Browsing by Author "Vishal Chander"

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Antioxidant supplementation during treatment of outpatient dogs with parvovirus enteritis ameliorates oxidative stress and attenuates intestinal injury: A randomized controlled trial
(Elsevier B.V., 2023) Gollahalli Eregowda Chethan; Ujjwal Kumar De; Mithilesh Kumar Singh; Vishal Chander; Raguvaran Raja; Babul Rudra Paul; Om Prakash Choudhary; Neeraj Thakur; Kalyan Sarma; Hridayesh Prasad
A prospective randomized controlled clinical study was conducted to determine whether antioxidant supplementation as an adjunct therapy alters hemogram, oxidative stress, serum intestinal fatty acid binding protein-2 (IFABP-2) level, fecal viral load, clinical score (CS) and survivability in outpatient canine parvovirus enteritis (CPVE) dogs. The dogs with CPVE were randomized to one of the five treatment groups: supportive treatment (ST) alone, ST with N-acetylcysteine (ST+NAC), resveratrol (ST+RES), coenzyme Q10 (ST+CoQ10) or ascorbic acid (ST+AA). The primary outcome measures were reduction of CS and fecal HA titre, and enhancement of survivability. Secondary outcome measures were reduction of oxidative stress indices and IFABP-2 level from day 0 to day 7. The mean CS and HA titre were significantly (P < 0.05) decreased from day 0 to 7 in ST and all antioxidant groups. The supplementations of NAC, RES and AA along with ST markedly (P < 0.05) reduced the concentrations of malondialdehyde, nitric oxide and IFABP-2 on day 7 as compared to ST alone. Additionally, NAC and RES supplementations markedly (P < 0.05) improved the total leukocyte count and neutrophil count in CPVE-affected dogs. NAC and RES could serve as better antioxidants for the amelioration of oxidative stress in CPVE but, the antioxidants did not confer any additional benefits in reduction of CS, fecal HA tire, or survivability when compared with ST alone. © 2023
Concomitant infection of babesia canis, ehrlichia canis and parvovirus in dogs and its therapeutic management
(Veterinary Practitioner, 2020) Neeraj Thakur; G.E. Chethan; K. Mahendran; U.K. De; Vijayakumar Jawalagatti; Vishal Chander; J.B. Rajesh; P.S. Banerjee
The present report describes rare occurrence of concomitant infection of Babesia canis, Ehrlichia canis and parvovirus in dogs and its therapeutic management by using diminazene aceturate and doxycycline along with symptomatic and supportive therapy. © 2020, Veterinary Practitioner. All rights reserved.
Immuno-pathological and Molecular Screening of Rabies Virus in Indian Wild Felids: Unravelling Sylvatic to Urban Spillover
(2025) Rahul Ganpatrao Kadam; Mathesh Karikalan; Rajat Varshney; Chandra Mohan S; Vishal Chander; Karam Pal Singh; Anil Kumar Sharma
Rabies poses a fatal threat to humans, domestic animals, and wildlife, with its transmission often exhibiting a wave-like pattern influenced by host population density. Understanding the dynamics of reservoir hosts is critical to elucidating the spatial distribution and transmission pathways of the virus. Between 2014 and 2017, brain specimens from various wild felids in India - including tigers, lions, leopards, and other species-were screened for rabies. Of the 68 samples examined, one jungle cat (73-P/15) and one leopard (01-CD/16) tested positive, representing 2.94% of the total. The infected leopard had previously exhibited aggressive behavior toward domestic animals, resulting in the deaths of 13 cattle and 2 buffaloes due to neurological complications. To assess potential transmission from wildlife to domestic animals, brain samples from one cow and one bullock-exposed to the infected leopard-were also tested for rabies. The direct fluorescent antibody technique (dFAT) revealed the presence of rabies antigen in brain impression smears, which was further confirmed via RT-PCR. Sequencing of the PCR-amplified N gene fragments demonstrated 100% nucleotide identity among the leopard, cow, and bullock sequences, confirming direct transmission from the leopard to the livestock. Phylogenetic analysis placed these sequences within the Arctic-like 1a clade, clustering with other RABV strains circulating in India. This study underscores the importance of maintaining effective barriers between wildlife, humans, and domestic animals to prevent rabies spillover from sylvatic to urban populations.