Vamanu; Vishal Mishra
Hexavalent chromium is a highly soluble environmental contaminant. It is a widespread anthropogenic chromium species that is 100 times more toxic than trivalent chromium. Leather, chrome plating, coal mining and paint industries are the major sources of hexavalent chromium in water. Hexavalent chromium is widely recognised as a carcinogen and mutagen in humans and other animals. It is also responsible for multiorgan damage, such as kidney damage, liver failure, heart failure, skin disease and lung dysfunction. The fate of the toxicity of hexavalent chromium depends on its oxidation state. The reduction of Cr (VI) to Cr (III) is responsible for the generation of reactive oxygen species (ROS) and chromium intermediate species, such as Cr (V) and Cr (IV). Reactive oxygen species (ROS) are responsible for oxidative tissue damage and the disruption of cell organelles, such as mitochondria, DNA, RNA and protein molecules. Cr (VI)-induced oxidative stress can be neutralised by the antioxidant system in human and animal cells. In this review, the authors summarise the Cr (VI) source, toxicity and antioxidant defence mechanism against Cr (VI)-induced reactive oxygen species (ROS). © 2022 by the authors.
In Vitro Cytotoxic Assessment of Functionalized Multi-walled Carbon Nanotubes Against Cervical Cancer
(Springer, 2023) Vivek K. Chaturvedi; Abhay Dev Tripathi; Tarun Minocha; Veer Singh; Mohan P. Singh; Dawesh P. Yadav
Cervical cancer is the most prevalent reproductive malignancy that affects the female reproductive system. A myriad of anti-cancer compounds has been used for its treatment, but the increasing mortality rates are still devastating. Currently, organic metal complexes are gaining popularity due to their anti-cancer attributes. Therefore, the current work was designed to assess the therapeutic efficacy of non-functionalized multi-walled carbon nanotubes (N-MWCNT) and functionalized MWCNTs (F-MWCNT) against cervical cancer. Initially, N-MWCNTs and F-MWCNTs were structurally characterized by various parameters, including FTIR, XRD, TEM, SEM, AFM, and EDAX. Our comparative study revealed that F-MWCNTs have a larger surface area and the presence of OH and COOH as functional groups, which are uniformly distributed in the tubular and crystalline structure. Furthermore, the MTT assay revealed IC50 values of 47.70 µg/ml and 61.94 µg/ml of N- MWCNTs and F-MWCNT, respectively; in that relation, our immunoblot results show upregulation of BAX and downregulation of BCL-2 in either of the cases, with N-MWCNT having 2.92 and 0.45 folds in comparison to 2.68 and 0.41 folds of F-MWCNT. Our results revealed that both materials inhibited cell proliferation and induced apoptosis in a dose-dependent manner. Still, the effect of N-MWCNTs was more prominent as compared to F-MWCNTs. The overall conclusions of this study indicated that doses of F-MWCNTs could be explored for the safe drug delivery vehicle used as an effective biocompatible nanoformulation agent and this will open a new door for cervical cancer treatment. © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Metagenomic Analysis of Garden Soil-Derived Microbial Consortia and Unveiling Their Metabolic Potential in Mitigating Toxic Hexavalent Chromium
(MDPI, 2022) Nidhi Singh; Veer Singh; Sachchida Nand Rai; Emanuel Vamanu; Mohan P. Singh
Soil microbial communities connect to the functional environment and play an important role in the biogeochemical cycle and waste degradation. The current study evaluated the distribution of the core microbial population of garden soil in the Varanasi region of Uttar Pradesh, India and their metabolic potential for mitigating toxic hexavalent chromium from wastewater. Metagenomes contain 0.2 million reads and 56.5% GC content. The metagenomic analysis provided insight into the relative abundance of soil microbial communities and revealed the domination of around 200 bacterial species belonging to different phyla and four archaeal phyla. The top 10 abundant genera in garden soil were Gemmata, Planctomyces, Steroidobacter, Pirellula, Pedomicrobium, Rhodoplanes, Nitrospira Mycobacterium, Pseudonocardia, and Acinetobacter. In this study, Gemmata was dominating bacterial genera. Euryarchaeota, Parvarchaeota, and Crenarchaeota archaeal species were present with low abundance in soil samples. X-ray photoelectric spectroscopy (XPS) analysis indicates the presence of carbon, nitrogen–oxygen, calcium, phosphorous, and silica in the soil. Soil-derived bacterial consortia showed high hexavalent chromium [Cr (VI)] removal efficiency (99.37%). The bacterial consortia isolated from garden soil had an important role in the hexavalent chromium bioremediation, and thus, this study could be beneficial for the design of a heavy-metal treatment system. © 2022 by the authors.
