Browsing by Author "Vivek Kumar"

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Anthropogenic Stress and Phenolic Compounds: An Environmental Robustness Diagnostics Compound Family in Stress Ameliorations
(Springer Nature, 2023) Vivek Kumar; Rajesh Kumar Singhal; Akash Hidangmayum; Ankita Singh; Bhayyalal Aanjna; Jyoti Chauhan; Bandana Bose
Natural ecosystems are progressively vulnerable to a number of multiple anthropogenic stressors, particularly with water, ozone, air pollutants, pesticides, heavy metals (HMs), deforestation, artificial lightening, agriculture intensification, and land use pattern changes. All of them have risen in ecosystem imbalance, climate change, global warming, and many other natural disasters as abiotic stresses. These stressors cause imbalance in physiological, biochemical, and molecular traits at different levels and under different environmental components, which they are subjected. Therefore, to diminish the catastrophic consequences on ecological sustainability, the present chapter focuses on the role and mechanisms of secondary metabolites (SMs) especially phenolic compounds (PCs) for environmental robustness diagnostics via adaption or avoidance from these stressors. The prime objective of this chapter tends to explore the functions and responses of PCs in respect to elevated CO2 (eCO2), heavy metal (HM) stress, salinity, pollutant translocations, and transformations in ecosystem. For instance, it will help in understanding the different anthropogenic stressors, their impact on environmental components, PC response, and pathway or mechanisms by which these PCs nullify the drastic consequences of anthropogenic stressors. © Springer Nature Singapore Pte Ltd. 2023.
Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017 (Nature Medicine, (2020), 26, 5, (750-759), 10.1038/s41591-020-0807-6)
(Nature Research, 2020) Damaris K. Kinyoki; Jennifer M. Ross; Alice Lazzar-Atwood; Sandra B. Munro; Lauren E. Schaeffer; Mahdieh Abbasalizad-Farhangi; Masoumeh Abbasi; Hedayat Abbastabar; Ahmed Abdelalim; Amir Abdoli; Mohammad Abdollahi; Ibrahim Abdollahpour; Rizwan Suliankatchi Abdulkader; Nebiyu Dereje Abebe; Teshome Abuka Abebo; Kedir Hussein Abegaz; Hassan Abolhassani; Lucas Guimarães Abreu; Michael R. M. Abrigo; Abdelrahman I. Abushouk; Manfred Mario Kokou Accrombessi; Dilaram Acharya; Maryam Adabi; Akindele Olupelumi Adebiyi; Isaac Akinkunmi Adedeji; Victor Adekanmbi; Abiodun Moshood Adeoye; Olatunji O. Adetokunboh; Davoud Adham; Posi Emmanuel Aduroja; Shailesh M. Advani; Mohsen Afarideh; Mohammad Aghaali; Anurag Agrawal; Tauseef Ahmad; Keivan Ahmadi; Sepideh Ahmadi; Muktar Beshir Ahmed; Rushdia Ahmed; Olufemi Ajumobi; Chalachew Genet Akal; Temesgen Yihunie Akalu; Tomi Akinyemiju; Blessing Akombi; Ziyad Al-Aly; Samiah Alam; Genet Melak Alamene; Turki M. Alanzi; Jacqueline Elizabeth Alcalde Rabanal; Niguse Meles Alema; Beriwan Abdulqadir Ali; Muhammad Ali; Mehran Alijanzadeh; Cyrus Alinia; Vahid Alipour; Hesam Alizade; Syed Mohamed Aljunid; Afshin Almasi; Amir Almasi-Hashiani; Hesham M. Al-Mekhlafi; Rajaa M. Al-Raddadi; Khalid Altirkawi; Nelson Alvis-Guzman; Nelson J. Alvis-Zakzuk; Azmeraw T. Amare; Adeladza Kofi Amegah; Saeed Amini; Mostafa Amini Rarani; Fatemeh Amiri; Arianna Maever Loreche Amit; Nahla Hamed Anber; Catalina Liliana Andrei; Fereshteh Ansari; Alireza Ansari-Moghaddam; Zelalem Alamrew Anteneh; Carl Abelardo T. Antonio; Ernoiz Antriyandarti; Davood Anvari; Razique Anwer; Seth Christopher Yaw Appiah; Jalal Arabloo; Morteza Arab-Zozani; Ephrem Mebrahtu Araya; Zohreh Arefi; Olatunde Aremu; Johan Ärnlöv; Afsaneh Arzani; Mehran Asadi-Aliabadi; Ali A. Asadi-Pooya; Samaneh Asgari; Babak Asghari; Alebachew Fasil Ashagre; Anemaw A. Asrat; Bahar Ataeinia; Hagos Tasew Atalay; Desta Debalkie Atnafu; Maha Moh’d Wahbi Atout; Marcel Ausloos; Euripide F. G. A. Avokpaho; Ashish Awasthi; Beatriz Paulina Ayala Quintanilla; Martin Amogre Ayanore; Yared A. Asmare Aynalem; Abbas Azadmehr; Samad Azari; Ghasem Azarian; Zelalem Nigussie Azene; Ebrahim Babaee; Alaa Badawi; Ashish D. Badiye; Mohamad Amin Bahrami; Atif Amin A. Baig; Ahad Bakhtiari; Shankar M. Bakkannavar; Senthilkumar Balakrishnan; Ayele Geleto Bali; Maciej Banach; Palash Chandra Banik; Zahra Baradaran-Seyed; Adhanom Gebreegziabher Baraki; Miguel A. Barboza; Till Winfried Bärnighausen; Lingkan Barua; Huda Basaleem; Sanjay Basu; Mohsen Bayati; Mulat Tirfie Bayih; Habtamu Wondifraw Baynes; Neeraj Bedi; Masoud Behzadifar; Meysam Behzadifar; Yibeltal Alemu Bekele; Derrick A. Bennett; Dessalegn Ajema Berbada; Kidanemaryam Berhe; Abadi Kidanemariam Berhe; Adam E. Berman; Robert S. Bernstein; Reshmi Bhageerathy; Dinesh Bhandari; Pankaj Bharadwaj; Natalia V. Bhattacharjee; Krittika Bhattacharyya; Ali Bijani; Boris Bikbov; Ver Bilano; Nigus Bililign; Muhammad Shahdaat Bin Sayeed; Setognal Birara; Minuye Biniam Biniam Birhane; Minyichil Birhanu; Raaj Kishore Biswas; Zebenay Workneh Bitew; Kassawmar Angaw Bogale; Somayeh Bohlouli; Srinivasa Rao Bolla; Archith Boloor; Antonio M. Borzì; Shiva Borzouei; Oliver J. Brady; Nicola Luigi Bragazzi; Dejana Braithwaite; Nikolay Ivanovich Briko; Gabrielle Britton; Shyam S. Budhathoki; Sharath Burugina Nagaraja; Reinhard Busse; Zahid A. Butt; Lucero Cahuana-Hurtado; Luis Alberto Cámera; Ismael R. Campos-Nonato; Jorge Cano; Josip Car; Rosario Cárdenas; Juan J. Carrero; Félix