Browsing by Author "Venkatadri S. Sunder"

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    Identifying the mechanisms of α-synuclein-mediated cytotoxicity in Parkinson's disease: New insights from a bioinformatics-based approach
    (Future Medicine Ltd., 2020) Sankha S. Chakrabarti; Venkatadri S. Sunder; Upinder Kaur; Sapna Bala; Priyanka Sharma; Manjari Kiran; Ravindra K. Rawal; Sasanka Chakrabarti
    Aim: A large body of evidence has implicated the cytotoxicity of α-synuclein in Parkinson's disease (PD). We planned to use a bioinformatics-based approach to gain further insight into this process. Materials & methods: Using STRING version 10, we identified interacting proteins of α-synuclein. Using α-synuclein and one of these interactors involved in apoptosis as query proteins, we identified other linked proteins. We further analyzed the interactions between some of these proteins by Protein-Protein Docking using ClusPro. Results: We identified BAX as an interacting protein of α-synuclein. Interactions of α-synuclein and BAX as well as BAX and BCL2L1 were determined. Conclusion: The interaction of α-synuclein and BAX could play a crucial role in the cell death process of PD where apoptosis and mitochondrial permeability transition-driven necrosis may coexist. © 2020 Sankha Shubhra Chakrabarti.
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