Browsing by Author "Vikas Singh"

Now showing 1 - 8 of 8

Abdominal herniation associated with bullhorn injury as a separate entity from traumatic abdominal wall hernias
(Wolters Kluwer Medknow Publications, 2018) Singh Kaushal-Deep; Vikas Singh; Poonam Gupta; Rudra Mani; Mehershree Lodhi
Bullhorn injury is a rare mechanism causing traumatic abdominal wall hernia (TAWH). Bullhorn injury needs to be discussed as a separate sub-entity among TAWHs as the mechanism of injury is such that the great force is generated at a relatively small area of impact for a short duration of time which may lead to muscle defect without compromising integrity of overlying skin (referred to as sheathed goring) leading to herniation of abdominal viscera. The purpose of this review was to discuss abdominal herniation's associated with bullhorn injury as a separate entity from TAWHs; recognize the common presentations, mechanism of injury, and modalities of treatment currently utilized for this rare condition. A comprehensive online English, Spanish, Portuguese, and French language medical literature search was done using various electronic search databases. Different search terms including MeSH related to bullhorn-injury associated injuries including abdominal wall hernias were used. An advanced search was further conducted by combining all the search fields in abstracts, keywords, and titles. We summarized the data from the searched articles and found 12 cases who underwent emergency or elective herniorrhaphy with or without the use of mesh. We have proposed a treatment algorithm for such cases in light of the present era of laparoscopy and propose the usage of the term 'bullhorn-injury associated traumatic hernia' for such cases. We present here the first most comprehensive discussion of all such cases reported till date. © 2018 Journal of Research in Medical Sciences - Published by Wolters Kluwer - Medknow.
Enhanced sustained release of furosemide in long circulating chitosan-conjugated PLGA nanoparticles
(Wolters Kluwer Medknow Publications, 2019) Sapna Kashyap; Amit Singh; Abha Mishra; Vikas Singh
Furosemide (FSM) is commonly used in the treatment of edema associated with congestive cardiac failure, cirrhosis of the liver, renal disease, including the nephrotic syndrome and hypertension. However, in ascites, it is clinically limited due to its frequent dosing and short biological half-life and its prolonged-release preparations are not available. Therefore, the main objective behind the present research work is to develop chitosan coated and conjugated poly (lactic-co-glycolic acid) (PLGA) nanocarriers, to sustain the delivery of FSM with improved systemic circulation. Emulsion-solvent evaporation technique was used for the preparation of nanoparticles. In-vivo pharmacokinetic study showed 2.6, 3.10, and 4.30 folds enhancement in relative availability of FSM for FSM-PLGA, FSM-chitosan-coated-PLGA and FSM-chitosan-conjugated-PLGA nanoparticles, respectively than FSM. The present research work concluded that FSM loaded chitosan conjugated PLGA nanoparticles could enhance the systemic circulation of FSM with improved pharmacokinetics parameters. © 2019 Medknow Publications.All rights reserved.
Erratum: Is treatment with platelet-rich fibrin better than zinc oxide eugenol in cases of established dry socket for controlling pain, reducing inflammation, and improving wound healing? (J Korean Assoc Oral Maxillofac Surg(2019)45 (76-82)Doi: 10.5125/jkaoms.2019.45.2.76)
(Korean Association of Oral and Maxillofacial Surgeons, 2019) Sam Paul; Rupshikha Choudhury; Nandini Kumari; Sanjay Rastogi; Ashish Sharma; Vikas Singh; Shyamalendu Laskar; Tushar Dubey
This article has been retracted at the request of the Editorial Board. The Editorial Board consulted with the KAMJE (Korean Association of Medical Journal Editors) about 'Imalas' matter of the publication and concluded as following: The Paper A1 is an article on the study of pain, inflammation and formation of granulation tissue using platelet rich fibrin (PRF) for dry socket treatment after tooth extraction. This study was conducted on 100 patients at Teerthankar Mahaveer Dental College and Research Center, Moradabad, from September 2014 to March 2016. The Paper B2 is a research based on the same conditions as Paper A1. This study was conducted on 100 patients using PRF and 100 patients using zinc oxide eugenol, from August 2014 to December 2017. The study was held at the Kothiwal Dental College and Research Centre (KDCRC), Moradabad. The clinical factors studied in above two articles are the same, and the pain scale in Fig. 3 in Paper A1 is almost identical to the Fig. 2, Group A in Paper B2; and Fig. 5 in Paper A1 is also same as Fig. 4, Group A in Paper B2. Both papers are judged to have the overlapping publication in the similar period and the patient, and it is considered intentional not to cite Paper A1 in Paper B2. Therefore, Paper B2 is believed to be a significant double publication. For this reason, the Editorial Board decided to retracted this article and sincerely apologize for any inconvenience this may have caused. © 2019 The Korean Association of Oral and Maxillofacial Surgeons. All rights reserved.