Carvalho; João Mauricio Castaldelli-Maia; Carlos A. Castañeda-Orjuela; Franz Castro; Ester Cerin; Collins Chansa; Jaykaran Charan; Pranab Chatterjee; Vijay Kumar Chattu; Bal Govind Chauhan; Ali Reza Chavshin; Mohammad Chehrazi; Tesfaye Yitna Chichiabellu; Ken Lee Chin; Devasahayam J. Christopher; Dinh-Toi Chu; Flavia M. Cicuttini; Michael L. Collison; Michael A. Cork; Natalie Cormier; Paolo Angelo Cortesi; Vera M. Costa; Abel Fekadu Fekadu Dadi; Baye Dagnew; Saad M. A. Dahlawi; Giovanni Damiani; Amira Hamed Darwish; Ahmad Daryani; Jai K. Das; Rajat Das Gupta; Claudio Dávila-Cervantes; Nicole Davis Weaver; Diego De Leo; Jan-Walter De Neve; Feleke Mekonnen Demeke; Asmamaw Bizuneh Demis; Dereje Bayissa Demissie; Gebre Teklemariam Demoz; Edgar Denova-Gutiérrez; Kebede Deribe; Rupak Desai; Beruk Berhanu Desalegn; Assefa Desalew; Aniruddha Deshpande; Sagnik Dey; Samath Dhamminda Dharmaratne; Preeti Dhillon; Meghnath Dhimal; Govinda Prasad Dhungana; Mostafa Dianati Nasab; Daniel Diaz; Zahra Sadat Dibaji Forooshani; Girmaye Deye Dinsa; Isaac Oluwafemi Dipeolu; Shirin Djalalinia; Hoa Thi Do; Huyen Phuc Do; Paul Narh Doku; Fariba Dorostkar; Leila Doshmangir; Manisha Dubey; Bereket Duko Adema; Susanna J. Dunachie; Bruce B. Duncan; Ewerton Cousin; Andre R. Durães; Lucas Earl; Hamed Ebrahimzadeh Leylabadlo; Aziz Eftekhari; Iman El Sayed; Maysaa El Sayed Zaki; Maha El Tantawi; Iffat Elbarazi; Demelash Abewa Elemineh; Shaimaa I. El-Jaafary; Ziad El-Khatib; Aisha Elsharkawy; Yasser Mohamed El-Sherbiny; Iqbal R. F. Elyazar; Mohammad Hassan Emamian; Shymaa Enany; Daniel Adane Endalew; Melese Linger Endalifer; Khalil Eskandari; Sharareh Eskandarieh; Saman Esmaeilnejad; Alireza Esteghamati; Arash Etemadi; Atkilt Esaiyas Etisso; Jessica Fanzo; Mohammad Farahmand; Anwar Faraj; Sajjad Farashi; Mohammad Fareed; Andrea Farioli; Andre Faro; Farshad Farzadfar; Hossein Farzam; Syeda Sadia Fatima; Nazir Fattahi; Nelsensius Klau Fauk; Ali Akbar Fazaeli; Netsanet Fentahun; Tomas Y. Ferede; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; João C. Fernandes; Garumma Tolu Feyissa; Irina Filip; Florian Fischer; Carsten Flohr; Nataliya A. Foigt; Morenike Oluwatoyin Folayan; Artem Alekseevich Fomenkov; Masoud Foroutan; Jana Förster; Joel Msafiri Francis; Takeshi Fukumoto; Reta Tsegaye Gayesa; Biniyam Sahiledengle Geberemariyam; Tsegaye Tewelde Gebrehiwot; Hadush Gebremariam; Kidane Tadesse Gebremariam; Ketema Bizuwork Bizuwork Gebremedhin; Gebreamlak Gebremedhn Gebremeskel; Assefa Ayalew Ayalew Gebreslassie; Gebretsadkan G. G. Gebretsadik; Getnet Azeze Gedefaw; Yilma Chisha Dea Geramo; Hailay Abrha Gesesew; Birhanu Geta; Agegnehu Bante Getenet; Kebede Embaye Gezae; Fatemeh Ghaffarifar; Mansour Ghafourifard; Alireza Ghajar; Mahsa Ghajarzadeh; Ahmad Ghashghaee; Hesam Ghiasvand; Asadollah Gholamian; Syed Amir Gilani; Tiffany K. Gill; Ibrahim Abdelmageed Ginawi; Srinivas Goli; Nelson G. M. Gomes; Sameer Vali Gopalani; Houman Goudarzi; Alessandra C. Goulart; Arunkumar Govindakarnavar; Ayman Grada; Michal Grivna; Rafael Alves Guimarães; Rashid Abdi Guled; Yuming Guo; Rahul Gupta; Rajeev Gupta; Nima Hafezi-Nejad; Michael Tamene Haile; Arvin Haj-Mirzaian; Arya Haj-Mirzaian; Brian J. Hall; Iman Halvaei; Randah R. Hamadeh; Yadollah Hamidi; Demelash Woldeyohannes Handiso; Graeme J. Hankey; Hamidreza Haririan; Ninuk Hariyani; Ahmed I. Hasaballah; Md. Mehedi Hasan; Milad Hasankhani; Edris Hasanpoor; Amir Hasanzadeh; Maryam Hashemian; Soheil Hassanipour; Hamid Yimam Hassen; Rasmus Havmoeller; Corinna Hawkes; Khezar Hayat; Desta Haftu Hayelom; Behnam Heidari; Reza Heidari-Soureshjani; Delia Hendrie; Andualem Henok; Nathaniel J. Henry; Mario Herrero; Claudiu Herteliu; Fatemeh Heydarpour; Hagos D. de Hidru; Chi Linh Hoang; Hans W. Hoek; Michael K. Hole; Ramesh Holla; Gillian Hollerich; Enayatollah Homaie Rad; Sung Hwi Hong; Praveen Hoogar; Masako Horino; Naznin Hossain; Mostafa Hosseini; Mehdi Hosseinzadeh; Mihaela Hostiuc; Sorin Hostiuc; Mowafa Househ; Mohamed Hsairi; Guoqing Hu; Tanvir M. Huda; Ayesha Humayun; Bing-Fang Hwang; Segun Emmanuel Ibitoye; Olayinka Stephen Ilesanmi; Milena D. Ilic; Mohammad Hasan Imani-Nasab; Leeberk Raja Inbaraj; Usman Iqbal; Seyed Sina Naghibi Irvani; Sheikh Mohammed Shariful Islam; Chidozie C. D. Iwu; Chinwe Juliana Iwu; Neda Izadi; Jalil Jaafari; Anelisa Jaca; Farhad Jadidi-Niaragh; Nader Jafari Balalami; Morteza Jafarinia; Mohammad Ali Jahani; Mihajlo Jakovljevic; Amir Jalali; Farzad Jalilian; Achala Upendra Jayatilleke; Panniyammakal Jeemon; Fyezah Jehan; Ensiyeh Jenabi; Ravi Prakash Jha; Vivekanand Jha; John S. Ji; Peng Jia; Oommen John; Yetunde O. John-Akinola; Kimberly B. Johnson; Jost B. Jonas; Nitin Joseph; Farahnaz Joukar; Jacek Jerzy Jozwiak; Suresh Banayya Jungari; Mikk Jürisson; Ali Kabir; Zubair Kabir; Amaha Kahsay; Molla Kahssay; Hamed Kalani; Leila L. Kalankesh; Rohollah Kalhor; Zahra Kamiab; Tanuj Kanchan; Umesh Kapil; Neeti Kapoor; Manoochehr Karami; Behzad Karami Matin; André Karch; Mohd A. Karim; Surendra Karki; Amir Kasaeian; Gebremicheal Gebreslassie Kasahun; Habtamu Kebebe Kasaye; Tesfaye Dessale Kassa; Hagazi Gebremedhin Kassaye; Nicholas J. Kassebaum; Ali Kazemi Karyani; Andre Pascal Kengne; Daniel Bekele Ketema; Yousef Saleh Khader; Morteza Abdullatif Khafaie; Mojtaba Khaksarian; Nauman Khalid; Ibrahim A. Khalil; Rovshan Khalilov; Asad Khan; Ejaz Ahmad Khan; Md