Browsing by Author "Virendra Singh"

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A Facile Synthesis of Flower-like Iron Oxide Nanoparticles and Its Efficacy Measurements for Antibacterial, Cytotoxicity and Antioxidant Activity
(Multidisciplinary Digital Publishing Institute (MDPI), 2023) Nazish Tabassum; Virendra Singh; Vivek K. Chaturvedi; Emanuel Vamanu; Mohan P. Singh
The objective of this study was to investigate the rhombohedral-structured, flower-like iron oxide (Fe2O3) nanoparticles that were produced using a cost-effective and environmentally friendly coprecipitation process. The structural and morphological characteristics of the synthesized Fe2O3 nanoparticles were analyzed using XRD, UV-Vis, FTIR, SEM, EDX, TEM, and HR-TEM techniques. Furthermore, the cytotoxic effects of Fe2O3 nanoparticles on MCF-7 and HEK-293 cells were evaluated using in vitro cell viability assays, while the antibacterial activity of the nanoparticles against Gram-positive and Gram-negative bacteria (Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae) was also tested. The results of our study demonstrated the potential cytotoxic activity of Fe2O3 nanoparticles toward MCF-7 and HEK-293 cell lines. The antioxidant potential of Fe2O3 nanoparticles was evidenced by the 1,1-diphenyl-2-picrylhydrazine (DPPH) and nitric oxide (NO) free radical scavenging assays. In addition, we suggested that Fe2O3 nanoparticles could be used in various antibacterial applications to prevent the spread of different bacterial strains. Based on these findings, we concluded that Fe2O3 nanoparticles have great potential for use in pharmaceutical and biological applications. The effective biocatalytic activity of Fe2O3 nanoparticles recommends its use as one of the best drug treatments for future views against cancer cells, and it is, therefore, recommended for both in vitro and in vivo in the biomedical field. © 2023 by the authors.
Accessing the socio-economic grade of menthol growers in India: Shifting from traditional farming to income based farming
(IndianJournals.com, 2018) Harshika Choudhary; P.S. Badal; Virendra Singh; Amita Maurya
The Mentha arvensis is an important essential oil bearing plant and widely used in food, flavour, pharmaceutical and cosmetic industries. Amongst the Aromatic crops, mentha is important crop as India is the largest producer, consumer as well as exporter of mentha. The present study was conducted in Rampur district of Uttar Pradesh with the objective to find out socio-economic condition of farmers in mentha cultivation. Multi-stage sampling technique was used to select blocks, villages and the respondents from the four villages of two blocks of Rampur district. The results revealed that majority of mentha growing farmers were in the middle age group (31–50 years) at aggregate level. Average family size at aggregate level was 5.01. The majority of the farmers were educated (86.67). The major investment item was tractor, which on aggregate level covers 47.81 per cent of total investment. Farm building and storage structure contributes 29.18 per cent at aggregate level. © 2018, IndianJournals.com. All rights reserved.
Antibacterial Photodynamic Therapy by Zn(II)-Curcumin Complex: Synthesis, Characterization, DFT Calculation, Antibacterial Activity, and Molecular Docking
(John Wiley and Sons Inc, 2024) Rajesh Kushwaha; Rohit Rai; Vedant Gawande; Virendra Singh; Ashish Kumar Yadav; Biplob Koch; Prodyut Dhar; Samya Banerjee
The increase in antibacterial drug resistance is threatening global health conditions. Recently, antibacterial photodynamic therapy (aPDT) has emerged as an effective antibacterial treatment with high cure gain. In this work, three Zn(II) complexes viz., [Zn(en)(acac)Cl] (1), [Zn(bpy)(acac)Cl] (2), [Zn(en)(cur)Cl] (3), where en=ethylenediamine (1 and 3), bpy=2,2’-bipyridine (2), acac=acetylacetonate (1 and 2), cur=curcumin monoanionic (3) were developed as aPDT agents. Complexes 1–3 were synthesized and fully characterized using NMR, HRMS, FTIR, UV-Vis. and fluorescence spectroscopy. The HOMO–LUMO energy gap (Eg), and adiabatic splittings (ΔS1−T1 and ΔS0−T1) obtained from DFT calculation indicated the photosensivity of the complexes. These complexes have not shown any potent antibacterial activity under dark conditions but the antibacterial activity of these complexes was significantly enhanced upon light exposure (MIC value up to 0.025 μg/mL) due to their light-mediated 1O2 generation abilities. The molecular docking study suggested that complexes 1–3 interact efficiently with DNA gyrase B (PDB ID: 4uro). Importantly, 1–3 did not show any toxicity toward normal HEK-293 cells. Overall, in this work, we have demonstrated the promising potential of Zn(II) complexes as effective antibacterial agents under the influence of visible light. © 2023 Wiley-VCH GmbH.
Aqua-(2-formylbenzoato)triphenyltin(IV) induces cell cycle arrest and apoptosis in hypoxic triple negative breast cancer cells
(Elsevier Ltd, 2023) Virendra Singh; Nishant Kumar Rana; Mohammad Kashif; Partha Pratim Manna; Tushar S. Basu Baul; Biplob Koch
Hypoxia plays a vital role in tumor microenvironment by allowing development and maintenance of cancer cells thereby led to major hindrance for effective anticancer therapy and main reason for failure of most anticancer drugs. We herein investigated the therapeutic efficacy and molecular mechanism of action of aqua-(2-formylbenzoato) triphenyltin (IV) compound (OTC) in MDA-MB-231 cell line. Cobalt chloride induced hypoxic MDA-MB-231 cells treated with OTC were used to access cytotoxicity, ROS, cellular apoptosis, and cell cycle progression. Further, expression of HIF-1α and VEGF, as well as apoptotic proteins like p53, Bax, Bcl-2 and caspase 3 were assessed. The findings indicated that OTC is more effective towards CoCl2 induced hypoxic cells when compared to normoxic cells and the results are far superior to doxorubicin. Additionally, our study revealed that OTC facilitates more ROS production induced cell cycle arrest and promote apoptosis. Furthermore, OTC significantly down regulates the expression of Hif-1α, VEGF and Bcl-2 in hypoxic condition and elevates the level of p53, Bax, cytochrome-C and Caspase 3. Our in vitro studies demonstrated that OTC showed better efficacy than doxorubicin, corroborating that OTC could be a promising compound for hypoxic cancer that also display multi drug resistant. © 2022 Elsevier Ltd
Association of single nucleotide polymorphisms in CYP1B1 and COMT genes with breast cancer susceptibility in Indian women
(Hindawi Limited, 2009) Sharawan Yadav; Naveen Kumar Singhal; Virendra Singh; Neeraj Rastogi; Pramod Kumar Srivastava; Mahendra Pratap Singh
Cytochrome P450 1B1 (CYP1B1) and catechol-$O$- methyltransferase (COMT) enzymes play critical roles in estrogen metabolism. Alterations in the catalytic activity of CYP1B1 and COMT enzymes have been found associated with altered breast cancer risk in postmenopausal women in many populations. The substitution of leucine (Leu) to valine (Val) at codon 432 increases the catalytic activity of CYP1B1, however, substitution of Val to methionine (Met) at codon 158 decreases the catalytic activity of COMT. The present study was performed to evaluate the associations of CYP1B1 Leu 432Val and/or COMT Val158Met polymorphisms with total, premenopausal and postmenopausal breast cancer risks in Indian women. COMT and CYP1B1 polymorphisms in controls and breast cancer patients were analyzed employing polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) followed by gel electrophoresis. Although CYP1B1 and COMT genotypes did not exhibit statistically significant association with breast cancer risks when analyzed individually, COMT wild type (Val158Val) in combination with CYP1B1 heterozygous variant (Leu432Val) [OR: 0.21; 95% CI (0.05-0.82), p value; 0.021] and COMT heterozygous variant (Val 158Met) in combination with CYP1B1 wild type (Leu432Leu) [OR: 0.29; 95% CI (0.08-0.96), p value; 0.042] showed significant protective association with premenopausal breast cancer risk. The results demonstrate that CYP1B1 wild type in combination with COMT heterozygous or their inverse combination offer protection against breast cancer in premenopausal Indian women. © 2009 - IOS Press and the authors. All rights reserved.
Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017 (Nature Medicine, (2020), 26, 5, (750-759), 10.1038/s41591-020-0807-6)
(Nature Research, 2020) Damaris K. Kinyoki; Jennifer M. Ross; Alice Lazzar-Atwood; Sandra B. Munro; Lauren E. Schaeffer; Mahdieh Abbasalizad-Farhangi; Masoumeh Abbasi; Hedayat Abbastabar; Ahmed Abdelalim; Amir Abdoli; Mohammad Abdollahi; Ibrahim Abdollahpour; Rizwan Suliankatchi Abdulkader; Nebiyu Dereje Abebe; Teshome Abuka Abebo; Kedir Hussein Abegaz; Hassan Abolhassani; Lucas Guimarães Abreu; Michael R. M. Abrigo; Abdelrahman I. Abushouk; Manfred Mario Kokou Accrombessi; Dilaram Acharya; Maryam Adabi; Akindele Olupelumi Adebiyi; Isaac Akinkunmi Adedeji; Victor Adekanmbi; Abiodun Moshood Adeoye; Olatunji O. Adetokunboh; Davoud Adham; Posi Emmanuel Aduroja; Shailesh M. Advani; Mohsen Afarideh; Mohammad Aghaali; Anurag Agrawal; Tauseef Ahmad; Keivan Ahmadi; Sepideh Ahmadi; Muktar Beshir Ahmed; Rushdia Ahmed; Olufemi Ajumobi; Chalachew Genet Akal; Temesgen Yihunie Akalu; Tomi Akinyemiju; Blessing Akombi; Ziyad Al-Aly; Samiah Alam; Genet Melak Alamene; Turki M. Alanzi; Jacqueline Elizabeth Alcalde Rabanal; Niguse Meles Alema; Beriwan Abdulqadir Ali; Muhammad Ali; Mehran Alijanzadeh; Cyrus Alinia; Vahid Alipour; Hesam Alizade; Syed Mohamed Aljunid; Afshin Almasi; Amir Almasi-Hashiani; Hesham M. Al-Mekhlafi; Rajaa M. Al-Raddadi; Khalid Altirkawi; Nelson Alvis-Guzman; Nelson J. Alvis-Zakzuk; Azmeraw T. Amare; Adeladza Kofi Amegah; Saeed Amini; Mostafa Amini Rarani; Fatemeh Amiri; Arianna Maever Loreche Amit; Nahla Hamed Anber; Catalina Liliana Andrei; Fereshteh Ansari; Alireza Ansari-Moghaddam; Zelalem Alamrew Anteneh; Carl Abelardo T. Antonio; Ernoiz Antriyandarti; Davood Anvari; Razique Anwer; Seth Christopher Yaw Appiah; Jalal Arabloo; Morteza Arab-Zozani; Ephrem Mebrahtu Araya; Zohreh Arefi; Olatunde Aremu; Johan Ärnlöv; Afsaneh Arzani; Mehran Asadi-Aliabadi; Ali A. Asadi-Pooya; Samaneh Asgari; Babak Asghari; Alebachew Fasil Ashagre; Anemaw A. Asrat; Bahar Ataeinia; Hagos Tasew Atalay; Desta Debalkie Atnafu; Maha Moh’d Wahbi Atout; Marcel Ausloos; Euripide F. G. A. Avokpaho; Ashish Awasthi; Beatriz Paulina Ayala Quintanilla; Martin Amogre Ayanore; Yared A. Asmare Aynalem; Abbas Azadmehr; Samad Azari; Ghasem Azarian; Zelalem Nigussie Azene; Ebrahim Babaee; Alaa Badawi; Ashish D. Badiye; Mohamad Amin Bahrami; Atif Amin A. Baig; Ahad Bakhtiari; Shankar M. Bakkannavar; Senthilkumar Balakrishnan; Ayele Geleto Bali; Maciej Banach; Palash Chandra Banik; Zahra Baradaran-Seyed; Adhanom Gebreegziabher Baraki; Miguel A. Barboza; Till Winfried Bärnighausen; Lingkan Barua; Huda Basaleem; Sanjay Basu; Mohsen Bayati; Mulat Tirfie Bayih; Habtamu Wondifraw Baynes; Neeraj Bedi; Masoud Behzadifar; Meysam Behzadifar; Yibeltal Alemu Bekele; Derrick A. Bennett; Dessalegn Ajema Berbada; Kidanemaryam Berhe; Abadi Kidanemariam Berhe; Adam E. Berman; Robert S. Bernstein; Reshmi Bhageerathy; Dinesh Bhandari; Pankaj Bharadwaj; Natalia V. Bhattacharjee; Krittika Bhattacharyya; Ali Bijani; Boris Bikbov; Ver Bilano; Nigus Bililign; Muhammad Shahdaat Bin Sayeed; Setognal Birara; Minuye Biniam Biniam Birhane; Minyichil Birhanu; Raaj Kishore Biswas; Zebenay Workneh Bitew; Kassawmar Angaw Bogale; Somayeh Bohlouli; Srinivasa Rao Bolla; Archith Boloor; Antonio M. Borzì; Shiva Borzouei; Oliver J. Brady; Nicola Luigi Bragazzi; Dejana Braithwaite; Nikolay Ivanovich Briko; Gabrielle Britton; Shyam S. Budhathoki; Sharath Burugina Nagaraja; Reinhard Busse; Zahid A. Butt; Lucero Cahuana-Hurtado; Luis Alberto Cámera; Ismael R. Campos-Nonato; Jorge Cano; Josip Car; Rosario Cárdenas; Juan J. Carrero; Félix Carvalho; João Mauricio Castaldelli-Maia; Carlos A. Castañeda-Orjuela; Franz Castro; Ester Cerin; Collins Chansa; Jaykaran Charan; Pranab Chatterjee; Vijay Kumar Chattu; Bal Govind Chauhan; Ali Reza Chavshin; Mohammad Chehrazi; Tesfaye Yitna Chichiabellu; Ken Lee Chin; Devasahayam J. Christopher; Dinh-Toi Chu; Flavia M. Cicuttini; Michael L. Collison; Michael A. Cork; Natalie Cormier; Paolo Angelo Cortesi; Vera M. Costa; Abel Fekadu Fekadu Dadi; Baye Dagnew; Saad M. A. Dahlawi; Giovanni Damiani; Amira Hamed Darwish; Ahmad Daryani; Jai K. Das; Rajat Das Gupta; Claudio Dávila-Cervantes; Nicole Davis Weaver; Diego De Leo; Jan-Walter De Neve; Feleke Mekonnen Demeke; Asmamaw Bizuneh Demis; Dereje Bayissa Demissie; Gebre Teklemariam Demoz; Edgar Denova-Gutiérrez; Kebede Deribe; Rupak Desai; Beruk Berhanu Desalegn; Assefa Desalew; Aniruddha Deshpande; Sagnik Dey; Samath Dhamminda Dharmaratne; Preeti Dhillon; Meghnath Dhimal; Govinda Prasad Dhungana; Mostafa Dianati Nasab; Daniel Diaz; Zahra Sadat Dibaji Forooshani; Girmaye Deye Dinsa; Isaac Oluwafemi Dipeolu; Shirin Djalalinia; Hoa Thi Do; Huyen Phuc Do; Paul Narh Doku; Fariba Dorostkar; Leila Doshmangir; Manisha Dubey; Bereket Duko Adema; Susanna J. Dunachie; Bruce B. Duncan; Ewerton Cousin; Andre R. Durães; Lucas Earl; Hamed Ebrahimzadeh Leylabadlo; Aziz Eftekhari; Iman El Sayed; Maysaa El Sayed Zaki; Maha El Tantawi; Iffat Elbarazi; Demelash Abewa Elemineh; Shaimaa I. El-Jaafary; Ziad El-Khatib; Aisha Elsharkawy; Yasser Mohamed El-Sherbiny; Iqbal R. F. Elyazar; Mohammad Hassan Emamian; Shymaa Enany; Daniel Adane Endalew; Melese Linger Endalifer; Khalil Eskandari; Sharareh Eskandarieh; Saman Esmaeilnejad; Alireza Esteghamati; Arash Etemadi; Atkilt Esaiyas Etisso; Jessica Fanzo; Mohammad Farahmand; Anwar Faraj; Sajjad Farashi; Mohammad Fareed; Andrea Farioli; Andre Faro; Farshad Farzadfar; Hossein Farzam; Syeda Sadia Fatima; Nazir Fattahi; Nelsensius Klau Fauk; Ali Akbar Fazaeli; Netsanet Fentahun; Tomas Y. Ferede; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; João C. Fernandes; Garumma Tolu Feyissa; Irina Filip; Florian Fischer; Carsten Flohr; Nataliya A. Foigt; Morenike Oluwatoyin Folayan; Artem Alekseevich Fomenkov; Masoud Foroutan; Jana Förster; Joel Msafiri Francis; Takeshi Fukumoto; Reta Tsegaye Gayesa; Biniyam Sahiledengle Geberemariyam; Tsegaye Tewelde Gebrehiwot; Hadush Gebremariam; Kidane Tadesse Gebremariam; Ketema Bizuwork Bizuwork Gebremedhin; Gebreamlak Gebremedhn Gebremeskel; Assefa Ayalew Ayalew Gebreslassie; Gebretsadkan G. G. Gebretsadik; Getnet Azeze Gedefaw; Yilma Chisha Dea Geramo; Hailay Abrha Gesesew; Birhanu Geta; Agegnehu Bante Getenet; Kebede Embaye Gezae; Fatemeh Ghaffarifar; Mansour Ghafourifard; Alireza Ghajar; Mahsa Ghajarzadeh; Ahmad Ghashghaee; Hesam Ghiasvand; Asadollah Gholamian; Syed Amir Gilani; Tiffany K. Gill; Ibrahim Abdelmageed Ginawi; Srinivas Goli; Nelson G. M. Gomes; Sameer Vali Gopalani; Houman Goudarzi; Alessandra C. Goulart; Arunkumar Govindakarnavar; Ayman Grada; Michal Grivna; Rafael Alves Guimarães; Rashid Abdi Guled; Yuming Guo; Rahul Gupta; Rajeev Gupta; Nima Hafezi-Nejad; Michael Tamene Haile; Arvin Haj-Mirzaian; Arya Haj-Mirzaian; Brian J. Hall; Iman Halvaei; Randah R. Hamadeh; Yadollah Hamidi; Demelash Woldeyohannes Handiso; Graeme J. Hankey; Hamidreza Haririan; Ninuk Hariyani; Ahmed I. Hasaballah; Md. Mehedi Hasan; Milad Hasankhani; Edris Hasanpoor; Amir Hasanzadeh; Maryam Hashemian; Soheil Hassanipour; Hamid Yimam Hassen; Rasmus Havmoeller; Corinna Hawkes; Khezar Hayat; Desta Haftu Hayelom; Behnam Heidari; Reza Heidari-Soureshjani; Delia Hendrie; Andualem Henok; Nathaniel J. Henry; Mario Herrero; Claudiu Herteliu; Fatemeh Heydarpour; Hagos D. de Hidru; Chi Linh Hoang; Hans W. Hoek; Michael K. Hole; Ramesh Holla; Gillian Hollerich; Enayatollah Homaie Rad; Sung Hwi Hong; Praveen Hoogar; Masako Horino; Naznin Hossain; Mostafa Hosseini; Mehdi Hosseinzadeh; Mihaela Hostiuc; Sorin Hostiuc; Mowafa Househ; Mohamed Hsairi; Guoqing Hu; Tanvir M. Huda; Ayesha Humayun; Bing-Fang Hwang; Segun Emmanuel Ibitoye; Olayinka Stephen Ilesanmi; Milena D. Ilic; Mohammad Hasan Imani-Nasab; Leeberk Raja Inbaraj; Usman Iqbal; Seyed Sina Naghibi Irvani; Sheikh Mohammed Shariful Islam; Chidozie C. D. Iwu; Chinwe Juliana Iwu; Neda Izadi; Jalil Jaafari; Anelisa Jaca; Farhad Jadidi-Niaragh; Nader Jafari Balalami; Morteza Jafarinia; Mohammad Ali Jahani; Mihajlo Jakovljevic; Amir Jalali; Farzad Jalilian; Achala Upendra Jayatilleke; Panniyammakal Jeemon; Fyezah Jehan; Ensiyeh Jenabi; Ravi Prakash Jha; Vivekanand Jha; John S. Ji; Peng Jia; Oommen John; Yetunde O. John-Akinola; Kimberly B. Johnson; Jost B. Jonas; Nitin Joseph; Farahnaz Joukar; Jacek Jerzy Jozwiak; Suresh Banayya Jungari; Mikk Jürisson; Ali Kabir; Zubair Kabir; Amaha Kahsay; Molla Kahssay; Hamed Kalani; Leila L. Kalankesh; Rohollah Kalhor; Zahra Kamiab; Tanuj Kanchan; Umesh Kapil; Neeti Kapoor; Manoochehr Karami; Behzad Karami