Natural Polymeric Nanoparticles for Brain Targeting
(CRC Press, 2024) Gaurav K. Pandit; Ritesh K. Tiwari; Ashish Kumar; Veer Singh; Gufran Ahmed; Shazia Kazmi; Shaliha Irfan; Vishal Mishra; Anurag Kumar Singh; Snigdha Singh; Meenakshi Singh
Natural polymeric nanoparticles (NPNs) have arisen as promising transporters for brain focusing because of their biocompatibility and biodegradability (Singh et al., 2021a). These NPNs are produced using natural polymers like proteins, polysaccharides, and lipids, which proposition benefits over manufactured polymers concerning security and decreased immunogenicity. NPNs have the capacity to encapsulate various therapeutic agents, such as small molecules, peptides, and genes, and transport them to the brain in a targeted manner. Drug delivery to the brain is particularly challenging due to the presence of the blood-brain barrier (BBB), which restricts the entry of many drugs into the central nervous system (CNS). Brain. Nevertheless, NPNs have been shown to defeat the BBB through different components, including dynamic focusing on, detached focusing on, and transcytosis. Dynamic focusing on includes the alteration of the NPN surface with ligands that explicitly tie to receptors on the BBB, prompting endocytosis and transport across the BBB. Latent focusing on exploits the improved porousness and maintenance impact, which brings about the amassing of NPNs in the cerebrum because of the sluggish leeway of bigger particles from the BBB. Transcytosis is a cycle where NPNs are taken up by cerebrum microvascular endothelial cells and afterward shipped across the BBB into the CNS. NPNs have been examined for different brain neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, glioma, and various sclerosis. For instance, NPNs typifying little atom drugs, such as donepezil, have been shown to work on neurodegenerative disorders in Alzheimer’s disease models. Likewise, NPNs exemplifying restorative qualities have been utilized to convey quality treatment to the cerebrum for the treatment of Parkinson’s disease. NPNs have likewise been examined as vehicles for imaging specialists, for example, attractive reverberation imaging (X-ray) contrast specialists, and for the conveyance of radiotherapy to brain tumors. NPNs offer a promising methodology for brain targating because of their biocompatibility and biodegradability, and their capacity to embody differenttherupatic agents. The capacity of NPNs to penetrate in to the BBB and convey medications to the brain in a designated way has been shown in differentbrain disorders. brain However, additional research is required to enhance the design and formulation of NPNs for specific brain disorders and to fully realize their potential for drug delivery to the brain. © 2024 selection and editorial matter, Anurag Kumar Singh, Vivek K. Chaturvedi, and Jay Singh; individual chapters, the contributors.
Preface
(Elsevier, 2025) Sachchida Nand Rai; Santosh Kumar Singh; Veer Singh
[No abstract available]
Source of Cr(VI) in the aquatic ecosystem, its genotoxic effects and microbial removal from contaminated water
(Taylor and Francis Ltd., 2023) Veer Singh; Kumar Abhishek; Sachchida Nand Rai; Santosh K. Singh; Emanuel Vamanu; Ashish Kumar
Cr(VI) compounds have important industrial applications and are used in various sectors like tanning, chrome plating, anti-corrosion agents and wood preservation. The Cr(VI) contamination in the wastewater is generally due to several natural and anthropogenic sources. Anthropogenic activities like several industrial operations play a major role in the Cr(VI) contamination in the aquatic ecosystem. Cr(VI) well-known toxic metal ion and its exposure in humans causes several health issues. Cr(VI) enters the cells and gradually reduces into a lower oxidation state and generates oxidative stress in the cell which damages cell organelles. The Cr(VI) mediated genotoxicity has been described as damaging the DNA base pairing, sugar-phosphate backbone, histone modification and chromosomal damage. Water and wastewater must be treated to remove Cr(VI) due to its high toxicity. There are several, physiochemical methods used for Cr(VI) remediation but these approaches are expensive and produce hazardous sludge during the treatment process. Therefore, a suitable environmentally friendly and effective Cr(VI) removal approach is urgently needed. Microbial removal of Cr(VI) is considered an eco-friendly and cost-effective process. In this, the authors focused on sources, genotoxicity and microbial remediation approaches of Cr(VI). © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Toxic heavy metal ions contamination in water and their sustainable reduction by eco-friendly methods: isotherms, thermodynamics and kinetics study