Nuruzzaman Khan; Mohammad Saud Khan; Muhammad Shahzeb Khan; Khaled Khatab; Amir Khater; Mona M. Khater; Mahalqua Nazli Khatib; Maryam Khayamzadeh; Maryam Khazaei-Pool; Mohammad Khazaei; Salman Khazaei; Mohammad Taghi Khodayari; Mohammad Hossein Khosravi; Roba Khundkar; Ali Kiadaliri; Neda Kianipour; Daniel N. Kiirithio; Yun Jin Kim; Ruth W. Kimokoti; Adnan Kisa; Sezer Kisa; Tufa Kolola; Hamidreza Komaki; Shivakumar K. M. Kondlahalli; Ali Koolivand; Parvaiz A. Koul; Ai Koyanagi; Moritz U. G. Kraemer; Kewal Krishan; Kris J. Krohn; Nuworza Kugbey; Manasi Kumar; Pushpendra Kumar; Vivek Kumar; Om P. Kurmi; Oluwatosin Kuti; Carlo La Vecchia; Ben Lacey; Deepesh P. Lad; Aparna Lal; Dharmesh Kumar Lal; Faris Hasan Lami; Prabhat Lamichhane; Justin J. Lang; Van C. Lansingh; Savita Lasrado; Georgy Lebedev; Paul H. Lee; Shaun Wen Huey Lee; Mostafa Leili; Ian D. Letourneau; Sonia Lewycka; Shanshan Li; Lee-Ling Lim; Shai Linn; Shiwei Liu; Simin Liu; Rakesh Lodha; Joshua Longbottom; Jaifred Christian F. Lopez; Stefan Lorkowski; Erlyn Rachelle King Macarayan; Mohammed Madadin; Hassan Magdy Abd El Razek; Muhammed Magdy Abd El Razek; Dhaval P. Maghavani; Phetole Walter Mahasha; Narayan Bahadur Mahotra; Venkatesh Maled; Afshin Maleki; Shokofeh Maleki; Deborah Carvalho Malta; Ali Manafi; Farzad Manafi; Navid Manafi; Narendar Dawanu Manohar; Fariborz Mansour-Ghanaei; Borhan Mansouri; Mohammad Ali Mansournia; Chabila Christopher Mapoma; Dadi Marami; Laurie B. Marczak; Carlos Alberto Marrugo Arnedo; Francisco Rogerlândio Martins-Melo; Anthony Masaka; Benjamin Ballard Massenburg; Pallab K. Maulik; Benjamin K. Mayala; Mohsen Mazidi; Man Mohan Mehndiratta; Freshteh Mehri; Kala M. Mehta; Wahengbam Bigyananda Meitei; Fantahun Ayenew Mekonnen; Teferi Mekonnen; Gebrekiros Gebremichael Meles; Hagazi Gebre Meles; Addisu Melese; Walter Mendoza; Ritesh G. Menezes; Meresa Berwo Mengesha; George A. Mensah; Tuomo J. Meretoja; Tomasz Miazgowski; Neda Milevska Kostova; Ted R. Miller; Edward J. Mills; G.K. Mini; Seyed Mostafa Mir; Mohammad Miri; Hamed Mirjalali; Erkin M. Mirrakhimov; Hamed Mirzaei; Maryam Mirzaei; Roya Mirzaei; Mehdi Mirzaei-Alavijeh; Prasanna Mithra; Babak Moazen; Efat Mohamadi; Amjad Mohamadi-Bolbanabad; Karzan Abdulmuhsin Mohammad; Yousef Mohammad; Dara K. Mohammad; Aso Mohammad Darwesh; Naser Mohammad Gholi Mezerji; Abdollah Mohammadian-Hafshejani; Mousa Mohammadnia-Afrouzi; Milad Mohammadoo-Khorasani; Reza Mohammadpourhodki; Salahuddin Mohammed; Shafiu Mohammed; Jemal Abdu Mohammed; Ammas Siraj Mohammed; Farnam Mohebi; Amin Mokari; Ali H. Mokdad; Julio Cesar Montañez; Pablo A. Montero-Zamora; Yoshan Moodley; Maryam Moossavi; Ghobad Moradi; Masoud Moradi; Yousef Moradi; Mohammad Moradi-Joo; Maziar Moradi-Lakeh; Farhad Moradpour; Rahmatollah Moradzadeh; Paula Moraga; Shane Douglas Morrison; Abbas Mosapour; Jonathan F. Mosser; Simin Mouodi; Amin Mousavi Khaneghah; Dariush Mozaffarian; Ulrich Otto Mueller; Christopher J. L. Murray; G.V.S. Murthy; Kamarul Imran Musa; Ghulam Mustafa; Saravanan Muthupandian; Behnam Nabavizadeh; Mehdi Naderi; Girish N. Nadkarni; Ahamarshan Jayaraman Nagarajan; Mohsen Naghavi; Aliya Naheed; Gurudatta Naik; Farid Najafi; Jobert Richie Nansseu; K. M. Venkat Narayan; Bruno Ramos Nascimento; Vinod Nayak; Javad Nazari; Duduzile Edith Ndwandwe; Ionut Negoi; Ruxandra Irina Negoi; Josephine W. Ngunjiri; Cuong Tat Nguyen; Huong Lan Thi Nguyen; Dabere Nigatu; Yeshambel T. Nigatu; Rajan Nikbakhsh; Dina Nur Anggraini Ningrum; Chukwudi A. Nnaji; Vuong Minh Nong; Jean Jacques Noubiap; Christoph Nowak; Bogdan Oancea; Richard Ofori-Asenso; Onome Bright Oghenetega; In-Hwan Oh; Olanrewaju Oladimeji; Morteza Oladnabi; Andrew T. Olagunju; Tinuke O. Olagunju; Bolajoko Olubukunola Olusanya; Jacob Olusegun Olusanya; Mojisola Morenike Oluwasanu; Muktar Omer Omer; Obinna E. Onwujekwe; Kwaku Oppong Asante; Eyal Oren; Orish Ebere Orisakwe; Alberto Ortiz; Osayomwanbo Osarenotor; Aaron E. Osgood-Zimmerman; Mayowa Ojo Owolabi; Mahesh P. A; Jagadish Rao Padubidri; Keyvan Pakshir; Adrian Pana; Songhomitra Panda-Jonas; Hadi Parsian; Tahereh Pashaei; Deepak Kumar Pasupula; Sangram Kishor Patel; Ashish Pathak; Mona Pathak; Sanghamitra Pati; Ajay Patle; George C. Patton; Kebreab Paulos; Hamidreza Pazoki Toroudi; Veincent Christian Filipino Pepito; Norberto Perico; William A. Petri; Brandon V. Pickering; David M. Pigott; Majid Pirestani; Bakhtiar Piroozi; Meghdad Pirsaheb; Khem Narayan Pokhrel; Maarten J. Postma; Hadi Pourjafar; Farshad Pourmalek; Reza Pourmirza Kalhori; Akram Pourshams; Hossein Poustchi; Sergio I. Prada; Liliana Preotescu; Dimas Ria Angga Pribadi; Zahiruddin Quazi Syed; Mohammad Rabiee; Navid Rabiee; Amir Radfar; Alireza Rafiei; Fakher Rahim; Vafa Rahimi-Movaghar; Muhammad Aziz Rahman; Sajjad ur Rahman; Rajesh Kumar Rai; Ali Rajabpour-Sanati; Fatemeh Rajati; Kiana Ramezanzadeh; Saleem Muhammad Rana; Chhabi Lal Ranabhat; Sowmya J. Rao; Davide Rasella; Vahid Rashedi; Prateek Rastogi; Priya Rathi; Salman Rawaf; David Laith Rawaf; Lal Rawal; Sarah E. Ray; Giuseppe Remuzzi; Vishnu Renjith; Andre M. N. Renzaho; Serge Resnikoff; Nima Rezaei; Shahab Rezaeian; Mohammad Sadegh Rezai; Aziz Rezapour; Seyed Mohammad Riahi; Ana Isabel Ribeiro; Jennifer Rickard; Alina Rodriguez; Leonardo Roever; Elias Merdassa Roro; Gholamreza Roshandel; Ali Rostami; Enrico Rubagotti; Anas M. Saad; Seyedmohammad