Matin; André Karch; Mohd A. Karim; Surendra Karki; Amir Kasaeian; Gebremicheal Gebreslassie Kasahun; Habtamu Kebebe Kasaye; Tesfaye Dessale Kassa; Hagazi Gebremedhin Kassaye; Nicholas J. Kassebaum; Ali Kazemi Karyani; Andre Pascal Kengne; Daniel Bekele Ketema; Yousef Saleh Khader; Morteza Abdullatif Khafaie; Mojtaba Khaksarian; Nauman Khalid; Ibrahim A. Khalil; Rovshan Khalilov; Asad Khan; Ejaz Ahmad Khan; Md Nuruzzaman Khan; Mohammad Saud Khan; Muhammad Shahzeb Khan; Khaled Khatab; Amir Khater; Mona M. Khater; Mahalqua Nazli Khatib; Maryam Khayamzadeh; Maryam Khazaei-Pool; Mohammad Khazaei; Salman Khazaei; Mohammad Taghi Khodayari; Mohammad Hossein Khosravi; Roba Khundkar; Ali Kiadaliri; Neda Kianipour; Daniel N. Kiirithio; Yun Jin Kim; Ruth W. Kimokoti; Adnan Kisa; Sezer Kisa; Tufa Kolola; Hamidreza Komaki; Shivakumar K. M. Kondlahalli; Ali Koolivand; Parvaiz A. Koul; Ai Koyanagi; Moritz U. G. Kraemer; Kewal Krishan; Kris J. Krohn; Nuworza Kugbey; Manasi Kumar; Pushpendra Kumar; Vivek Kumar; Om P. Kurmi; Oluwatosin Kuti; Carlo La Vecchia; Ben Lacey; Deepesh P. Lad; Aparna Lal; Dharmesh Kumar Lal; Faris Hasan Lami; Prabhat Lamichhane; Justin J. Lang; Van C. Lansingh; Savita Lasrado; Georgy Lebedev; Paul H. Lee; Shaun Wen Huey Lee; Mostafa Leili; Ian D. Letourneau; Sonia Lewycka; Shanshan Li; Lee-Ling Lim; Shai Linn; Shiwei Liu; Simin Liu; Rakesh Lodha; Joshua Longbottom; Jaifred Christian F. Lopez; Stefan Lorkowski; Erlyn Rachelle King Macarayan; Mohammed Madadin; Hassan Magdy Abd El Razek; Muhammed Magdy Abd El Razek; Dhaval P. Maghavani; Phetole Walter Mahasha; Narayan Bahadur Mahotra; Venkatesh Maled; Afshin Maleki; Shokofeh Maleki; Deborah Carvalho Malta; Ali Manafi; Farzad Manafi; Navid Manafi; Narendar Dawanu Manohar; Fariborz Mansour-Ghanaei; Borhan Mansouri; Mohammad Ali Mansournia; Chabila Christopher Mapoma; Dadi Marami; Laurie B. Marczak; Carlos Alberto Marrugo Arnedo; Francisco Rogerlândio Martins-Melo; Anthony Masaka; Benjamin Ballard Massenburg; Pallab K. Maulik; Benjamin K. Mayala; Mohsen Mazidi; Man Mohan Mehndiratta; Freshteh Mehri; Kala M. Mehta; Wahengbam Bigyananda Meitei; Fantahun Ayenew Mekonnen; Teferi Mekonnen; Gebrekiros Gebremichael Meles; Hagazi Gebre Meles; Addisu Melese; Walter Mendoza; Ritesh G. Menezes; Meresa Berwo Mengesha; George A. Mensah; Tuomo J. Meretoja; Tomasz Miazgowski; Neda Milevska Kostova; Ted R. Miller; Edward J. Mills; G.K. Mini; Seyed Mostafa Mir; Mohammad Miri; Hamed Mirjalali; Erkin M. Mirrakhimov; Hamed Mirzaei; Maryam Mirzaei; Roya Mirzaei; Mehdi Mirzaei-Alavijeh; Prasanna Mithra; Babak Moazen; Efat Mohamadi; Amjad Mohamadi-Bolbanabad; Karzan Abdulmuhsin Mohammad; Yousef Mohammad; Dara K. Mohammad; Aso Mohammad Darwesh; Naser Mohammad Gholi Mezerji; Abdollah Mohammadian-Hafshejani; Mousa Mohammadnia-Afrouzi; Milad Mohammadoo-Khorasani; Reza Mohammadpourhodki; Salahuddin Mohammed; Shafiu Mohammed; Jemal Abdu Mohammed; Ammas Siraj Mohammed; Farnam Mohebi; Amin Mokari; Ali H. Mokdad; Julio Cesar Montañez; Pablo A. Montero-Zamora; Yoshan Moodley; Maryam Moossavi; Ghobad Moradi; Masoud Moradi; Yousef Moradi; Mohammad Moradi-Joo; Maziar Moradi-Lakeh; Farhad Moradpour; Rahmatollah Moradzadeh; Paula Moraga; Shane Douglas Morrison; Abbas Mosapour; Jonathan F. Mosser; Simin Mouodi; Amin Mousavi Khaneghah; Dariush Mozaffarian; Ulrich Otto Mueller; Christopher J. L. Murray; G.V.S. Murthy; Kamarul Imran Musa; Ghulam Mustafa; Saravanan Muthupandian; Behnam Nabavizadeh; Mehdi Naderi; Girish N. Nadkarni; Ahamarshan Jayaraman Nagarajan; Mohsen Naghavi; Aliya Naheed; Gurudatta Naik; Farid Najafi; Jobert Richie Nansseu; K. M. Venkat Narayan; Bruno Ramos Nascimento; Vinod Nayak; Javad Nazari; Duduzile Edith Ndwandwe; Ionut Negoi; Ruxandra Irina Negoi; Josephine W. Ngunjiri; Cuong Tat Nguyen; Huong Lan Thi Nguyen; Dabere Nigatu; Yeshambel T. Nigatu; Rajan Nikbakhsh; Dina Nur Anggraini Ningrum; Chukwudi A. Nnaji; Vuong Minh Nong; Jean Jacques Noubiap; Christoph Nowak; Bogdan Oancea; Richard Ofori-Asenso; Onome Bright Oghenetega; In-Hwan Oh; Olanrewaju Oladimeji; Morteza Oladnabi; Andrew T. Olagunju; Tinuke O. Olagunju; Bolajoko Olubukunola Olusanya; Jacob Olusegun Olusanya; Mojisola Morenike Oluwasanu; Muktar Omer Omer; Obinna E. Onwujekwe; Kwaku Oppong Asante; Eyal Oren; Orish Ebere Orisakwe; Alberto Ortiz; Osayomwanbo Osarenotor; Aaron E. Osgood-Zimmerman; Mayowa Ojo Owolabi; Mahesh P. A; Jagadish Rao Padubidri; Keyvan Pakshir; Adrian Pana; Songhomitra Panda-Jonas; Hadi Parsian; Tahereh Pashaei; Deepak Kumar Pasupula; Sangram Kishor Patel; Ashish Pathak; Mona Pathak; Sanghamitra Pati; Ajay Patle; George C. Patton; Kebreab Paulos; Hamidreza Pazoki Toroudi; Veincent Christian Filipino Pepito; Norberto Perico; William A. Petri; Brandon V. Pickering; David M. Pigott; Majid Pirestani; Bakhtiar Piroozi; Meghdad Pirsaheb; Khem Narayan Pokhrel; Maarten J. Postma; Hadi Pourjafar; Farshad Pourmalek; Reza Pourmirza Kalhori; Akram Pourshams; Hossein Poustchi; Sergio I. Prada; Liliana Preotescu; Dimas Ria Angga Pribadi; Zahiruddin Quazi Syed; Mohammad Rabiee; Navid Rabiee; Amir Radfar; Alireza Rafiei; Fakher Rahim; Vafa Rahimi-Movaghar; Muhammad Aziz Rahman; Sajjad ur Rahman; Rajesh Kumar Rai; Ali Rajabpour-Sanati; Fatemeh Rajati; Kiana Ramezanzadeh; Saleem Muhammad Rana; Chhabi Lal Ranabhat; Sowmya J. Rao; Davide Rasella; Vahid Rashedi; Prateek Rastogi; Priya Rathi; Salman Rawaf; David Laith Rawaf; Lal Rawal; Sarah E. Ray; Giuseppe Remuzzi; Vishnu Renjith; Andre M. N. Renzaho; Serge Resnikoff; Nima Rezaei; Shahab Rezaeian; Mohammad Sadegh Rezai; Aziz Rezapour; Seyed Mohammad Riahi; Ana Isabel Ribeiro; Jennifer Rickard; Alina Rodriguez; Leonardo Roever; Elias Merdassa Roro; Gholamreza Roshandel; Ali Rostami; Enrico Rubagotti; Anas M. Saad; Seyedmohammad Saadatagah; Yogesh Damodar Sabde; Siamak Sabour; Ehsan Sadeghi; Masoumeh Sadeghi; Saeed Safari; Yahya Safari; Hamid Safarpour; Rajesh Sagar; Amirhossein Sahebkar; Mohammad Ali Sahraian; S. Mohammad Sajadi; Mohammad Reza Salahshoor; Nasir Salam; Farkhonde Salehi; Saleh Salehi Zahabi; Hosni Salem; Marwa R. Rashad Salem; Yahya Salimi; Hamideh Salimzadeh; Hossein Samadi Kafil; Evanson Zondani Sambala; Abdallah M. Samy; Itamar S. Santos; Bruno Piassi Sao Jose; Sivan Yegnanarayana Iyer Saraswathy; Abdur Razzaque Sarker; Benn Sartorius; Arash Sarveazad; Brijesh Sathian; Maheswar Satpathy; Sonia Saxena; Mehdi Sayyah; Alyssa N. Sbarra; Megan F. Schipp; Maria Inês Schmidt; Aletta Elisabeth Schutte; David C. Schwebel; Anbissa Muleta Senbeta; Subramanian Senthilkumaran; Seyedmojtaba Seyedmousavi; Faramarz Shaahmadi; Omid Shafaat; Saeed Shahabi; Masood Ali Shaikh; Ali S. Shalash; Mehran Shams-Beyranvand; Amir Shamshirian; Morteza Shamsizadeh; Mohammed Shannawaz; Kiomars Sharafi; Mehdi Sharif; Rajesh Sharma; Hatem Samir Shehata; Abbas Sheikhtaheri; Kenji Shibuya; Wondimeneh Shibabaw Shiferaw; Mika Shigematsu; Jae Il Shin; Rahman Shiri; Reza Shirkoohi; Ivy Shiue; Kerem Shuval; Soraya Siabani; Tariq J. Siddiqi; Inga Dora Sigfusdottir; Diego Augusto Santos Silva; Biagio Simonetti; Ambrish Singh; Pushpendra Singh; Virendra Singh; Jasvinder A. Singh; Pankaj Kumar Singh; Dhirendra Narain Sinha; Yitagesu Sintayehu; Malede Mequanent M. Sisay; Amin Soheili; Bija Soleymani; Farzaneh Soltani; Shahin Soltani; Joan B. Soriano; Muluken Bekele Sorrie; Sergey Soshnikov; Ireneous N. Soyiri; Adel Spotin; Chandrashekhar T. Sreeramareddy; Rajni Kant Kant Srivastava; Antonina Starodubova; Agus Sudaryanto; Mu’awiyyah Babale Sufiyan; Hafiz Ansar Rasul Suleria; Gerhard Sulo; Bruno F. Sunguya; Bryan L. Sykes; Rafael Tabarés-Seisdedos; Takahiro Tabuchi; Birkneh Tilahun Tadesse; Amir Taherkhani; Koku Sisay Tamirat; Segen Gebremeskel Tassew; Nuno Taveira; Berhane Fseha Teklehaimanot; Gebretsadkan Hintsa Tekulu; Mohamad-Hani Temsah; Abdullah Sulieman Terkawi; Zemenu Tadesse Tessema; Nihal Thomas; Mariya Vladimirovna Titova; Kenean Getaneh Tlaye; Hamid Reza Tohidinik; Marcello Tonelli; Marcos Roberto Tovani-Palone; Eugenio Traini; Khanh Bao Tran; Manjari Tripathi; Riaz Uddin; Irfan Ullah; Bhaskaran Unnikrishnan; Era Upadhyay; Ushotanefe Useh; Muhammad Shariq Usman; Olalekan A. Uthman; Marco Vacante; Masoud Vaezghasemi; Pascual R. Valdez; John VanderHeide; Elena Varavikova; Santosh Varughese; Tommi Juhani Vasankari; Yasser Vasseghian; Yousef Veisani; Srinivasaraghavan Venkatesh; Narayanaswamy Venketasubramanian; Madhur Verma; Simone Vidale; Francesco S. Violante; Vasily Vlassov; Sebastian Vollmer; Rade Vukovic; Yasir Waheed; Haidong Wang; Yafeng Wang; Yuan-Pang Wang; Girmay Teklay Weldesamuel; Andrea Werdecker; Taweewat Wiangkham; Kirsten E. Wiens; Tissa Wijeratne; Haileab Fekadu Wolde; Dawit Zewdu Wondafrash; Tewodros Eshete Wonde; Adam Belay Wondmieneh; Ai-Min Wu; Gelin Xu; Abbas Yadegar; Ali Yadollahpour; Seyed Hossein Yahyazadeh Jabbari; Tomohide Yamada; Yuichiro Yano; Sanni Yaya; Vahid Yazdi-Feyzabadi; Alex Yeshaneh; Yigizie Yeshaw; Yordanos Gizachew Yeshitila; Mekdes Tigistu Yilma; Paul Yip; Naohiro Yonemoto; Seok-Jun Yoon; Yoosik Youm; Mustafa Z. Younis; Zabihollah Yousefi; Hebat-Allah Salah A. Yousof; Chuanhua Yu; Hasan Yusefzadeh; Telma Zahirian Moghadam; Leila Zaki; Sojib Bin Zaman; Mohammad Zamani; Maryam Zamanian; Hamed Zandian; Hadi Zarafshan; Nejimu Biza Zepro; Taddese Alemu Zerfu; Taye Abuhay Zewale; Yunquan Zhang; Zhi-Jiang Zhang; Xiu-Ju Zhao; Sanjay Zodpey; Kamiar Zomorodian; Francis Bruno Zotor; Ashkan Afshin; Simon I. Hay
