Browsing by Author "Vijay Tripathi"

Now showing 1 - 9 of 9

An insight into the molecular docking interactions of plant secondary metabolites with virulent factors causing common human diseases
(Elsevier B.V., 2022) Ajay Kumar; Sandeep Kumar Singh; Vipin Kumar Singh; Chandra Kant; Amit Kishore Singh; Vijay Tripathi; Kalpna Singh; Vijay Kumar Sharma; Joginder Singh
Plant natural products or secondary metabolites have gained significant attention globally because of discoveries of semi-synthetic drugs novel bioactive compounds. Currently, a large part of global population relies on natural products to cure ailments and even chronic diseases and to enhance their immune system. Interestingly, the commonly used drugs for the treatment of some common human diseases like cancer, ulcer, tuberculosis, asthma, etc., have been reported to be of plant origin and recognized to elicit beneficial effects in virulent factors of diseases in vivo and in vitro. The herbal drugs are economical and considered as safe upto certain extent from major side effects. But, still there is need of rapid collection, characterization, taxonomy, certification, and storage for broad, efficient and effective use in drug design or discovery. In this review, we summarized the plants derived secondary metabolites used in treating common human diseases and emphasised the protein-ligand interactions between virulent factors of diseases namely Insulin, p53, Proteasome-associated ATPase, Enterotoxin, Choleragen, IgE with secondary metabolites Aloin, Sesamin, Alliin, Flavanon, Salannin Octyl-β-d-Glucopyranoside of plants respectively, through molecular docking. This study will play a valuable and effective role in drug designing and screening plant-derived metabolites for drug designing. © 2021 SAAB
Application of water quality index (WQI) and statistical techniques to assess water quality for drinking, irrigation, and industrial purposes of the Ghaghara River, India
(Elsevier B.V., 2023) Nirdesh Kumar Ravi; Pawan Kumar Jha; Kriti Varma; Piyush Tripathi; Sandeep Kumar Gautam; Kirpa Ram; Manish Kumar; Vijay Tripathi
Ghaghara river samples were analysed to determine their quality and fitness for household, agriculture, and industrial use. In Ghaghara River, the cations were present in order of Ca2+ > Mg2+ > Na+ > K +, and anions were in order of HCO3– > SO42− > Cl− > NO3– > F−. Gibbs's diagram indicated that carbonate and silicate weathering significantly influence the Ghaghara River ion chemistry. Piper trilinear diagrams indicated that Ca2++ Mg2+ exceeded the Na++ K +, and anions of weak acids dominated over the anions of strong acids, indicating Ca-HCO3 type of water. Based on the WQI values, the water quality class varied from 'unsuitable for drinking' to 'excellent' quality, and the parameter of concern was pH and fluoride ion concentration as they exceeded their permissible limits in the post-monsoon season, thereby negatively affecting the WQI values to unsuitable category. The computed value of the agriculture indices, including the Sodium absorption ratio (SAR), Sodium percentage (Na %), Kelly ratio (KR), Permeability Index (PI) value, Magnesium absorption ratio (MAR), and Potential salinity (PS), indicated that water quality was suitable for agriculture use. The Langelier Saturation Index (LSI) values indicated that 39% of the collected samples were unsuitable due to scale formation problems. Ryznar Stability Index (RSI) values indicated that the water of the Ghaghara River is corrosive and unsuitable for industrial use. © 2023 The Author(s)
Current Scenario and Future Prospects of Endophytic Microbes: Promising Candidates for Abiotic and Biotic Stress Management for Agricultural and Environmental Sustainability
(Springer, 2023) Uttpal Anand; Tarun Pal; Niraj Yadav; Vipin Kumar Singh; Vijay Tripathi; Krishna Kumar Choudhary; Awadhesh Kumar Shukla; Kumari Sunita; Ajay Kumar; Elza Bontempi; Ying Ma; Max Kolton; Amit Kishore Singh
Globally, substantial research into endophytic microbes is being conducted to increase agricultural and environmental sustainability. Endophytic microbes such as bacteria, actinomycetes, and fungi inhabit ubiquitously within the tissues of all plant species without causing any harm or disease. Endophytes form symbiotic relationships with diverse plant species and can regulate numerous host functions, including resistance to abiotic and biotic stresses, growth and development, and stimulating immune systems. Moreover, plant endophytes play a dominant role in nutrient cycling, biodegradation, and bioremediation, and are widely used in many industries. Endophytes have a stronger predisposition for enhancing mineral and metal solubility by cells through the secretion of organic acids with low molecular weight and metal-specific ligands (such as siderophores) that alter soil pH and boost binding activity. Finally, endophytes synthesize various bioactive compounds with high competence that are promising candidates for new drugs, antibiotics, and medicines. Bioprospecting of endophytic novel secondary metabolites has given momentum to sustainable agriculture for combating environmental stresses. Biotechnological interventions with the aid of endophytes played a pivotal role in crop improvement to mitigate biotic and abiotic stress conditions like drought, salinity, xenobiotic compounds, and heavy metals. Identification of putative genes from endophytes conferring resistance and tolerance to crop diseases, apart from those involved in the accumulation and degradation of contaminants, could open new avenues in agricultural research and development. Furthermore, a detailed molecular and biochemical understanding of endophyte entry and colonization strategy in the host would better help in manipulating crop productivity under changing climatic conditions. Therefore, the present review highlights current research trends based on the SCOPUS database, potential biotechnological interventions of endophytic microorganisms in combating environmental stresses influencing crop productivity, future opportunities of endophytes in improving plant stress tolerance, and their contribution to sustainable remediation of hazardous environmental contaminants. Graphical Abstract: [Figure not available: see fulltext.]. © 2023, The Author(s).