Saadatagah; Yogesh Damodar Sabde; Siamak Sabour; Ehsan Sadeghi; Masoumeh Sadeghi; Saeed Safari; Yahya Safari; Hamid Safarpour; Rajesh Sagar; Amirhossein Sahebkar; Mohammad Ali Sahraian; S. Mohammad Sajadi; Mohammad Reza Salahshoor; Nasir Salam; Farkhonde Salehi; Saleh Salehi Zahabi; Hosni Salem; Marwa R. Rashad Salem; Yahya Salimi; Hamideh Salimzadeh; Hossein Samadi Kafil; Evanson Zondani Sambala; Abdallah M. Samy; Itamar S. Santos; Bruno Piassi Sao Jose; Sivan Yegnanarayana Iyer Saraswathy; Abdur Razzaque Sarker; Benn Sartorius; Arash Sarveazad; Brijesh Sathian; Maheswar Satpathy; Sonia Saxena; Mehdi Sayyah; Alyssa N. Sbarra; Megan F. Schipp; Maria Inês Schmidt; Aletta Elisabeth Schutte; David C. Schwebel; Anbissa Muleta Senbeta; Subramanian Senthilkumaran; Seyedmojtaba Seyedmousavi; Faramarz Shaahmadi; Omid Shafaat; Saeed Shahabi; Masood Ali Shaikh; Ali S. Shalash; Mehran Shams-Beyranvand; Amir Shamshirian; Morteza Shamsizadeh; Mohammed Shannawaz; Kiomars Sharafi; Mehdi Sharif; Rajesh Sharma; Hatem Samir Shehata; Abbas Sheikhtaheri; Kenji Shibuya; Wondimeneh Shibabaw Shiferaw; Mika Shigematsu; Jae Il Shin; Rahman Shiri; Reza Shirkoohi; Ivy Shiue; Kerem Shuval; Soraya Siabani; Tariq J. Siddiqi; Inga Dora Sigfusdottir; Diego Augusto Santos Silva; Biagio Simonetti; Ambrish Singh; Pushpendra Singh; Virendra Singh; Jasvinder A. Singh; Pankaj Kumar Singh; Dhirendra Narain Sinha; Yitagesu Sintayehu; Malede Mequanent M. Sisay; Amin Soheili; Bija Soleymani; Farzaneh Soltani; Shahin Soltani; Joan B. Soriano; Muluken Bekele Sorrie; Sergey Soshnikov; Ireneous N. Soyiri; Adel Spotin; Chandrashekhar T. Sreeramareddy; Rajni Kant Kant Srivastava; Antonina Starodubova; Agus Sudaryanto; Mu’awiyyah Babale Sufiyan; Hafiz Ansar Rasul Suleria; Gerhard Sulo; Bruno F. Sunguya; Bryan L. Sykes; Rafael Tabarés-Seisdedos; Takahiro Tabuchi; Birkneh Tilahun Tadesse; Amir Taherkhani; Koku Sisay Tamirat; Segen Gebremeskel Tassew; Nuno Taveira; Berhane Fseha Teklehaimanot; Gebretsadkan Hintsa Tekulu; Mohamad-Hani Temsah; Abdullah Sulieman Terkawi; Zemenu Tadesse Tessema; Nihal Thomas; Mariya Vladimirovna Titova; Kenean Getaneh Tlaye; Hamid Reza Tohidinik; Marcello Tonelli; Marcos Roberto Tovani-Palone; Eugenio Traini; Khanh Bao Tran; Manjari Tripathi; Riaz Uddin; Irfan Ullah; Bhaskaran Unnikrishnan; Era Upadhyay; Ushotanefe Useh; Muhammad Shariq Usman; Olalekan A. Uthman; Marco Vacante; Masoud Vaezghasemi; Pascual R. Valdez; John VanderHeide; Elena Varavikova; Santosh Varughese; Tommi Juhani Vasankari; Yasser Vasseghian; Yousef Veisani; Srinivasaraghavan Venkatesh; Narayanaswamy Venketasubramanian; Madhur Verma; Simone Vidale; Francesco S. Violante; Vasily Vlassov; Sebastian Vollmer; Rade Vukovic; Yasir Waheed; Haidong Wang; Yafeng Wang; Yuan-Pang Wang; Girmay Teklay Weldesamuel; Andrea Werdecker; Taweewat Wiangkham; Kirsten E. Wiens; Tissa Wijeratne; Haileab Fekadu Wolde; Dawit Zewdu Wondafrash; Tewodros Eshete Wonde; Adam Belay Wondmieneh; Ai-Min Wu; Gelin Xu; Abbas Yadegar; Ali Yadollahpour; Seyed Hossein Yahyazadeh Jabbari; Tomohide Yamada; Yuichiro Yano; Sanni Yaya; Vahid Yazdi-Feyzabadi; Alex Yeshaneh; Yigizie Yeshaw; Yordanos Gizachew Yeshitila; Mekdes Tigistu Yilma; Paul Yip; Naohiro Yonemoto; Seok-Jun Yoon; Yoosik Youm; Mustafa Z. Younis; Zabihollah Yousefi; Hebat-Allah Salah A. Yousof; Chuanhua Yu; Hasan Yusefzadeh; Telma Zahirian Moghadam; Leila Zaki; Sojib Bin Zaman; Mohammad Zamani; Maryam Zamanian; Hamed Zandian; Hadi Zarafshan; Nejimu Biza Zepro; Taddese Alemu Zerfu; Taye Abuhay Zewale; Yunquan Zhang; Zhi-Jiang Zhang; Xiu-Ju Zhao; Sanjay Zodpey; Kamiar Zomorodian; Francis Bruno Zotor; Ashkan Afshin; Simon I. Hay
An amendment to this paper has been published and can be accessed via a link at the top of the paper. © 2020, The Author(s).
Cadmium toxicity in plants and alleviation through seed priming approach
(Springer, 2021) Navneet Kumar; Vivek Kumar; Bandana Bose; Rajesh Kumar Singhal
Heavy metals (Cd) contamination of soil and water due to anthropogenic activity, causing toxicity/stress, has potential to turn down the crop productivity and quality globally. Cd affects the fundamental and crucial processes of plants from seed germination to grain maturity, among them antioxidant defense and photosynthesis are prime one. Recent development in various disciplines of agricultural and biological sciences such as molecular breeding, integrative multiomics, and advance agronomical technology involved in heavy metal tolerance, although they are limited to lab conditions or less popular among farmers fields. Therefore, seed priming is promising and versatile approach to heavy metal stress tolerance. Seed priming with various organic and inorganic salts (CaCl2, Mg (NO3)2, proline), plant growth regulators (auxin, gibberellins, salicylic acid), showed the promising results in counteracts the effect of Cd. Seed priming involve in improvements of seed germination, seedling establishment, antioxidant defense, water and mineral nutrition, and carrying stress memory in progenies. To consider the above points, this review summarizes the effect of Cd toxicity on plant system and mineral nutrition. We also provide a glance of seed priming technology in respect to Cd stress tolerance at physiological, biochemical and molecular levels at different plant growth stages. © 2021, Indian Society for Plant Physiology.