An amendment to this paper has been published and can be accessed via a link at the top of the paper. © 2020, The Author(s).
Biochar for pollutants bioremediation from soil and water ecosystem
(Elsevier, 2024) Amit K. Dash; Saloni Tripathy; A. Naveenkumar; Tanmaya K. Bhoi; Arpna Kumari; Divya; Ashish M. Latare; Tony Manoj Kumar Nandipamu; Virendra Singh; Md. Basit Raza; Anuj Saraswat; Jehangir Bhadha
Emerging contaminants (ECs) are chemical compounds that have potentially hazardous effects, but risks associated with their exposure have not been fully explored and are not yet subject to regulation. The fact that these ECs pollute both soil and water has recently raised significant concerns. Human and natural factors together make up the main sources of soil contamination. ECs are difficult to remove from soil and the aqueous system since they are retained in the environment for a very long period. Several techniques, including biodegradation, photocatalytic degradation, nanofiltration, membrane bioreactors, separation, enhanced chemical oxidation, and others, have been developed to remove ECs from the environment. One of the well-known innovations for tackling the issue of ECs is the application of in-situ biochar. Biochar application can significantly reduce the bioavailability of ECs that accumulate in soil and/or aqueous systems. It also has the added advantage of soil fertilization and climate change mitigation. In this chapter, emphasis has been given to the use of biochar for the remediation of ECs from the soil and aqueous system and factors affecting the efficiency of biochar as a bioremediation technique. © 2024 by Elsevier Inc. All rights reserved, including those for text and data mining, AI training, and similar technologies.
Bright-blue-emission nitrogen and phosphorus-doped carbon quantum dots as a promising nanoprobe for detection of Cr(vi) and ascorbic acid in pure aqueous solution and in living cells
(Royal Society of Chemistry, 2018) Vikas Kumar Singh; Virendra Singh; Pradeep Kumar Yadav; Subhash Chandra; Daraksha Bano; Vijay Kumar; Biplob Koch; Mahe Talat; Syed Hadi Hasan
Highly fluorescent nitrogen and phosphorus-doped carbon quantum dots (N,P-CQDs) were synthesized via a one-step hydrothermal method and fully characterized via various techniques such as TEM, DLS, FT-IR, P-XRD and XPS analysis. The as-synthesized N,P-CQDs showed excellent optical properties and exhibited bright blue colour under UV-light with CIE coordinate (0.20, 0.22) along with a high quantum yield of 73%, due to which they could act as on-off fluorescent nanoprobes for the selective and sensitive detection of highly toxic Cr(vi) below its permissible limit via the inner filter effect (IFE) and static quenching mechanism. In addition, Cr(vi) could be reduced to lower valent chromium species. Therefore, the N,P-CQDs + Cr(vi) system further acted as a selective off-on sensor for reductant ascorbic acid (AA) because it reduced Cr(vi) to Cr(iii) species, resulting in the elimination of IFE and recovery of fluorescence of N,P-CQDs. Notably, this system possesses excellent biocompatibility and negligible cytotoxicity; therefore, it can be potentially applied for fluorescence imaging of intracellular Cr(vi) and ascorbic acid (AA) in living cells and complex biological systems. © 2018 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.
Chitosan nanoplatform for the co-delivery of palbociclib and ultra-small magnesium nanoclusters: dual receptor targeting, therapy and imaging
(Ivyspring International Publisher, 2024) Abhishesh Kumar Mehata; Virendra Singh; Vikas; Prachi Srivastava; Biplob Koch; Manoj Kumar; Madaswamy S. Muthu
Theranostic nanoparticles have gained significant attention in cancer diagnosis and therapy. In this study, estrone (ES) and folic acid (FA) functionalized single and dual receptor targeted theranostic chitosan nanoparticles were developed for breast cancer imaging and therapy. These nanoparticles (NPs) were loaded with palbociclib (PB) and ultra-small magnesium nanoclusters (UMN). The developed nontargeted theranostic NPs (PB-UMN-CS-NPs), estrogen receptor targeted theranostic NPs (PB-UMN-CS-ES-NPs), folate receptor targeted theranostic NPs (PB-UMN-CS-FA-NPs), and dual targeted theranostic NPs (PB-UMN-CS-ES-FA-NPs) have particle sizes of 178.4 ± 1.21 nm, 181.6± 1.35 nm, 185.1± 1.33 nm, and 198.2± 1.43 nm with surface charges of +19.02± 0.382 mV, +13.89±0.410 mV, +16.72±0.527 mV and +15.23±0.377 mV, respectively. Cytotoxicity studies on estrogen receptor (ER) and folate receptor (FR) expressing breast cancer cells revealed that dual-targeted theranostic NPs (PB-UMN-CS-FA-ES-NPs) were more effective, inhibiting cell growth by 54.17 and 42.23 times in MCF-7 and T-47D cells compared to free PB, respectively. Additionally, developed NPs were capable of inhibiting the cell cycle progression of MCF-7 cells from the G1 phase to the S phase more efficiently compared to free PB. Ultrasound and photoacoustic (USG/PA) imaging demonstrated that dual targeted theranostic NPs were capable of effectively reducing hypoxic tumor volume and significantly suppressing tumor vascularity compared to free PB, nontargeted, FR targeted and ER targeted NPs. Moreover, in vivo optical imaging demonstrated tumor specific accumulation of the dual-targeted theranostic NPs. Furthermore, in vitro hemocompatibility and histopathological studies confirmed the biocompatibility of developed nanoformulations. © The author(s).
Chitosan-g-estrone Nanoparticles of Palbociclib Vanished Hypoxic Breast Tumor after Targeted Delivery: Development and Ultrasound/Photoacoustic Imaging
(American Chemical Society, 2023) Abhishesh Kumar Mehata; Virendra Singh; None Vikas; Nitesh Singh; Abhijit Mandal; Debabrata Dash; Biplob Koch; Madaswamy S. Muthu
Breast cancer is the leading cause of death among women globally. Approximately 80% of all breast cancers diagnosed are overexpressed with estrogen receptors (ERs). In this study, we have developed an estrone (Egen)-grafted chitosan-based polymeric nanocarrier for the targeted delivery of palbociclib (PLB) to breast cancer. The nanoparticles (NPs) were prepared by solvent evaporation using the ionic gelation method and characterized for particle size, zeta potential, polydispersity, surface morphology, surface chemistry, drug entrapment efficiency, cytotoxicity assay, cellular uptake, and apoptosis study. The developed PLB-CS NPs and PLB-CS-g-Egen NPs had a particle size of 116.3 ± 1.53 nm and 141.6 ± 1.97 nm, respectively. The zeta potential of PLB-CS NPs and PLB-CS-g-Egen NPs was found to be 18.70 ± 0.416 mV and 12.45 ± 0.574 mV, respectively. The morphological analysis demonstrated that all NPs were spherical in shape and had a smooth surface. An in vitro cytotoxicity assay was performed in estrogen receptor (ER)-expressing MCF7 cells and T47D cells, which suggested that targeted NPs were 57.34- and 30.32-fold more cytotoxic compared to the pure PLB, respectively. Additionally, cell cycle analysis confirmed that cell cycle progression from the G1 into S phase was blocked more efficiently by targeted NPs compared to nontargeted NPs and PLB in MCF7 cells. In vivo pharmacokinetic studies demonstrated that entrapment of the PLB in the NPs improved the half-life and bioavailability by ∼2-3-fold. Further, ultrasound and photoacoustic imaging of DMBA induced breast cancer in the Sprague-Dawley (SD) rat showed that targeted NPs completely vanished breast tumor, reduced hypoxic tumor volume, and suppressed tumor angiogenesis more efficiently compared to the nontargeted NPs and free PLB. Further, in vitro hemocompatibility and histopathology studies suggested that NPs were biocompatible and safe for clinical use. © 2023 American Chemical Society.