Healing of Artificially Created Gap Non-union Using Autologous Cultured Osteoblasts Impregnated Over Three-Dimensional Biodegradable Scaffold: An Experimental Study (Rabbit)
(Springer, 2021) Vikas Singh; Mahipat Singh; Rupesh Jung Belbase; Amit Rastogi
Background: The large bone defect often require bone transplant or its substitutes to restore bone integrity which have some limitations. The study was conducted to analyze role of autologous osteoblast that are amplified in vivo and impregnated in a synthesized three-dimensional gelatin hydroxyapatite scaffold for treating artificially created critical size defect in rabbit's iliac crest. Methods: In this research, 4-month-old ten healthy white male rabbits of average weight 2–3 kg were chosen. Osteoblasts cells were isolated from the rabbit iliac crest and were taken in transfer medium to the laboratory and cultured for 2–3 weeks. These osteoblast cells were seed on 3-dimensional scaffold and culture the construct for 2 weeks. The cultured autologous osteoblasts over the scaffold were transplanted into the defect by reopening the iliac crest of the same rabbit from which is cells were extracted. Serial radiograph of pelvis was done to see progressive signs of union. Results: Out of ten rabbits chosen for study two rabbits were passed during study. Gross and radiological examination of rabbits was done at 0, 4, 8 and 12 weeks. Features of union was seen in six rabbits on follow-up. There is no signs of union or minimal new bone formation around the implant material were seen in two case. Conclusion: The study demonstrated using autologous cultured osteoblasts impregnated over three-dimensional biodegradable scaffold for large bone defect is a good option. The importance of three-dimensional biodegradable scaffold is that it provide scaffolding for sufficient interval for new bone formation. © 2021, Indian Orthopaedics Association.
Is treatment with platelet-rich fibrin better than zinc oxide eugenol in cases of established dry socket for controlling pain, reducing inflammation, and improving wound healing?
(Korean Association of Oral and Maxillofacial Surgeons, 2019) Sam Paul; Rupshikha Choudhury; Nandini Kumari; Sanjay Rastogi; Ashish Sharma; Vikas Singh; Shyamalendu Laskar; Tushar Dubey
Objectives: To appraise the effectiveness of platelet-rich fibrin (PRF) in the management of established dry socket in terms of pain, inflammation, and wound healing. Materials and Methods: Two hundred patients with established alveolar osteitis were studied to determine the efficacy of PRF and zinc oxide eugenol (ZOE) for pain control, inflammation reduction, and wound healing. Patients were randomly allocated to Group A (PRF) or Group B (ZOE). Patients were examined on the 1st, 3rd, 7th, and 14th postoperative day and evaluated for pain using visual analogue scale scores, inflammation with a gingival index score, and wound healing through a determination of the number of bony walls exposed. Results: Group A showed better results in terms of pain remission, control of inflammation, and wound healing compared to Group B. Results between groups were statistically significant (P<0.05). Conclusion: PRF is a better alternative than ZOE for the effective management of alveolar osteitis. © 2019 The Korean Association of Oral and Maxillofacial Surgeons. All rights reserved.
Plant Secondary Metabolites as Defense Tools against Herbivores for Sustainable Crop Protection
(MDPI, 2022) Pratap Adinath Divekar; Srinivasa Narayana; Bhupendra Adinath Divekar; Rajeev Kumar; Basana Gowda Gadratagi; Aishwarya Ray; Achuit Kumar Singh; Vijaya Rani; Vikas Singh; Akhilesh Kumar Singh; Amit Kumar; Rudra Pratap Singh; Radhe Shyam Meena; Tusar Kanti Behera
Plants have evolved several adaptive strategies through physiological changes in response to herbivore attacks. Plant secondary metabolites (PSMs) are synthesized to provide defensive functions and regulate defense signaling pathways to safeguard plants against herbivores. Herbivore injury initiates complex reactions which ultimately lead to synthesis and accumulation of PSMs. The biosynthesis of these metabolites is regulated by the interplay of signaling molecules comprising phytohormones. Plant volatile metabolites are released upon herbivore attack and are capable of directly inducing or priming hormonal defense signaling pathways. Secondary metabolites enable plants to quickly detect herbivore attacks and respond in a timely way in a rapidly changing scenario of pest and environment. Several studies have suggested that the potential for adaptation and/or resistance by insect herbivores to secondary metabolites is limited. These metabolites cause direct toxicity to insect pests, stimulate antixenosis mechanisms in plants to insect herbivores, and, by recruiting herbivore natural enemies, indirectly protect the plants. Herbivores adapt to secondary metabolites by the up/down regulation of sensory genes, and sequestration or detoxification of toxic metabolites. PSMs modulate multi-trophic interactions involving host plants, herbivores, natural enemies and pollinators. Although the role of secondary metabolites in plant-pollinator interplay has been little explored, several reports suggest that both plants and pollinators are mutually benefited. Molecular insights into the regulatory proteins and genes involved in the biosynthesis of secondary metabolites will pave the way for the metabolic engineering of biosynthetic pathway intermediates for improving plant tolerance to herbivores. This review throws light on the role of PSMs in modulating multi-trophic interactions, contributing to the knowledge of plant-herbivore interactions to enable their management in an eco-friendly and sustainable manner. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Retraction : Is treatment with platelet-rich fibrin better than zinc oxide eugenol in cases of established dry socket for controlling pain, reducing inflammation, and improving wound healing? (Korean oral and maxillofacial surgery (2019) 45 (76-82) DOI: 10.5125/jkaoms.2019.45.2.76)
(Korean Association of Oral and Maxillofacial Surgeons, 2019) Sam Paul; Rupshikha Choudhury; Nandini Kumari; Sanjay Rastogi; Ashish Sharma; Vikas Singh; Shyamalendu Laskar; Tushar Dubey
This article has been retracted at the request of the Editorial Board. The Editorial Board consulted with the KAMJE (Korean Association of Medical Journal Editors) about 'Imalas' matter of the publication and concluded as following: The Paper A1 is an article on the study of pain, inflammation and formation of granulation tissue using platelet rich fibrin (PRF) for dry socket treatment after tooth extraction. This study was conducted on 100 patients at Teerthankar Mahaveer Dental College and Research Center, Moradabad, from September 2014 to March 2016. The Paper B2 is a research based on the same conditions as Paper A1. This study was conducted on 100 patients using PRF and 100 patients using zinc oxide eugenol, from August 2014 to December 2017. The study was held at the Kothiwal Dental College and Research Centre (KDCRC), Moradabad. The clinical factors studied in above two articles are the same, and the pain scale in Fig. 3 in Paper A1 is almost identical to the Fig. 2, Group A in Paper B2; and Fig. 5 in Paper A1 is also same as Fig. 4, Group A in Paper B2. Both papers are judged to have the overlapping publication in the similar period and the patient, and it is considered intentional not to cite Paper A1 in Paper B2. Therefore, Paper B2 is believed to be a significant double publication. For this reason, the Editorial Board decided to retracted this article and sincerely apologize for any inconvenience this may have caused. © 2019 Korean Association of Oral and Maxillofacial Surgeons. All rights reserved.
Simulation skill of APCC set of global climate models for Asian summer monsoon rainfall variability
(Springer-Verlag Wien, 2015) U.K. Singh; G.P. Singh; Vikas Singh
The performance of 11 Asia-Pacific Economic Cooperation Climate Center (APCC) global climate models (coupled and uncoupled both) in simulating the seasonal summer (June–August) monsoon rainfall variability over Asia (especially over India and East Asia) has been evaluated in detail using hind-cast data (3 months advance) generated from APCC which provides the regional climate information product services based on multi-model ensemble dynamical seasonal prediction systems. The skill of each global climate model over Asia was tested separately in detail for the period of 21 years (1983–2003), and simulated Asian summer monsoon rainfall (ASMR) has been verified using various statistical measures for Indian and East Asian land masses separately. The analysis found a large variation in spatial ASMR simulated with uncoupled model compared to coupled models (like Predictive Ocean Atmosphere Model for Australia, National Centers for Environmental Prediction and Japan Meteorological Agency). The simulated ASMR in coupled model was closer to Climate Prediction Centre Merged Analysis of Precipitation (CMAP) compared to uncoupled models although the amount of ASMR was underestimated in both models. Analysis also found a high spread in simulated ASMR among the ensemble members (suggesting that the model’s performance is highly dependent on its initial conditions). The correlation analysis between sea surface temperature (SST) and ASMR shows that that the coupled models are strongly associated with ASMR compared to the uncoupled models (suggesting that air-sea interaction is well cared in coupled models). The analysis of rainfall using various statistical measures suggests that the multi-model ensemble (MME) performed better compared to individual model and also separate study indicate that Indian and East Asian land masses are more useful compared to Asia monsoon rainfall as a whole. The results of various statistical measures like skill of multi-model ensemble, large spread among the ensemble members of individual model, strong teleconnection (correlation analysis) with SST, coefficient of variation, inter-annual variability, analysis of Taylor diagram, etc. suggest that there is a need to improve coupled model instead of uncoupled model for the development of a better dynamical seasonal forecast system. © 2014, Springer-Verlag Wien.