Crucial Cell Signaling Compounds Crosstalk and Integrative Multi-Omics Techniques for Salinity Stress Tolerance in Plants
(Frontiers Media S.A., 2021) Rajesh K. Singhal; Debanjana Saha; Milan Skalicky; Udit N. Mishra; Jyoti Chauhan; Laxmi P. Behera; Devidutta Lenka; Subhash Chand; Vivek Kumar; Prajjal Dey; Indu; Saurabh Pandey; Pavla Vachova; Aayushi Gupta; Marian Brestic; Ayman El Sabagh
In the era of rapid climate change, abiotic stresses are the primary cause for yield gap in major agricultural crops. Among them, salinity is considered a calamitous stress due to its global distribution and consequences. Salinity affects plant processes and growth by imposing osmotic stress and destroys ionic and redox signaling. It also affects phytohormone homeostasis, which leads to oxidative stress and eventually imbalances metabolic activity. In this situation, signaling compound crosstalk such as gasotransmitters [nitric oxide (NO), hydrogen sulfide (H2S), hydrogen peroxide (H2O2), calcium (Ca), reactive oxygen species (ROS)] and plant growth regulators (auxin, ethylene, abscisic acid, and salicylic acid) have a decisive role in regulating plant stress signaling and administer unfavorable circumstances including salinity stress. Moreover, recent significant progress in omics techniques (transcriptomics, genomics, proteomics, and metabolomics) have helped to reinforce the deep understanding of molecular insight in multiple stress tolerance. Currently, there is very little information on gasotransmitters and plant growth regulator crosstalk and inadequacy of information regarding the integration of multi-omics technology during salinity stress. Therefore, there is an urgent need to understand the crucial cell signaling crosstalk mechanisms and integrative multi-omics techniques to provide a more direct approach for salinity stress tolerance. To address the above-mentioned words, this review covers the common mechanisms of signaling compounds and role of different signaling crosstalk under salinity stress tolerance. Thereafter, we mention the integration of different omics technology and compile recent information with respect to salinity stress tolerance. © Copyright © 2021 Singhal, Saha, Skalicky, Mishra, Chauhan, Behera, Lenka, Chand, Kumar, Dey, Indu, Pandey, Vachova, Gupta, Brestic and El Sabagh.
Efficient removal of endocrine disrupting compounds 17 α-ethynyl estradiol and 17 β-estradiol by Enterobacter sp. strain BHUBP7 and elucidation of the degradation pathway by HRAMS analysis
(Springer Science and Business Media B.V., 2023) Chandra Prakash; Vivek Kumar; Venkatesh Chaturvedi
Owing to the increased population and their overuse, estrogens are being detected in the environment at alarming levels. They act as endocrine disrupting compounds (EDC’s) posing adverse effects on animals and humans. In this study, a strain belonging to Enterobacter sp. strain BHUBP7 was recovered from a Sewage Treatment Plant (STP) situated in Varanasi city, U.P., India, and was capable of metabolizing both 17 α-Ethynylestradiol (EE2) and 17 β-Estradiol (E2) separately as a sole carbon source. The strain BHUBP7 exhibited high rates of E2 degradation as compared to EE2 degradation. The degradation of E2 (10 mg/L) was 94.3% after four days of incubation, whereas the degradation of EE2 (10 mg/L) under similar conditions was 98% after seven days of incubation. The kinetics of EE2 and E2 degradation fitted well with the first-order reaction rate. FTIR analysis revealed the involvement of functional groups like C = O, C–C, C–OH during the degradation process. The metabolites generated during degradation of EE2 and E2 were identified using HRAMS and a plausible pathway was elucidated. It was observed that metabolism of both E2 and EE2 proceeded with the formation of estrone, which was then hydroxylated to 4-hydroxy estrone, followed by ring opening at the C4–C5 position, and was further metabolized by the 4,5 seco pathway leading to the formation of 3-(7a-methyl-1,5-dioxooctahydro-1H-inden-4-yl) propanoic acid (HIP). It is the first report on the complete pathway of EE2 and E2 degradation in Enterobacter sp. strain BHUBP7. Moreover, the formation of Reactive Oxygen Species (ROS) during the degradation of EE2 and E2 was observed. It was concluded that both hormones elicited the generation of oxidative stress in the bacterium during the degradation process. © 2023, The Author(s), under exclusive licence to Springer Nature B.V.
Estimating global injuries morbidity and mortality: Methods and data used in the Global Burden of Disease 2017 study
(BMJ Publishing Group, 2020) Spencer L. James; Chris D. Castle; Zachary V. Dingels; Jack T. Fox; Erin B. Hamilton; Zichen Liu; Nicholas L. S. Roberts; Dillon O. Sylte; Gregory J. Bertolacci; Matthew Cunningham; Nathaniel J. Henry; Kate E. Legrand; Ahmed Abdelalim; Ibrahim Abdollahpour; Rizwan Suliankatchi Abdulkader; Aidin Abedi; Kedir Hussein Abegaz; Akine Eshete Abosetugn; Abdelrahman I. Abushouk; Oladimeji M. Adebayo; Jose C. Adsuar; Shailesh M. Advani; Marcela Agudelo-Botero; Tauseef Ahmad; Muktar Beshir Ahmed; Rushdia Ahmed; Miloud Taki Eddine Aichour; Fares Alahdab; Fahad Mashhour Alanezi; Niguse Meles Alema; Biresaw Wassihun Alemu; Suliman A. Alghnam; Beriwan Abdulqadir Ali; Saqib Ali; Cyrus Alinia; Vahid Alipour; Syed Mohamed Aljunid; Amir Almasi-Hashiani; Nihad A. Almasri; Khalid Altirkawi; Yasser Sami Abdeldayem Amer; Catalina Liliana Andrei; Alireza Ansari-Moghaddam; Carl Abelardo T. Antonio; Davood Anvari; Seth Christopher Yaw Appiah; Jalal Arabloo; Morteza Arab-Zozani; Zohreh Arefi; Olatunde Aremu; Filippo Ariani; Amit Arora; Malke Asaad; Beatriz Paulina Ayala Quintanilla; Getinet Ayano; Martin Amogre Ayanore; Ghasem Azarian; Alaa Badawi; Ashish D. Badiye; Atif Amin Baig; Mohan Bairwa; Ahad Bakhtiari; Arun Balachandran; Maciej Banach; Srikanta K. Banerjee; Palash Chandra Banik; Amrit Banstola; Suzanne Lyn Barker-Collo; Till Winfried Bärnighausen; Akbar Barzegar; Mohsen Bayati; Shahrzad Bazargan-Hejazi; Neeraj Bedi; Masoud Behzadifar; Habte Belete; Derrick A. Bennett; Isabela M. Bensenor; Kidanemaryam Berhe; Akshaya Srikanth Bhagavathula; Pankaj