Comparative analysis of resource use efficiency in menthol- mint cultivation on different farm size groups in India
(IndianJournals.com, 2017) Harshika Choudhary; Virendra Singh; P.S. Badal; Rajani Osti
The Mentha arvensis (menthol mint) is an important essential oil bearing plant and widely used in food, flavour, pharmaceutical and cosmetic industries. Amongst the aromatic crops grown in India mentha is an important crop. India has the largest production, consumption and export of mentha. The favourable climatic conditions of Rampur offer enormous potential for the development of mentha, but the low crop yield and high cost of cultivation and poor resource-use efficiency discourage the growers to give boost to its cultivation. There is need to tape this untapped potential so that production will increase and growers will be benef itted. The present study was conducted in Rampur district of Uttar Pradesh with the objective to find out resource use efficiency of farmers in mentha cultivation. Multi-stage sampling technique was used to select blocks, villages and the respondents from the four villages of two blocks of Rampur district. Cobb-Douglas production function was employed to estimate the resource use efficiency. The variables seed on small farms, fertilizers on medium and irrigation and human labour on large farms were found to be significantly influencing the mentha yield, while the variable distillation facility was found to be signif icantly influencing the mentha yield on all farms except large ones. © 2017, IndianJournals.com. All rights reserved.
Comparative Study of Sonodynamic and Photoactivated Cancer Therapies with Re(I)-Tricarbonyl Complexes Comprising Phenanthroline Ligands
(American Chemical Society, 2024) Rajesh Kushwaha; Virendra Singh; Silda Peters; Ashish Kumar Yadav; Tumpa Sadhukhan; Biplob Koch; Samya Banerjee
Herein, we have compared the effectivity of light-based photoactivated cancer therapy and ultrasound-based sonodynamic therapy with Re(I)-tricarbonyl complexes (Re1-Re3) against cancer cells. The observed photophysical and TD-DFT calculations indicated the potential of Re1-Re3 to act as good anticancer agents under visible light/ultrasound exposure. Re1 did not display any dark- or light- or ultrasound-triggered anticancer activity. However, Re2 and Re3 displayed concentration-dependent anticancer activity upon light and ultrasound exposure. Interestingly, Re3 produced 1O2 and OH• on light/ultrasound exposure. Moreover, Re3 induced NADH photo-oxidation in PBS and produced H2O2. To the best of our knowledge, NADH photo-oxidation has been achieved here with the Re(I) complex for the first time in PBS. Additionally, Re3 released CO upon light/ultrasound exposure. The cell death mechanism revealed that Re3 produced an apoptotic cell death response in HeLa cells via ROS generation. Interestingly, Re3 showed slightly better anticancer activity under light exposure compared to ultrasound exposure. © 2024 American Chemical Society
Density Functional Theory-Guided Photo-Triggered Anticancer Activity of Curcumin-Based Zinc(II) Complexes
(American Chemical Society, 2023) Rajesh Kushwaha; Virendra Singh; Silda Peters; Ashish K. Yadav; Dependu Dolui; Sukanta Saha; Sujit Sarkar; Arnab Dutta; Biplob Koch; Tumpa Sadhukhan; Samya Banerjee
Photodynamic therapy (PDT) has evolved as a new therapeutic modality for cancer treatment with fewer side effects and drug resistance. Curcumin exhibits PDT activity, but its low bioavailability restricts its clinical application. Here, the bioavailability of curcumin was increased by its complex formation with the Zn(II) center. For a structure-activity relationship study, Zn(II)-based complexes (1-3) comprising N^N-based ligands (2,2′-bipyridine in 1 and 2 or 1,10-phenanthroline in 3) and O^O-based ligands (acetylacetone in 1, monoanionic curcumin in 2 and 3) were synthesized and thoroughly characterized. The X-ray structure of the control complex, 1, indicated a square pyramidal shape of the molecules. Photophysical and TD-DFT studies indicated the potential of 2 and 3 as good visible light type-II photosensitizers for PDT. Guided by the TD-DFT studies, the low-energy visible light-triggered singlet oxygen (1O2) generation efficacy of 2 and 3 was explored in solution and in cancer cells. As predicted by the TD-DFT calculations, these complexes produced 1O2 efficiently in the cytosol of MCF-7 cancer cells and ultimately displayed excellent apoptotic anticancer activity in the presence of light. Moreover, the molecular docking investigation showed that complexes 2 and 3 have very good binding affinities with caspase-9 and p-53 proteins and could activate them for cellular apoptosis. Further molecular dynamics simulations confirmed the stability of 3 in the caspase-9 protein binding site. © 2023 American Chemical Society.
Development of chitosan towards the self-healing and mechanically stronger biocompatible hydrogel
(Elsevier B.V., 2022) Shere Afgan; Paramjeet Yadav; Sheetal Jaiswal; Krishtan Pal; Rajesh Kumar; Virendra Singh; Biplob koch
Nontoxic, self-healing and biocompatible Chitosan grafted poly (maleic anhydride) based hydrogel (CSHG) have been developed by using Chitosan (CS) and maleic anhydride (MAH) having reasonable mechanical strength with biocompatibility. The self-healing arises due to the presence of free primary amine group and carboxyl group in grafted chitosan either dynamic imine covalent interaction or non-covalent (H-bonding) interactions. In addition to this, the hydrogel showed tremendous swelling at various pH values viz. - 2, 7 and 9, and morphological study reveals the porous nature of the synthesized CSHG hydrogel. The cell viability (MTT) of CS and CSHG was performed on MCF-7 (breast cancer cell line), and phase contrast (cell imaging) of CS and CSHG was taken at 1:5, 1:10, 1:50 and 1:100 ratios in both cases which do not induce any significant changes in cellular morphology thus makes it biocompatible and can be used as biological applications. © 2022 Indian Chemical Society
Erratum: Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017 (The Lancet (2018) 392(10159) (1736–1788)(S0140673618322037)(10.1016/S0140-6736(18)32203-7))
(Lancet Publishing Group, 2018) Gregory A. Roth; Degu Abate; Kalkidan Hassen Abate; Solomon M. Abay; Cristiana Abbafati; Nooshin Abbasi; Hedayat Abbastabar; Foad Abd-Allah; Jemal Abdela; Ahmed Abdelalim; Ibrahim Abdollahpour; Rizwan Suliankatchi Abdulkader; Haftom Temesgen Abebe; Molla Abebe; Zegeye Abebe; Ayenew Negesse Abejie; Semaw F. Abera; Olifan Zewdie Abil; Haftom Niguse Abraha; Aklilu Roba Abrham; Laith Jamal Abu-Raddad; Manfred Mario Kokou Accrombessi; Dilaram Acharya; Abdu A. Adamu; Oladimeji M. Adebayo; Rufus Adesoji Adedoyin; Victor Adekanmbi; Olatunji O. Adetokunboh; Beyene Meressa Adhena; Mina G. Adib; Amha Admasie; Ashkan Afshin; Gina Agarwal; Kareha M. Agesa; Anurag Agrawal; Sutapa Agrawal; Alireza Ahmadi; Mehdi Ahmadi; Muktar Beshir Ahmed; Sayem Ahmed; Amani Nidhal Aichour; Ibtihel Aichour; Miloud Taki Eddine Aichour; Mohammad Esmaeil Akbari; Rufus Olusola Akinyemi; Nadia Akseer; Ziyad Al-Aly; Ayman Al-Eyadhy; Rajaa M. Al-Raddadi; Fares Alahdab; Khurshid Alam; Tahiya Alam; Animut Alebel; Kefyalew Addis Alene; Mehran Alijanzadeh; Reza Alizadeh-Navaei; Syed Mohamed Aljunid; Ala'a Alkerwi; Francois Alla; Peter Allebeck; Jordi Alonso; Khalid Altirkawi; Nelson Alvis-Guzman; Azmeraw T. Amare; Leopold N. Aminde; Erfan Amini; Walid Ammar; Yaw Ampem Amoako; Nahla Hamed Anber; Catalina Liliana Andrei; Sofia Androudi; Megbaru Debalkie Animut; Mina Anjomshoa; Hossein Ansari; Mustafa Geleto Ansha; Carl Abelardo T. Antonio; Palwasha Anwari; Olatunde Aremu; Johan Arnlov; Amit Arora; Monika Arora; Al Artaman; Krishna K. Aryal; Hamid Asayesh; Ephrem Tsegay Asfaw; Zerihun Ataro; Suleman Atique; Sachin R. Atre; Marcel Ausloos; Euripide F.G.A. Avokpaho; Ashish Awasthi; Beatriz Paulina Ayala Quintanilla; Yohanes Ayele; Rakesh Ayer; Peter S. Azzopardi; Arefeh Babazadeh; Umar Bacha; Hamid Badali; Alaa Badawi; Ayele Geleto Bali; Katherine E. Ballesteros; Maciej Banach; Kajori Banerjee; Marlena S. Bannick; Joseph Adel Mattar Banoub; Miguel A. Barboza; Suzanne Lyn Barker-Collo; Till Winfried Barnighausen; Simon Barquera; Lope H. Barrero; Quique Bassat; Sanjay Basu; Bernhard T. Baune; Habtamu Wondifraw Baynes; Shahrzad Bazargan-Hejazi; Neeraj Bedi; Ettore Beghi; Masoud Behzadifar; Meysam Behzadifar; Yannick Bejot; Bayu Begashaw Bekele; Abate Bekele Belachew; Ezra Belay; Yihalem Abebe Belay; Michelle L. Bell; Aminu K. Bello; Derrick A. Bennett; Isabela M. Bensenor; Adam E. Berman; Eduardo Bernabe; Robert S. Bernstein; Gregory J. Bertolacci; Mircea Beuran; Tina Beyranvand; Ashish Bhalla; Suraj Bhattarai; Soumyadeeep Bhaumik; Zulfiqar A. Bhutta; Belete Biadgo; Molly H. Biehl; Ali Bijani; Boris Bikbov; Ver Bilano; Nigus Bililign; Muhammad Shahdaat Bin Sayeed; Donal Bisanzio; Tuhin Biswas; Brigette F. Blacker; Berrak Bora Basara; Rohan Borschmann; Cristina