Distribution of cyanobacteria and their interactions with pesticides in paddy field: A comprehensive review
(Academic Press, 2018) Amit Kishore Singh; Prem Pratap Singh; Vijay Tripathi; Hariom Verma; Sandeep Kumar Singh; Akhileshwar Kumar Srivastava; Ajay Kumar
Cyanobacteria, also known as blue green algae are one of the important ubiquitous oxygen evolving photosynthetic prokaryotes and ultimate source of nitrogen for paddy fields since decades. In past two decades, indiscriminated use of pesticides led to biomagnification that intensively harm the structure and soil functions of soil microbes including cyanobacteria. Cyanobacterial abundance biomass, short generation, water holding capacity, mineralizing capacity and more importantly nitrogen fixing have enormous potential to abate the negative effects of pesticides. Therefore, investigation of the ecotoxicological effects of pesticides on the structure and function of the tropical paddy field associated cyanobacteria is urgent and need to estimate the fate of interaction of pesticides over nitrogen fixations and other attributes. In this regard, comprehensive survey over cyanobacterial distribution patterns and their interaction with pesticides in Indian context has been deeply reviewed. In addition, the present paper also deals the molecular docking pattern of pesticides with the nitrogen fixing proteins, which helps in revealing the functional interpretation over nitrogen fixation process. © 2018 Elsevier Ltd
Isolation and identification of Rhizospheric and Endophytic Bacteria from Cucumber plants irrigated with wastewater: Exploring their roles in plant growth promotion and disease suppression
(Elsevier Ltd, 2024) Kumar Shreshtha; Satyam Raj; Arun Kumar Pal; Pooja Tripathi; Krishna Kumar Choudhary; Debasis Mitra; Anju Rani; Sergio de los Santos-Villalobos; Vijay Tripathi
Wastewater contains various emerging contaminants, including heavy metals, residues of pesticides, and pharmaceuticals. Therefore, irrigation with wastewater can enhance heavy metal contamination in soil and adversely affect plant growth. To mitigate this problem, plant growth-promoting bacteria (PGPR) can improve plant growth under heavy metal stress. This study aimed to isolate and characterize rhizospheric and endophytic bacteria from the rhizosphere soil and roots of a cucumber plant irrigated with municipal wastewater. A total of 121 morphologically distinct bacterial isolates from the rhizosphere and 90 bacterial isolates from the endophytic region were isolated and tested for heavy metal resistance and in vitro plant growth-promoting characteristics, including indole-3-acetic acid (IAA) production, phosphate solubilization, Hydrogen Cyanide (HCN) production, and siderophore production. Most of the bacteria analyzed from the rhizospheric and endophytic regions showed various plant growth-promoting characteristics and were tolerant to different heavy metals at various concentrations. Bacterial strains R1 (Proteus sp.) and E2 (Bacillus sp.) were antagonistic to Fusarium oxysporum f. sp. Lycopersici. Wastewater irrigation increases heavy metal-resistant bacteria in cucumber plants, which can alleviate heavy metal stress. Additionally, Proteus sp. and Bacillus sp. isolates are potential candidates for removing heavy metal-contaminated soil and could be potential biofertilizer candidates for selected plants and biocontrol agents. © 2024 The Author(s)
Mitigating antibiotic pollution in wastewater by harnessing the potential of microalgae-based bioremediation technologies
(Springer, 2024) Amantika Singh; Pooja Singh; Jayant Kashyap; Pooja Tripathi; Krishna Kumar Choudhary; Pradeep Kumar Sharma; Rachan Karmakar; Maulin P. Shah; Vijay Tripathi
The excessive use of antibiotics and their increasing environmental concentrations is a severe threat and potential hazard to public health. Unfortunately, traditional wastewater treatment technologies aren’t efficient against antibiotic- and other emerging contaminant-rich wastewater. Recently, nature-based methods for wastewater treatment, such as algal-based technologies, have been observed to be viable and capable of the significant bioremediation of antibiotics in wastewater environments. Microalgae, including Scenedesmus quadricauda and Chlorella psychrophile, have already been reported as capable of absorbing and removing tetracycline and azithromycin antibiotics, respectively. Numerous algal species can also remove a significant proportion of different numbers of antibiotics through biodegradation when global wastewater pollution is at a record high. Microalgae may even affect the solubility of antibiotics through hydrolysis, leading to a breakdown of the β-lactam ring structure where present or through the resulting changes in pH, etc. This review provides critical insight into the important factors in removing antibiotic pollution from wastewater and enhancing the removal efficiency. © The Author(s) under exclusive licence to Society for Plant Research 2024.