Bhardwaj; Anusha Ganapati Bhat; Krittika Bhattacharyya; Zulfiqar A. Bhutta; Sadia Bibi; Ali Bijani; Archith Boloor; Guilherme Borges; Rohan Borschmann; Antonio Maria Borzì; Soufiane Boufous; Dejana Braithwaite; Nikolay Ivanovich Briko; Traolach Brugha; Shyam S. Budhathoki; Josip Car; Rosario Cárdenas; Félix Carvalho; João Mauricio Castaldelli-Maia; Carlos A. Castañeda-Orjuela; Giulio Castelpietra; Ferrán Catalá-López; Ester Cerin; Joht S. Chandan; Jens Robert Chapman; Vijay Kumar Chattu; Soosanna Kumary Chattu; Irini Chatziralli; Neha Chaudhary; Daniel Youngwhan Cho; Jee-Young J. Choi; Mohiuddin Ahsanul Kabir Chowdhury; Devasahayam J. Christopher; Dinh-Toi Chu; Flavia M. Cicuttini; João M. Coelho; Vera M. Costa; Saad M. A. Dahlawi; Ahmad Daryani; Claudio Alberto Dávila-Cervantes; Diego De Leo; Feleke Mekonnen Demeke; Gebre Teklemariam Demoz; Desalegn Getnet Demsie; Kebede Deribe; Rupak Desai; Mostafa Dianati Nasab; Diana Dias Da Silva; Zahra Sadat Dibaji Forooshani; Hoa Thi Do; Kerrie E. Doyle; Tim Robert Driscoll; Eleonora Dubljanin; Bereket Duko Adema; Arielle Wilder Eagan; Demelash Abewa Elemineh; Shaimaa I. El-Jaafary; Ziad El-Khatib; Christian Lycke Ellingsen; Maysaa El Sayedzaki; Sharareh Eskandarieh; Oghenowede Eyawo; Pawan Sirwan Faris; Andre Faro; Farshad Farzadfar; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; Pietro Ferrara; Florian Fischer; Morenike Oluwatoyin Folayan; Artem Alekseevich Fomenkov; Masoud Foroutan; Joel Msafiri Francis; Richard Charles Franklin; Takeshi Fukumoto; Biniyam Sahiledengle Geberemariyam; Hadush Gebremariam; Ketema Bizuwork Gebremedhin; Leake G. Gebremeskel; Gebreamlak Gebremedhn Gebremeskel; Berhe Gebremichael; Getnet Azeze Gedefaw; Birhanu Geta; Agegnehu Bante Getenet; Mansour Ghafourifard; Farhad Ghamari; Reza Ghanei Gheshlagh; Asadollah Gholamian; Syed Amir Gilani; Tiffany K. Gill; Amir Hossein Goudarzian; Alessandra C. Goulart; Ayman Grada; Michal Grivna; Rafael Alves Guimarães; Yuming Guo; Gaurav Gupta; Juanita A. Haagsma; Brian James Hall; Randah R. Hamadeh; Samer Hamidi; Demelash Woldeyohannes Handiso; Josep Maria Haro; Amir Hasanzadeh; Shoaib Hassan; Soheil Hassanipour; Hadi Hassankhani; Hamid Yimam Hassen; Rasmus Havmoeller; Delia Hendrie; Fatemeh Heydarpour; Martha Híjar; Hung Chak Ho; Chi Linh Hoang; Michael K. Hole; Ramesh Holla; Naznin Hossain; Mehdi Hosseinzadeh; Sorin Hostiuc; Guoqing Hu; Segun Emmanuel Ibitoye; Olayinka Stephen Ilesanmi; Leeberk Raja Inbaraj; Seyed Sina Naghibi Irvani; M. Mofizul Islam; Sheikh Mohammed Shariful Islam; Rebecca Q. Ivers; Mohammad Ali Jahani; Mihajlo Jakovljevic; Farzad Jalilian; Sudha Jayaraman; Achala Upendra Jayatilleke; Ravi Prakash Jha; Yetunde O. John-Akinola; Jost B. Jonas; Kelly M. Jones; Nitin Joseph; Farahnaz Joukar; Jacek Jerzy Jozwiak; Suresh Banayya Jungari; Mikk Jürisson; Ali Kabir; Amaha Kahsay; Leila R. Kalankesh; Rohollah Kalhor; Teshome Abegaz Kamil; Tanuj Kanchan; Neeti Kapoor; Manoochehr Karami; Amir Kasaeian; Hagazi Gebremedhin Kassaye; Taras Kavetskyy; Gbenga A. Kayode; Peter Njenga Keiyoro; Abraham Getachew Kelbore; Yousef Saleh Khader; Morteza Abdullatif Khafaie; Nauman Khalid; Ibrahim A. Khalil; Rovshan Khalilov; Maseer Khan; Ejaz Ahmad Khan; Junaid Khan; Tripti Khanna; Salman Khazaei; Habibolah Khazaie; Roba Khundkar; Daniel N. Kiirithio; Young-Eun Kim; Yun Jin Kim; Daniel Kim; Sezer Kisa; Adnan Kisa; Hamidreza Komaki; Shivakumar K. M. Kondlahalli; Ali Koolivand; Vladimir Andreevich Korshunov; Ai Koyanagi; Moritz U. G. Kraemer; Kewal Krishan; Barthelemy Kuate Defo; Burcu Kucuk Bicer; Nuworza Kugbey; Nithin Kumar; Manasi Kumar; Vivek Kumar; Narinder Kumar; Girikumar Kumaresh; Faris Hasan Lami; Van C. Lansingh; Savita Lasrado; Arman Latifi; Paolo Lauriola; Carlo La Vecchia; Janet L. Leasher; Shaun Wen Huey Lee; Shanshan Li; Xuefeng Liu; Alan D. Lopez; Paulo A. Lotufo; Ronan A. Lyons; Daiane Borges Machado; Mohammed Madadin; Muhammed Magdy Abd El Razek; Narayan Bahadur Mahotra; Marek Majdan; Azeem Majeed; Venkatesh Maled; Deborah Carvalho Malta; Navid Manafi; Amir Manafi; Ana-Laura Manda; Narayana Manjunatha; Fariborz Mansour-Ghanaei; Mohammad Ali Mansournia; Joemer C. Maravilla; Amanda J. Mason-Jones; Seyedeh Zahra Masoumi; Benjamin Ballard Massenburg; Pallab K. Maulik; Man Mohan Mehndiratta; Zeleke Aschalew Melketsedik; Peter T. N. Memiah; Walter Mendoza; Ritesh G. Menezes; Melkamu Merid Mengesha; Tuomo J. Meretoja; Atte Meretoja; Hayimro Edemealem Merie; Tomislav Mestrovic; Bartosz Miazgowski; Tomasz Miazgowski; Ted R. Miller; G.K. Mini; Andreea Mirica; Erkin M. Mirrakhimov; Mehdi Mirzaei-Alavijeh; Prasanna Mithra; Babak Moazen; Masoud Moghadaszadeh; Efat Mohamadi; Yousef Mohammad; Aso Mohammad Darwesh; Abdollah Mohammadian-Hafshejani; Reza Mohammadpourhodki; Shafiu Mohammed; Jemal Abdu Mohammed; Farnam Mohebi; Mohammad A. Mohseni Bandpei; Mariam Molokhia; Lorenzo Monasta; Yoshan Moodley; Masoud Moradi; Ghobad Moradi; Maziar Moradi-Lakeh; Rahmatollah Moradzadeh; Lidia Morawska; Ilais Moreno Velásquez; Shane Douglas Morrison; Tilahun Belete Mossie; Atalay Goshu Muluneh; Kamarul Imran Musa; Ghulam Mustafa; Mehdi Naderi; Ahamarshan Jayaraman Nagarajan; Gurudatta Naik; Mukhammad David Naimzada; Farid Najaf; Vinay Nangia; Bruno Ramos Nascimento; Morteza Naserbakht; Vinod Nayak; Javad Nazari; Duduzile Edith Ndwandwe; Ionut Negoi; Josephine W. Ngunjiri; Trang Huyen Nguyen; Cuong Tat Nguyen; Diep Ngoc Nguyen; Huong Lan Thi Nguyen; Rajan Nikbakhsh; Dina Nur Anggraini Ningrum; Chukwudi A. Nnaji; Richard Ofori-Asenso; Felix Akpojene Ogbo; Onome Bright Oghenetega; In-Hwan Oh; Andrew T. Olagunju; Tinuke O. Olagunju; Ahmed Omar Bali; Obinna E. Onwujekwe; Heather M. Orpana; Erika Ota; Nikita Otstavnov; Stanislav S. Otstavnov; A.P. Mahesh; Jagadish Rao Padubidri; Smita Pakhale; Keyvan Pakshir; Songhomitra Panda-Jonas; Eun-Kee Park; Sangram Kishor Patel; Ashish Pathak; Sanghamitra Pati; Kebreab Paulos; Amy E. Peden; Veincent Christian Filipino Pepito; Jeevan Pereira; Michael R. Phillips; Roman V. Polibin; Suzanne Polinder; Farshad Pourmalek; Akram Pourshams; Hossein Poustchi; Swayam Prakash; Dimas Ria Angga Pribadi; Parul Puri; Zahiruddin Quazi Syed; Navid Rabiee; Mohammad