Bosetti; Kayvan Bozorgmehr; Oliver J. Brady; Luisa C. Brant; Carol Brayne; Alexandra Brazinova; Nicholas J.K. Breitborde; Hermann Brenner; Paul Svitil Briant; Gabrielle Britton; Traolach Brugha; Reinhard Busse; Zahid A. Butt; Charlton S.K.H. Callender; Ismael R. Campos-Nonato; Julio Cesar Campuzano Rincon; Jorge Cano; Mate Car; Rosario Cardenas; Giulia Carreras; Juan J. Carrero; Austin Carter; Felix Carvalho; Carlos A. Castaneda-Orjuela; Jacqueline Castillo Rivas; Chris D. Castle; Clara Castro; Franz Castro; Ferran Catala-Lopez; Ester Cerin; Yazan Chaiah; Jung-Chen Chang; Fiona J. Charlson; Pankaj Chaturvedi; Peggy Pei-Chia Chiang; Odgerel Chimed-Ochir; Vesper Hichilombwe Chisumpa; Abdulaal Chitheer; Rajiv Chowdhury; Hanne Christensen; Devasahayam J. Christopher; Sheng-Chia Chung; Flavia M. Cicuttini; Liliana G. Ciobanu; Massimo Cirillo; Aaron J. Cohen; Leslie Trumbull Cooper; Paolo Angelo Cortesi; Monica Cortinovis; Ewerton Cousin; Benjamin C. Cowie; Michael H. Criqui; Elizabeth A. Cromwell; Christopher Stephen Crowe; John A. Crump; Matthew Cunningham; Alemneh Kabeta Daba; Abel Fekadu Dadi; Lalit Dandona; Rakhi Dandona; Anh Kim Dang; Paul I. Dargan; Ahmad Daryani; Siddharth K. Das; Rajat Das Gupta; Jose Das Neves; Tamirat Tesfaye Dasa; Aditya Prasad Dash; Adrian C. Davis; Nicole Davis Weaver; Dragos Virgil Davitoiu; Kairat Davletov; Fernando Pio De La Hoz; Jan-Walter De Neve; Meaza Girma Degefa; Louisa Degenhardt; Tizta T. Degfie; Selina Deiparine; Gebre Teklemariam Demoz; Balem Betsu Demtsu; Edgar Denova-Gutierrez; Kebede Deribe; Nikolaos Dervenis; Don C. Des Jarlais; Getenet Ayalew Dessie; Subhojit Dey; Samath D. Dharmaratne; Daniel Dicker; Mesfin Tadese Dinberu; Eric L. Ding; M. Ashworth Dirac; Shirin Djalalinia; Klara Dokova; David Teye Doku; Christl A. Donnelly; E. Ray Dorsey; Pratik P. Doshi; Dirk Douwes-Schultz; Kerrie E. Doyle; Tim R. Driscoll; Manisha Dubey; Eleonora Dubljanin; Eyasu Ejeta Duken; Bruce B. Duncan; Andre R. Duraes; Hedyeh Ebrahimi; Soheil Ebrahimpour; Dumessa Edessa; David Edvardsson; Anne Elise Eggen; Charbel El Bcheraoui; Maysaa El Sayed Zaki; Ziad El-Khatib; Hajer Elkout; Christian Lycke Ellingsen; Matthias Endres; Aman Yesuf Endries; Benjamin Er; Holly E. Erskine; Babak Eshrati; Sharareh Eskandarieh; Reza Esmaeili; Alireza Esteghamati; Mahdi Fakhar; Hamed Fakhim; Mahbobeh Faramarzi; Mohammad Fareed; Farzaneh Farhadi; Carla Sofia Esá Farinha; Andre Faro; Maryam S. Farvid; Farshad Farzadfar; Mohammad Hosein Farzaei; Valery L. Feigin; Andrea B. Feigl; Netsanet Fentahun; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; Joao C. Fernandes; Alize J. Ferrari; Garumma Tolu Feyissa; Irina Filip; Samuel Finegold; Florian Fischer; Christina Fitzmaurice; Nataliya A. Foigt; Kyle J. Foreman; Carla Fornari; Tahvi D. Frank; Takeshi Fukumoto; John E. Fuller; Nancy Fullman; Thomas Furst; Joao M. Furtado; Neal D. Futran; Silvano Gallus; Alberto L. Garcia-Basteiro; Miguel A. Garcia-Gordillo; William M. Gardner; Abadi Kahsu Gebre; Tsegaye Tewelde Gebrehiwot; Amanuel Tesfay Gebremedhin; Bereket Gebremichael; Teklu Gebrehiwo Gebremichael; Tilayie Feto Gelano; Johanna M. Geleijnse; Ricard Genova-Maleras; Yilma Chisha Dea Geramo; Peter W. Gething; Kebede Embaye Gezae; Mohammad Rasoul Ghadami; Reza Ghadimi; Khalil Ghasemi Falavarjani; Maryam Ghasemi-Kasman; Mamata Ghimire; Katherine B. Gibney; Paramjit Singh Gill; Tiffany K. Gill; Richard F. Gillum; Ibrahim Abdelmageed Ginawi; Maurice Giroud; Giorgia Giussani; Shifalika Goenka; Ellen M. Goldberg; Srinivas Goli; Hector Gomez-Dantes; Philimon N. Gona; Sameer Vali Gopalani; Taren M. Gorman; Atsushi Goto; Alessandra C. Goulart; Elena V. Gnedovskaya; Ayman Grada; Giuseppe Grosso; Harish Chander Gugnani; Andre Luiz Sena Guimaraes; Yuming Guo; Prakash C. Gupta; Rahul Gupta; Rajeev Gupta; Tanush Gupta; Reyna Alma Gutierrez; Bishal Gyawali; Juanita A. Haagsma; Nima Hafezi-Nejad; Tekleberhan B. Hagos; Tewodros Tesfa Hailegiyorgis; Gessessew Bugssa Hailu; Arvin Haj-Mirzaian; Arya Haj-Mirzaian; Randah R. Hamadeh; Samer Hamidi; Alexis J. Handal; Graeme J. Hankey; Hilda L. Harb; Sivadasanpillai Harikrishnan; Josep Maria Haro; Mehedi Hasan; Hadi Hassankhani; Hamid Yimam Hassen; Rasmus Havmoeller; Roderick J. Hay; Simon I. Hay; Yihua He; Akbar Hedayatizadeh-Omran; Mohamed I. Hegazy; Behzad Heibati; Mohsen Heidari; Delia Hendrie; Andualem Henok; Nathaniel J. Henry; Claudiu Herteliu; Fatemeh Heydarpour; Pouria Heydarpour; Sousan Heydarpour; Desalegn Tsegaw Hibstu; Hans W. Hoek; Michael K. Hole; Enayatollah Homaie Rad; Praveen Hoogar; H. Dean Hosgood; Seyed Mostafa Hosseini; Mehdi Hosseinzadeh; Mihaela Hostiuc; Sorin Hostiuc; Peter J. Hotez; Damian G. Hoy; Thomas Hsiao; Guoqing Hu; John J. 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GBD 2017 Causes of Death Collaborators. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018; 392: 1736–88—The bottom row in figure 7 was cut off. This correction has been made to the online version as of Nov 9, 2018, and has been made to the printed Article. © 2018 Elsevier Ltd
Erratum: Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 (The Lancet (2018) 392(10159) (1923–1994), (S0140673618322256), (10.1016/S0140-6736(18)32225-6))
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Background The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk–outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved methods, new risks and risk–outcome pairs, and new data on risk exposure levels and risk–outcome associations. Methods We used the CRA framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs), by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or groups of risks from 1990 to 2017. This study included 476 risk–outcome pairs that met the GBD study criteria for convincing or probable evidence of causation. We extracted relative risk and exposure estimates from 46 749 randomised controlled trials, cohort studies, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. Using the counterfactual scenario of theoretical minimum risk exposure level (TMREL), we estimated the portion of deaths and DALYs that could be attributed to a given risk. We explored the relationship between development and risk exposure by modelling the relationship between the Socio-demographic Index (SDI) and risk-weighted exposure prevalence and estimated expected levels of exposure and risk-attributable burden by SDI. Finally, we explored temporal changes in risk-attributable DALYs by decomposing those changes into six main component drivers of change as follows: (1) population growth; (2) changes in population age structures; (3) changes in exposure to environmental and occupational risks; (4) changes in exposure to behavioural risks; (5) changes in exposure to metabolic risks; and (6) changes due to all other factors, approximated as the risk-deleted death and DALY rates, where the risk-deleted rate is the rate that would be observed had we reduced the exposure levels to the TMREL for all risk factors included in GBD 2017. Findings In 2017, 34·1 million (95% uncertainty interval [UI] 33·3–35·0) deaths and 1·21 billion (1·14–1·28) DALYs were attributable to GBD risk factors. Globally, 61·0% (59·6–62·4) of deaths and 48·3% (46·3–50·2) of DALYs were attributed to the GBD 2017 risk factors. When ranked by risk-attributable DALYs, high systolic blood pressure (SBP) was the leading risk factor, accounting for 10·4 million (9·39–11·5) deaths and 218 million (198–237) DALYs, followed by smoking (7·10 million [6·83–7·37] deaths and 182 million [173–193] DALYs), high fasting plasma glucose (6·53 million [5·23–8·23] deaths and 171 million [144–201] DALYs), high body-mass index (BMI; 4·72 million [2·99–6·70] deaths and 148 million [98·6–202] DALYs), and short gestation for birthweight (1·43 million [1·36–1·51] deaths and 139 million [131–147] DALYs). In total, risk-attributable DALYs declined by 4·9% (3·3–6·5) between 2007 and 2017. In the absence of demographic changes (ie, population growth and ageing), changes in risk exposure and risk-deleted DALYs would have led to a 23·5% decline in DALYs during that period. Conversely, in the absence of changes in risk exposure and risk-deleted DALYs, demographic changes would have led to an 18·6% increase in DALYs during that period. The ratios of observed risk exposure levels to exposure levels expected based on SDI (O/E ratios) increased globally for unsafe drinking water and household air pollution between 1990 and 2017. This result suggests that development is occurring more rapidly than are changes in the underlying risk structure in a population. Conversely, nearly universal declines in O/E ratios for smoking and alcohol use indicate that, for a given SDI, exposure to these risks is declining. In 2017, the leading Level 4 risk factor for age-standardised DALY rates was high SBP in four super-regions: central Europe, eastern Europe, and central Asia; north Africa and Middle East; south Asia; and southeast Asia, east Asia, and Oceania. The leading