Pharmacological properties, therapeutic potential, and legal status of Cannabis sativa L.: An overview
(John Wiley and Sons Ltd, 2021) Pradeep Kumar; Dipendra Kumar Mahato; Madhu Kamle; Rituraj Borah; Bharti Sharma; Shikha Pandhi; Vijay Tripathi; Hardeo Singh Yadav; Sheetal Devi; Umesh Patil; Jianbo Xiao; Awdhesh Kumar Mishra
Marijuana, or Cannabis sativa L., is a common psychoactive plant used for both recreational and medicinal purposes. In many countries, cannabis-based medicines have been legalized under certain conditions because of their immense prospects in medicinal applications. With a comprehensive insight into the prospects and challenges associated with the pharmacological use and global trade of C. sativa, this mini-review focuses on the medicinal importance of the plant and its legal status worldwide; the pharmacological compounds and its therapeutic potential along with the underlying public health concerns and future perspective are herein discussed. The existence of major compounds including Δ9-tetrahydrocannabinol (Δ9-THC), cannabidiol, cannabinol, and cannabichromene contributes to the medicinal effects of the cannabis plant. These compounds are also involved in the treatment of various types of cancer, epilepsy, and Parkinson's disease displaying several mechanisms of action. Cannabis sativa is a plant with significant pharmacological potential. However, several aspects of the plant need an in-depth understanding of the drug mechanism and its interaction with other drugs. Only after addressing these health concerns, legalization of cannabis could be utilized to its full potential as a future medicine. © 2021 John Wiley & Sons Ltd.
Plant Growth-Promoting Rhizobacteria (PGPR): Perspective in Agriculture Under Biotic and Abiotic Stress
(Elsevier, 2018) Ajay Kumar; Vipin K. Singh; Vijay Tripathi; Prem P. Singh; Amit K. Singh
Knowledge of rhizosphere ecology and its impact on plant physiology has dramatically changed traditional agricultural practices, especially in the context of plant defense mechanisms against biotic and abiotic stresses. It is a universally accepted fact that certain rhizosphere-associated strains, referred to as plant growth-promoting rhizobacteria (PGPR), stimulate plant growth and fitness. Since PGPR in symbiotic interactions are an integral part of the living ecosystem, they are believed to be the natural partners that modulate local and systemic mechanisms in plants to offer defense under adverse external conditions. PGPR producing secondary compounds that may act as signals—that is, allelochemicals—induce plant immunity against pathogen attack. Moreover, multifaceted role of PGPR is now being widely implemented for mitigating abiotic stress caused and induced by climate alternations and for restoring natural soil against variety of toxic metals. Future research demands interdisciplinary research that may pave the significant role of PGPR in modulating/introducing new crop traits under adverse conditions. © 2018 Elsevier B.V. All rights reserved.
Potential environmental and human health risks caused by antibiotic-resistant bacteria (ARB), antibiotic resistance genes (ARGs) and emerging contaminants (ECs) from municipal solid waste (MSW) landfill
(MDPI AG, 2021) Uttpal Anand; Bhaskar Reddy; Vipin Kumar Singh; Amit Kishore Singh; Kavindra Kumar Kesari; Pooja Tripathi; Pradeep Kumar; Vijay Tripathi; Jesus Simal-Gandara
The disposal of municipal solid waste (MSW) directly at landfills or open dump areas, without segregation and treatment, is a significant concern due to its hazardous contents of antibioticresistant bacteria (ARB), antibiotic resistance genes (ARGs), and metal resistance genes (MGEs). The released leachate from landfills greatly effects the soil physicochemical, biological, and groundwater properties associated with agricultural activity and human health. The abundance of ARB, ARGs, and MGEs have been reported worldwide, including MSW landfill sites, animal husbandry, wastewater, groundwater, soil, and aerosol. This review elucidates the occurrence and abundance of ARB, ARGs, and MRGs, which are regarded as emerging contaminants (ECs). Recently, ECs have received global attention because of their prevalence in leachate as a substantial threat to environmental and public health, including an economic burden for developing nations. The present review exclusively discusses the demands to develop a novel eco-friendly management strategy to combat these global issues. This review also gives an intrinsic discussion about the insights of different aspects of environmental and public health concerns caused due to massive leachate generation, the abundance of antibiotics resistance (AR), and the effects of released leachate on the various environmental reservoirs and human health. Furthermore, the current review throws light on the source and fate of different ECs of landfill leachate and their possible impact on the nearby environments (groundwater, surface water, and soil) affecting human health. The present review strongly suggests the demand for future research focuses on the advancement of the removal efficiency of contaminants with the improvement of relevant landfill management to reduce the potential effects of disposable waste. We propose the necessity of the identification and monitoring of potential environmental and human health risks associated with landfill leachate contaminants. © 2021 by the authors.