Rabiee; Amir Radfar; Anwar Rafay; Ata Rafee; Alireza Rafei; Fakher Rahim; Siavash Rahimi; Muhammad Aziz Rahman; Ali Rajabpour-Sanati; Fatemeh Rajati; Ivo Rakovac; Sowmya J. Rao; Vahid Rashedi; Prateek Rastogi; Priya Rathi; Salman Rawaf; Lal Rawal; Reza Rawassizadeh; Vishnu Renjith; Serge Resnikoff; Aziz Rezapour; Ana Isabel Ribeiro; Jennifer Rickard; Carlos Miguel Rios González; Leonardo Roever; Luca Ronfani; Gholamreza Roshandel; Basema Saddik; Hamid Safarpour; Mahdi Safdarian; S. Mohammad Sajadi; Payman Salamati; Marwa R. Rashad Salem; Hosni Salem; Inbal Salz; Abdallah M. Samy; Juan Sanabria; Lidia Sanchez Riera; Milena M. Santric Milicevic; Abdur Razzaque Sarker; Arash Sarveazad; Brijesh Sathian; Monika Sawhney; Mehdi Sayyah; David C. Schwebel; Soraya Seedat; Subramanian Senthilkumaran; Seyedmojtaba Seyedmousavi; Feng Sha; Faramarz Shaahmadi; Saeed Shahabi; Masood Ali Shaikh; Mehran Shams-Beyranvand; Aziz Sheikh; Mika Shigematsu; Jae Il Shin; Rahman Shiri; Soraya Siabani; Inga Dora Sigfusdottir; Jasvinder A. Singh; Pankaj Kumar Singh; Dhirendra Narain Sinha; Amin Soheili; Joan B. Soriano; Muluken Bekele Sorrie; Ireneous N. Soyiri; Mark A. Stokes; Mu'awiyyah Babale Sufiyan; Bryan L. Sykes; Rafael Tabarés-Seisdedos; Karen M. Tabb; Biruk Wogayehu Taddele; Yonatal Mesfin Tefera; Arash Tehrani-Banihashemi; Gebretsadkan Hintsa Tekulu; Ayenew Kassie Tesema Tesema; Berhe Etsay Tesfay; Rekha Thapar; Mariya Vladimirovna Titova; Kenean Getaneh Tlaye; Hamid Reza Tohidinik; Roman Topor-Madry; Khanh Bao Tran; Bach Xuan Tran; Jaya Prasad Tripathy; Alexander C. Tsai; Aristidis Tsatsakis; Lorainne Tudor Car; Irfan Ullah; Saif Ullah; Bhaskaran Unnikrishnan; Era Upadhyay; Olalekan A. Uthman; Pascual R. Valdez; Tommi Juhani Vasankari; Yousefi Veisani; Narayanaswamy Venketasubramanian; Francesco S. Violante; Vasily Vlassov; Yasir Waheed; Yuan-Pang Wang; Taweewat Wiangkham; Haileab Fekadu Wolde; Dawit Habte Woldeyes; Temesgen Gebeyehu Wondmeneh; Adam Belay Wondmieneh; Ai-Min Wu; Grant M. A. Wyper; Rajaram Yadav; Ali Yadollahpour; Yuichiro Yano; Sanni Yaya; Vahid Yazdi-Feyzabadi; Pengpeng Ye; Paul Yip; Engida Yisma; Naohiro Yonemoto; Seok-Jun Yoon; Yoosik Youm; Mustafa Z. Younis; Zabihollah Yousef; Chuanhua Yu; Yong Yu; Telma Zahirian Moghadam; Zoubida Zaidi; Sojib Bin Zaman; Mohammad Zamani; Hamed Zandian; Fatemeh Zarei; Zhi-Jiang Zhang; Yunquan Zhang; Arash Ziapour; Sanjay Zodpey; Rakhi Dandona; Samath Dhamminda Dharmaratne; Simon I. Hay; Ali H. Mokdad; David M. Pigott; Robert C. Reiner; Theo Vos
Background: While there is a long history of measuring death and disability from injuries, modern research methods must account for the wide spectrum of disability that can occur in an injury, and must provide estimates with sufficient demographic, geographical and temporal detail to be useful for policy makers. The Global Burden of Disease (GBD) 2017 study used methods to provide highly detailed estimates of global injury burden that meet these criteria. Methods: In this study, we report and discuss the methods used in GBD 2017 for injury morbidity and mortality burden estimation. In summary, these methods included estimating cause-specific mortality for every cause of injury, and then estimating incidence for every cause of injury. Non-fatal disability for each cause is then calculated based on the probabilities of suffering from different types of bodily injury experienced. Results: GBD 2017 produced morbidity and mortality estimates for 38 causes of injury. Estimates were produced in terms of incidence, prevalence, years lived with disability, cause-specific mortality, years of life lost and disability-adjusted life-years for a 28-year period for 22 age groups, 195 countries and both sexes. Conclusions: GBD 2017 demonstrated a complex and sophisticated series of analytical steps using the largest known database of morbidity and mortality data on injuries. GBD 2017 results should be used to help inform injury prevention policy making and resource allocation. We also identify important avenues for improving injury burden estimation in the future. © Author(s) (or their employer(s)) 2020. Re-use permitted under CC B Y. Published by BMJ.
Evaluation of atmospheric precipitable water vapour distribution and trend over India
(Springer, 2024) Chander Singh Tomar; Rajeev Bhatla; Nand Lal Singh; Vivek Kumar; Pradeep Kumar Rai; Vijay Kumar Soni; Ram Kumar Giri
Integrated Precipitable Water Vapor (IPWV) wields significant influence over atmospheric processes, the climate system, and the hydrological cycle. Spatial and temporal variability characterizes water vapor distribution in the atmosphere, with equatorial regions registering elevated water vapor percentages. There are various types of instruments and methods to assess the quantity of moisture in the air. Global Navigation Satellite System (GNSS) and radiosonde techniques have been widely used to estimate IPWV in the atmosphere. European Centre for Medium-Range Weather Forecasts Re-Analysis (ERA-5) is the latest reanalysis IPWV dataset. This study aims to assess the congruence of ERA-5-derived IPWV with GNSS-derived IPWV and study the spatial and temporal variability of IPWV over Indian region. The IPWV data from 16 monitoring stations of GNSS Atmosphere Water Vapor Watch Network of the India Meteorological Department (IMD) have been compared with ERA-5 data. The IPWV data from GNSS and ERA-5 are in excellent agreement as corroborated by correlation coefficients spanning 0.97 to 1.00 and the Root Mean Square Error (RMSE) values varying between 1.5 mm and 5.6 mm. IPWV values exhibit prominent seasonal variations, with minimum values during the winter months and peak appears between June and September, aligning with warm and moist monsoon season of India. The ERA5 data from 1981 to 2020 were used to study variability and trend over Indian region. Strong positive correlations are observed between rainfall and IPWV. The results indicated IPWV trends are moistening especially over Indian landmass, the Indian Ocean, Arabian Sea and Bay of Bengal during all the seasons except winter. © The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2024.