risk factor in the high-income super-region was smoking, in Latin America and Caribbean was high BMI, and in sub-Saharan Africa was unsafe sex. O/E ratios for unsafe sex in sub-Saharan Africa were notably high, and those for alcohol use in north Africa and the Middle East were notably low. Interpretation By quantifying levels and trends in exposures to risk factors and the resulting disease burden, this assessment offers insight into where past policy and programme efforts might have been successful and highlights current priorities for public health action. Decreases in behavioural, environmental, and occupational risks have largely offset the effects of population growth and ageing, in relation to trends in absolute burden. Conversely, the combination of increasing metabolic risks and population ageing will probably continue to drive the increasing trends in non-communicable diseases at the global level, which presents both a public health challenge and opportunity. We see considerable spatiotemporal heterogeneity in levels of risk exposure and risk-attributable burden. Although levels of development underlie some of this heterogeneity, O/E ratios show risks for which countries are overperforming or underperforming relative to their level of development. As such, these ratios provide a benchmarking tool to help to focus local decision making. Our findings reinforce the importance of both risk exposure monitoring and epidemiological research to assess causal connections between risks and health outcomes, and they highlight the usefulness of the GBD study in synthesising data to draw comprehensive and robust conclusions that help to inform good policy and strategic health planning. Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
Erratum: Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015 (The Lancet (2016) 388(10053) (1725–1774)(S0140673616315756)(10.1016/S0140-6736(16)31575-6))
(Lancet Publishing Group, 2017) Haidong Wang; Zulfiqar A Bhutta; Matthew M Coates; Megan Coggeshall; Lalit Dandona; Khassoum Diallo; Elisabeth Barboza Franca; Maya Fraser; Nancy Fullman; Peter W Gething; Simon I Hay; Yohannes Kinfu; Maaya Kita; Xie Rachel Kulikoff; Heidi J Larson; Juan Liang; Xiaofeng Liang; Stephen S Lim; Margaret Lind; Alan D Lopez; Rafael Lozano; George A Mensah; Joseph B Mikesell; Ali H Mokdad; Meghan D Mooney; Mohsen Naghavi; Grant Nguyen; Ivo Rakovac; Joshua A Salomon; Naris Silpakit; Amber Sligar; Reed J D Sorensen; Theo Vos; Jun Zhu; Amanuel Alemu Abajobir; Kalkidan Hassen Abate; Kaja M Abbas; Foad Abd-Allah; Abdishakur M Abdulle; Semaw Ferede Abera; Victor Aboyans; Biju Abraham; Ibrahim Abubakar; Laith J Abu-Raddad; Niveen M E Abu-Rmeileh; Gebre Yitayih Abyu; Tom Achoki; Akindele Olupelumi Adebiyi; Isaac Akinkunmi Adedeji; Ademola Lukman Adelekan; Arsène Kouablan Adou; Arnav Agarwal; Oluremi N Ajala; Tomi F Akinyemiju; Nadia Akseer; Khurshid Alam; Noore K M Alam; Deena Alasfoor; Robert William Aldridge; Miguel Angel Alegretti; Zewdie Aderaw Alemu; Raghib Ali; Ala’a Alkerwi; François Alla; Rajaa Al-Raddadi; Ubai Alsharif; Khalid A Altirkawi; Elena Alvarez Martin; Nelson Alvis-Guzman; Azmeraw T Amare; Alemayehu Amberbir; Adeladza Kofi Amegah; Emmanuel A Ameh; Walid Ammar; Stephen Marc Amrock; Hjalte H Andersen; Gregory M Anderson; Carl Abelardo T Antonio; Johan Ärnlöv; Al Artaman; Hamid Asayesh; Rana Jawad Asghar; Reza Assadi; Suleman Atique; Euripide Frinel G Arthur Avokpaho; Ashish Awasthi; Beatriz Paulina Ayala Quintanilla; Umar Bacha; Alaa Badawi; Kalpana Balakrishnan; Amitava Banerjee; Bolanle F Banigbe; Aleksandra Barac; Ryan M Barber; Suzanne L Barker-Collo; Till Bärnighausen; Lope H Barrero; Tigist Assefa Bayou; Yibeltal Tebekaw Bayou; Shahrzad Bazargan-Hejazi; Justin Beardsley; Neeraj Bedi; Tolesa Bekele; Michelle L Bell; Aminu K Bello; Derrick A Bennett; Isabela M Bensenor; Adugnaw Berhane; Eduardo Bernabé; Balem Demtsu Betsu; Addisu Shunu Beyene; Samir Bhatt; Sibhatu Biadgilign; Boris Bikbov; Sait Mentes Birlik; Donal Bisanzio; Espen Bjertness; Jed D Blore; Rupert R A Bourne; Michael Brainin; Alexandra Brazinova; Nicholas J K Breitborde; Alexandria Brown; Geoffrey Colin Buckle; Michael Burch; Zahid A Butt; Ismael Ricardo Campos-Nonato; Julio Cesar Campuzano; Rosario Cárdenas; David O Carpenter; Juan Jesus Carrero; Austin Carter; Daniel C Casey; Carlos A Castañeda-Orjuela; Jacqueline Castillo Rivas; Ruben Estanislao Castro; Ferrán Catalá-López; Kelly Cercy; Hsing-Yi Chang; Jung-Chen Chang; Chioma Ezinne Chibueze; Vesper Hichilombwe Chisumpa; Jee-Young Jasmine Choi; Rajiv Chowdhury; Devasahayam Jesudas Christopher; Liliana G Ciobanu; Samantha M Colquhoun; Cyrus Cooper; Leslie Cornaby; Solomon Abrha Damtew; Hadi Danawi; Rakhi Dandona; José Das Neves; Adrian C Davis; Pieter de Jager; Diego De Leo; Louisa Degenhardt; Kebede Deribe; Amare Deribew; Don C Des Jarlais; Gabrielle A Deveber; Samath D Dharmaratne; Preet K Dhillon; Eric L Ding; Pratik Pinal Doshi; Kerrie E Doyle; Leilei Duan; Manisha Dubey; Hedyeh Ebrahimi; Christian Lycke Ellingsen; Iqbal Elyazar; Aman Yesuf Endries; Sergey Petrovich Ermakov; Babak Eshrati; Alireza Esteghamati; Emerito Jose Aquino Faraon; Talha A Farid; Carla Sofia E Sa Farinha; André Faro; Maryam S Farvid; Farshad Farzadfar; Seyed-Mohammad Fereshtehnejad; Joao C Fernandes; Florian Fischer; Joseph R A Fitchett; Nataliya Foigt; Richard C Franklin; Joseph Friedman; Thomas Fürst; Ketevan Gambashidze; Amiran Gamkrelidze; Parthasarathi Ganguly; Teshome Gebre; Tsegaye Tewelde Gebrehiwot; Amanuel Tesfay Gebremedhin; Alemseged Aregay Gebru; Johanna M Geleijnse; Bradford D Gessner; Ibrahim Abdelmageem Mohamed Ginawi; Ababi Zergaw Giref; Melkamu Dedefo Gishu; Hector Gomez-Dantes; Philimon Gona; Amador Goodridge; Sameer Vali Gopalani; Atsushi Goto; Hebe N Gouda; Harish Chander Gugnani; Yuming Guo; Rahul Gupta; Rajeev Gupta; Vipin Gupta; Bishal Gyawali; Juanita A Haagsma; Nima Hafezi-Nejad; Demewoz Haile; Alemayehu Desalegne Hailu; Gessessew Bugssa Hailu; Randah Ribhi Hamadeh; Samer Hamidi; Jamie Hancock; Alexis J Handal; Graeme J Hankey; Hilda L Harb; Sivadasanpillai Harikrishnan; Kimani M Harun; Rasmus Havmoeller; Roderick J Hay; Ileana Beatriz Heredia-Pi; Hans W Hoek; Masako Horino; Nobuyuki Horita; H. Dean Hosgood; Peter J Hotez; Damian G Hoy; Mohamed Hsairi; Guoqing Hu; Cheng Huang; John J Huang; Hsiang Huang; Laetitia Huiart; Chantal Huynh; Kim Moesgaard Iburg; Bulat T Idrisov; Kaire Innos; Kathryn H Jacobsen; Nader Jahanmehr; Mehdi Javanbakht; Achala Upendra Jayatilleke; Sun Ha Jee; Panniyammakal Jeemon; Vivekanand Jha; Guohong Jiang; Ying Jiang; Tariku Jibat; Ye Jin; Jost B Jonas; Zubair Kabir; Yogeshwar Kalkonde; Ritul Kamal; Haidong Kan; Gagandeep Kang; André Karch; Corine Kakizi Karema; Amir Kasaeian; Anil Kaul; Norito Kawakami; Jeanne Françoise Kayibanda; Konstantin Kazanjan; Peter Njenga Keiyoro; Andrew Haddon Kemp; Andre Pascal Kengne; Andre Keren; Maia Kereselidze; Chandrasekharan Nair Kesavachandran; Yousef Saleh Khader; Ibrahim A Khalil; Abdur Rahman Khan; Ejaz Ahmad Khan; Young-Ho Khang; Irma Khonelidze; Jagdish Khubchandani; Cho-Il Kim; Daniel Kim; Yun Jin Kim; Niranjan Kissoon; Miia Kivipelto; Luke D Knibbs; Yoshihiro Kokubo; Soewarta Kosen; Parvaiz A Koul; Ai Koyanagi; Barthelemy Kuate Defo; Burcu Kucuk Bicer; Andreas A Kudom; G. Anil Kumar; Michael J Kutz; Hmwe H Kyu; Dharmesh Kumar Lal; Ratilal Lalloo; Hilton Lam; Jennifer O Lam; Van C Lansingh; Anders Larsson; James Leigh; Ricky Leung; Yichong Li; Yongmei Li; M Patrice Lindsay; Patrick Y Liu; Shiwei Liu; Belinda K Lloyd; Warren D Lo; Giancarlo Logroscino; Nicola Low; Raimundas Lunevicius; Ronan A Lyons; Stefan Ma; Hassan Magdy Abd El Razek; Mohammed Magdy Abd El Razek; Mahdi Mahdavi; Marek Majdan; Azeem Majeed; Reza Malekzadeh; Chabila C Mapoma; Wagner Marcenes; Jose Martinez-Raga; Melvin Barrientos Marzan; Felix Masiye; John J McGrath; Peter A Meaney; Alem Mehari; Man Mohan Mehndiratta; Alemayehu B Mekonnen; Yohannes Adama Melaku; Peter Memiah; Ziad A Memish; Walter Mendoza; Atte Meretoja; Tuomo J Meretoja; Francis Apolinary Mhimbira; Ted R Miller; Edward J Mills; Mojde Mirarefin; Awoke Misganaw; Charles N Mock; Karzan Abdulmuhsin Mohammad; Alireza Mohammadi; Shafiu Mohammed; Lorenzo Monasta; Julio Cesar Montañez Hernandez; Marcella Montico; Ami R Moore; Maziar Moradi-Lakeh; Lidia Morawska; Rintaro Mori; Ulrich O Mueller; Georgina A V Murphy; Srinivas Murthy; Jean B Nachega; Aliya Naheed; Kovin S Naidoo; Luigi Naldi; Devina Nand; Vinay Nangia; Subas Neupane; Charles R Newton; John N Newton; Marie Ng; Frida Namnyak Ngalesoni; Peter Nguhiu; Quyen Le Nguyen; Muhammad Imran Nisar; Patrick Martial Nkamedjie Pete; Ole F Norheim; Rosana E Norman; Felix Akpojene Ogbo; In-Hwan Oh; Foluke Adetola Ojelabi; Pedro R Olivares; Bolajoko Olubukunola Olusanya; Jacob Olusegun Olusanya; Eyal Oren; Erika Ota; P.A. Mahesh; Eun-Kee Park; Hye-Youn Park; Mahboubeh Parsaeian; Angel J Paternina Caicedo; Scott B Patten; João Mário Pedro; David M Pereira; Norberto