(Nature Research, 2024) Veer Singh; Ghufran Ahmed; Sonali Vedika; Pinki Kumar; Sanjay K. Chaturvedi; Sachchida Nand Rai; Emanuel Vamanu; Ashish Kumar
Heavy metal ions can be introduced into the water through several point and non-point sources including leather industry, coal mining, agriculture activity and domestic waste. Regrettably, these toxic heavy metals may pose a threat to both humans and animals, particularly when they infiltrate water and soil. Heavy metal poisoning can lead to many health complications, such as liver and renal dysfunction, dermatological difficulties, and potentially even malignancies. To mitigate the risk of heavy metal ion exposure to humans and animals, it is imperative to extract them from places that have been polluted. Several conventional methods such as ion exchange, reverse osmosis, ultrafiltration, membrane filtration and chemical precipitation have been used for the removal of heavy metal ions. However, these methods have high operation costs and generate secondary pollutants during water treatment. Biosorption is an alternative approach to eliminating heavy metals from water that involves employing eco-friendly and cost-effective biomass. This review is focused on the heavy metal ions contamination in the water, biosorption methods for heavy metal removal and mathematical modeling to explain the behaviour of heavy metal adsorption. This review can be helpful to the researchers to design wastewater treatment plants for sustainable wastewater treatment. © The Author(s) 2024.
Two-stage cultivation of microalga for sustainable biofuel production
(Taylor and Francis Ltd., 2025) Gyanendra Tripathi; Priyanka Dubey; Khwaja Osama; Suahil Ahmad; Irum; Veer Singh; Alvina Farooqui; Emanuel Vamanu; Sachchida Nand Rai; Vishal Mishra
This two-stage system comprises an airlift-driven low-tubular photobioreactor for continuous microalgal (strain Scenedesmus sp. GTAF_01 IU) growth and an open raceway pond for stress-induced coordinated lipid accumulation due to nutrient deprivation. A support vector regression (SVR) model was used to develop the predictive model to predict the cell biomass on a dry basis at different culture conditions. A maximum biomass (dry weight) of 1.65 g was achieved at a light intensity of 27 µmol m−2 s−1 photosynthetic photon flux density (PPFD), mixing speed of 150 revolutions per minute, pH 7, and light and dark cycle of 12 h each. The model accuracy was verified by performing experiments at the optimal conditions that resulted in an enhanced biomass (dry weight) of 1.69 g, which was close to the expected one. The results also showed a significant increase in carbohydrate, protein, and lipid content of 27%, 64%, and 47%, respectively. This study provides novel insights into a two-phase cultivation system combining a closed photobioreactor and an open raceway pond for Scenedesmus sp. GTAF_01 IU, resulting in enhanced biomass growth and lipid content. This enhancement supports its potential for sustainable biofuel production within a circular economy framework. © 2025 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
WNT-β Catenin Signaling as a Potential Therapeutic Target for Neurodegenerative Diseases: Current Status and Future Perspective
(Multidisciplinary Digital Publishing Institute (MDPI), 2023) Kakarla Ramakrishna; Lakshmi Vineela Nalla; Dumala Naresh; Kojja Venkateswarlu; Matte Kasi Viswanadh; Buchi N. Nalluri; Guntupalli Chakravarthy; Sajusha Duguluri; Payal Singh; Sachchida Nand Rai; Ashish Kumar; Veer Singh; Santosh Kumar Singh
Wnt/β-catenin (WβC) signaling pathway is an important signaling pathway for the maintenance of cellular homeostasis from the embryonic developmental stages to adulthood. The canonical pathway of WβC signaling is essential for neurogenesis, cell proliferation, and neurogenesis, whereas the noncanonical pathway (WNT/Ca2+ and WNT/PCP) is responsible for cell polarity, calcium maintenance, and cell migration. Abnormal regulation of WβC signaling is involved in the pathogenesis of several neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and spinal muscular atrophy (SMA). Hence, the alteration of WβC signaling is considered a potential therapeutic target for the treatment of neurodegenerative disease. In the present review, we have used the bibliographical information from PubMed, Google Scholar, and Scopus to address the current prospects of WβC signaling role in the abovementioned neurodegenerative diseases. © 2023 by the authors.