Perico; Konrad Pesudovs; Max Petzold; Michael Robert Phillips; Julian David Pillay; Farhad Pishgar; Suzanne Polinder; Daniel Pope; Svetlana Popova; Farshad Pourmalek; Mostafa Qorbani; Rynaz H S Rabiee; Anwar Rafay; Vafa Rahimi-Movaghar; Mahfuzar Rahman; Mohammad Hifz Ur Rahman; Sajjad Ur Rahman; Rajesh Kumar Rai; Murugesan Raju; Usha Ram; Saleem M Rana; Chhabi Lal Ranabhat; Puja Rao; Amany H Refaat; Giuseppe Remuzzi; Serge Resnikoff; Alex Reynolds; David Rojas-Rueda; Luca Ronfani; Gholamreza Roshandel; Gregory A Roth; Ambuj Roy; George Mugambage Ruhago; Rajesh Sagar; Muhammad Muhammad Saleh; Juan R Sanabria; Maria Dolores Sanchez-Niño; Itamar S Santos; João Vasco Santos; Rodrigo Sarmiento-Suarez; Benn Sartorius; Maheswar Satpathy; Miloje Savic; Monika Sawhney; Ione J C Schneider; Ben Schöttker; David C Schwebel; Soraya Seedat; Sadaf G Sepanlou; Edson E Servan-Mori; Tesfaye Setegn; Saeid Shahraz; Masood Ali Shaikh; Marina Shakh-Nazarova; Rajesh Sharma; Jun She; Sara Sheikhbahaei; Jiabin Shen; Kevin N Sheth; Kenji Shibuya; Hwashin Hyun Shin; Min-Jeong Shin; Rahman Shiri; Ivy Shuie; Inga Dora Sigfusdottir; Diego Augusto Santos Silva; Jonathan Silverberg; Edgar P Simard; Shireen Sindi; Abhishek Singh; Jasvinder A Singh; Om Prakash Singh; Prashant Kumar Singh; Virendra Singh; Joan B Soriano; Sergey Soshnikov; Luciano A Sposato; Chandrashekhar T Sreeramareddy; Vasiliki Stathopoulou; Nicholas Steel; Konstantinos Stroumpoulis; Lela Sturua; Bruno F Sunguya; Soumya Swaminathan; Bryan L Sykes; Cassandra E I Szoeke; Rafael Tabarés-Seisdedos; Mohammad Tavakkoli; Bineyam Taye; Bemnet Amare Tedla; Worku Mekonnen Tefera; Tesfaye Tekle; Girma Temam Shifa; Abdullah Sulieman Terkawi; Fisaha Haile Tesfay; Gizachew Assefa Tessema; Kiran Thapa; Alan J Thomson; Andrew L Thorne-Lyman; Ruoyan Tobe-Gai; Marcello Tonelli; Roman Topor-Madry; Fotis Topouzis; Bach Xuan Tran; Christopher Troeger; Thomas Truelsen; Zacharie Tsala Dimbuene; Abera Kenay Tura; Stefanos Tyrovolas; Kingsley N Ukwaja; Chigozie Jesse Uneke; Olalekan A Uthman; Masoud Vaezghasemi; Tommi Vasankari; Ana Maria Nogales Vasconcelos; Narayanaswamy Venketasubramanian; Raj Kumar Verma; Francesco S Violante; Sergey K Vladimirov; Vasiliy Victorovich Vlassov; Stein Emil Vollset; Linhong Wang; Yanping Wang; Scott Weichenthal; Elisabete Weiderpass; Robert G Weintraub; Daniel J Weiss; Andrea Werdecker; Ronny Westerman; Marc-Alain Widdowson; Tissa Wijeratne; Thomas Neil Williams; Charles Shey Wiysonge; Charles D A Wolfe; Ingrid Wolfe; Sungho Won; Mamo Wubshet; Qingyang Xiao; Gelin Xu; Ajit Kumar Yadav; Bereket Yakob; Yuichiro Yano; Mehdi Yaseri; Pengpeng Ye; Henock Gebremedhin Yebyo; Paul Yip; Naohiro Yonemoto; Seok-Jun Yoon; Mustafa Z Younis; Chuanhua Yu; Zoubida Zaidi; Maysaa El Sayed Zaki; Hajo Zeeb; Hao Zhang; Yong Zhao; Yingfeng Zheng; Maigeng Zhou; Sanjay Zodpey; Christopher J L Murray
GBD 2015 Child Mortality Collaborators. Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 2016; 388: 1725–74—In this Article, Mohsen Naghavi, Michael J Kutz, Chantal Huynh, Samer Hamidi, Addisu Shunu Beyene, and Stephen S Lim should have been listed as authors. The affiliation details for Simon I Hay have been updated. The funding statement for Simon I Hay has been added. These corrections have been made to the online version as of Jan 5, 2017. © 2017 Elsevier Ltd
Evaluation of methotrexate encapsulated polymeric nanocarrier for breast cancer treatment
(Elsevier B.V., 2023) Rinki Verma; Virendra Singh; Biplob Koch; Manoj Kumar
Herein, Methotrexate-loaded chitosan nanoparticles (Meth-Cs-NPs) was formulated through single-step self-assembly by incorporating the ionic-gelation method. Chitosan was cross-linked with Methotrexate via a sodium tripolyphosphate (STPP) where 49 % Methotrexate was loaded in the nanoparticles (∼143 nm) and zeta potential of 34 ± 3 mV with an entrapment efficiency of 87 %. The efficacy of nanoparticles was assessed for chemically induced breast cancer treatment in the Sprague Dawley rats model. These Meth-Cs-NPs followed the Korsmeyer-Peppas model in-vitro release kinetics. Nanoparticles were further evaluated for in-vitro efficacy on triple-negative breast cancer (MDA-MB-231) cell lines. The MTT assay studies revealed that even slight exposure to Meth-Cs-NPs (IC50 = 15 µg/mL) caused 50 % cell death in 24 h. Further, hemocompatibility studies of Meth-Cs-NPs were performed, deciphered that Meth-Cs-NPs were biocompatible (hemolysis < 2 %). Additional cellular uptake was evaluated by confocal imaging. Moreover, an in-vivo pharmacokinetic study of nanoparticles in rats displayed increased plasma concentration of the drug and retention time, whereas a decrease in cellular clearance compared to free Methotrexate. Further, anti-tumor efficacy studies revealed that nanoparticles could reduce tumor volume from 1414 mm3→385 mm3 compared to free Methotrexate (1414 mm3→855 mm3). The current study presents encouraging prospects of Meth-Cs-NPs to be used as a viable breast cancer treatment modality. © 2023 Elsevier B.V.
Fabrication of gelatin coated polycaprolactone nanofiber scaffolds co-loaded with luliconazole and naringenin for treatment of Candida infected diabetic wounds
(Elsevier B.V., 2024) Manjit Manjit; Krishan Kumar; Manish Kumar; Abhishek Jha; Kanchan Bharti; Punit Tiwari; Ragini Tilak; Virendra Singh; Biplob Koch; Brahmeshwar Mishra
The current study focuses on the development of gelatin-coated polycaprolactone (PCL) nanofibers co-loaded with luliconazole and naringenin for accelerated healing of infected diabetic wounds. Inherently, PCL nanofibers have excellent biocompatibility and biodegradation profiles but lack bioadhesion characteristics, which limits their use as dressing materials. So, coating them with a biocompatible and hydrophilic material like gelatin can improve bioadhesion. The preparation of nanofibers was done with the electrospinning technique. The solid state characterization and in-vitro performance assessment of nanofibers indicate the formation of uniformly interconnected nanofibers of 200–400 nm in diameter with smooth surface topography, excellent drug entrapment, and a surface pH of 5.6–6.8. The antifungal study showed that the nanofiber matrix exhibits excellent biofilm inhibition activity against several strains of Candida. Further, in-vivo assessment of nanofiber performance on C. albicans infected wounds in diabetic rats indicated accelerated wound healing efficacy in comparison to gauge-treated groups. Additionally, a higher blood flow and rapid re-epithelialization of wound tissue in the treatment group corroborated with the results obtained in the wound closure study. Overall, the developed dual-drug-loaded electrospun nanofiber mats have good compatibility, surface properties, and excellent wound healing potential, which can provide an extra edge in the management of complex diabetic wounds. © 2024 Elsevier B.V.
Formulation and characterization of polyvinyl alcohol/chitosan composite nanofiber co-loaded with silver nanoparticle & luliconazole encapsulated poly lactic-co-glycolic acid nanoparticle for treatment of diabetic foot ulcer
(Elsevier B.V., 2024) Manjit Manjit; Manish Kumar; Abhishek Jha; Kanchan Bharti; Krishan Kumar; Punit Tiwari; Ragini Tilak; Virendra Singh; Biplob Koch; Brahmeshwar Mishra
Chronic wounds are prone to fungal infections, possess a significant challenge, and result in substantial mortality. Diabetic wounds infected with Candida strains are extremely common. It can create biofilm at the wound site, which can lead to antibiotic resistance. As a result, developing innovative dressing materials that combat fungal infections while also providing wound healing is a viable strategy to treat infected wounds and address the issue of antibiotic resistance. Present work proposed anti-infective dressing material for the treatment of fungal strains Candida-infected diabetic foot ulcer (DFU). The nanofiber was fabricated using polyvinyl Alcohol/chitosan as hydrogel base and co-loaded with silver nanoparticles (AgNP) and luliconazole-nanoparticles (LZNP) nanoparticles, prepared using PLGA. Fabricated nanofibers had pH close to target area and exhibited hydrophilic surface suitable for adhesion to wound area. The nanofibers showed strong antifungal and antibiofilm properties against different strains of Candida; mainly C. albicans, C. auris, C. krusei, C. parapsilosis and C. tropicalis. Nanofibers exhibited excellent water retention potential and water vapour transmission rate. The nanofibers had sufficient payload capacity towards AgNP and LZNP, and provided controlled release of payload, which was also confirmed by in-vivo imaging. In-vitro studies confirmed the biocompatibility and enhanced proliferation of Human keratinocytes cells (HaCaT). In-vivo studies showed accelerated wound closure by providing ant-infective action, supporting cellular proliferation and improving blood flow, all collectively contributing in expedited wound healing. © 2023 Elsevier B.V.