Event based robust action for fault restrained secondary control of DC microgrid
(Institute of Electrical and Electronics Engineers Inc., 2021) Vivek Kumar; Soumya R. Mohanty
In modern power grid, dc microgrid is widely investigated to enhance their performance capabilities and operating ranges. The main issue in the operation of dc microgrid is to ensure adequate current sharing between converters, which can be achieved by droop control phenomena. Current sharing in the dc microgrid caused voltage discrepancy that needs to be compensated simultaneously with the current sharing. In this paper distributed secondary control to compensate voltage variation under converter current sharing through consensus-based sliding mode control (SMC) is proposed. Fault tolerant control is designed by formulating optimal control computation as per event triggering law. To achieve consensus control, communication graph theory is utilized to stabilizes required communication pattern between converters. Rigorous Lyapunov based stability bounds are derived to achieve event control to compensate actuator fault. Simulations are conducted to validate the feasibility and efficacy of the proposed control scheme. © 2021 IEEE
Fractional order control with super twisting observer for AC microgrid
(Institute of Electrical and Electronics Engineers Inc., 2021) Vivek Kumar; Soumya R. Mohanty; Mahitosh Banafer
In this paper, a fractional-order continuous control with a modified super twisting disturbance observer (STDO) for a microgrid (MG) is proposed. Transient accuracy under finite-time control is a challenging issue in Islanded MG with strong disturbance rejection. sliding mode control (SMC) with conventional Sliding surface design exhibits asymptotic response with chattering contamination in the control signal. If the terminal surface is used for finite-time control, singularity and chattering problem may occur. In order to achieve chattering free finite time response with no singularity problem, fractional second-order continuous control (FSCC) is proposed with STDO. In this paper, FSCC is primarily designed to improve transient response with finite-time control. Next, STDO is utilized to achieve strong robustness against disturbance with comprehensive chattering elimination by adding a fractional term. To capitalize on optimal control effort, event-triggering control is implemented. Stability proof and event trigger conditions are derived using rigorous Lyapunov based analysis. The efficacy of the proposed controller is tested under MATLAB/Simulink. © 2021 IEEE.
Functional metagenomics: A potential tool for mining of biomolecules from environmental samples
(Elsevier Inc., 2025) Vivek Kumar; Anjali Singh; Vijay Shankar Singh; Rajan Chaurasia; Mahesh Rao; Pramod Kumar Sahu; Durgesh Kumar Jaiswal
Functional metagenomics is emerging as a transformative tool for discovering biomolecules from environmental samples, offering unprecedented insights into microbial diversity and functionality. This review explores the potential of functional metagenomics to uncover novel enzymes, antibiotics, and therapeutic compounds by analyzing environmental DNA (eDNA) without the constraints of traditional culture-based methods. The vast microbial biomass in diverse ecosystems, from soil to extreme habitats, harbors a wealth of genetic resources that can be harnessed for biotechnological applications. Researchers can use modern sequencing techniques and functional screening approaches to find and characterize genes with advantageous features, such as bioremediation capacities and industrially relevant enzymes. Despite challenges in DNA extraction and host expression systems, integrating functional metagenomics with multi-omics approaches promises to enhance our understanding of microbial interactions and facilitate the development of eco-friendly bioprocesses. This review underscores the importance of functional metagenomics in expanding our repertoire of biomolecules and highlights its potential to significantly impact biotechnology and environmental sustainability. © 2025 Elsevier Inc.
Genetic divergence analysis in Indian mustard [Brassica juncea (L.) Czern & Coss.]
(Agri. Bio. Publishers, 2014) N.P. Singh; P.K. Sharma; Vivek Kumar; Vijay Kumar; V.K. Malik
Genetic diversity analysis in Indian mustard (Brassica juncea (L.) Czern & Coss.) was carried out by using Mahalanobis D2 analysis. Thirty genotypes were grouped into IV clusters for different quality characters. Cluster IV genotypes showed maximum value for plant height (185.73), number of secondary branches per plant (32.55) and days to 50% flowering (71.23). Whereas genotypes of cluster III showed maximum value for seed yield per plant (28.36 g), number of pods per plant (728.12) and chlorophyll content (3.60). Cluster recorded genotypes with lowest mean values for days to 50% flowering (54.00). Plant height contributed the maximum to the total divergence (40.5%) followed by days to maturity. The clustering pattern did not establish clear-cut relationship between genetic diversity and geographical diversity. The cultivars included in the diverse clusters can be used as promising parents for hybridization programme for obtaining high hetaeristic responses and thus better segregates in Indian mustard.
Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
(Elsevier B.V., 2020) Cristiana Abbafati; Kaja M. Abbas; Mohammad Abbasi; Mitra Abbasifard; Mohsen Abbasi-Kangevari; Hedayat Abbastabar; Foad Abd-Allah; Ahmed Abdelalim; Mohammad Abdollahi; Ibrahim Abdollahpour; Aidin Abedi; Parisa Abedi; Kedir Hussein Abegaz; Hassan Abolhassani; Akine Eshete Abosetugn; Victor Aboyans; Elissa M. Abrams; Lucas Guimarães Abreu; Michael R.M. Abrigo; Abdulaziz Khalid Abu Haimed; Ahmed Abualhasan; Eman Abu-Gharbieh; Laith Jamal Abu-Raddad; Abdelrahman I. Abushouk; Alyssa Acebedo; Ilana N. Ackerman; Maryam Adabi; Tim Adair; Abdu A. Adamu; Oladimeji M. Adebayo; Isaac Akinkunmi Adedeji; Victor Adekanmbi; Jaimie D. Adelson; Abiodun Moshood Adeoye; Olatunji O. Adetokunboh; Davoud Adham; Shailesh M. Advani; Mohsen Afarideh; Mahdi Afshari; Ashkan Afshin; Emilie E. Agardh; Gina Agarwal; Pradyumna Agasthi; Kareha M. Agesa; Mohammad Aghaali; Seyed Mohammad Kazem Aghamir; Anurag Agrawal; Tauseef Ahmad; Alireza Ahmadi; Keivan Ahmadi; Mehdi Ahmadi; Hamid Ahmadieh; Ehsan Ahmadpour; Muktar Beshir Ahmed; Budi Aji; Temesgen Yihunie Akalu; Rufus Olusola Akinyemi; Tomi Akinyemiju; Blessing Akombi; Chisom Joyqueenet Akunna; Fares Alahdab; Ziyad Al-Aly; Khurshid Alam; Noore Alam; Samiah Alam; Tahiya Alam; Fahad Mashhour Alanezi; Turki M. Alanzi; Samuel B. Albertson; Jacqueline Elizabeth Alcalde-Rabanal; Niguse Meles Alema; Biresaw Wassihun Alemu; Yihun Mulugeta Alemu; Khalid F. Alhabib; Robert Kaba Alhassan; Muhammad Ali; Saqib Ali; Gianfranco Alicandro; Mehran Alijanzadeh; Cyrus Alinia; Vahid Alipour; Hesam Alizade; Syed Mohamed Aljunid; François Alla; Peter Allebeck; Majid Abdulrahman Hamad Almadi; Ali Almasi; Amir Almasi-Hashiani; Nihad A. Almasri; Hesham M. Al-Mekhlafi; Abdulaziz M. Almulhim; Jordi Alonso; Rajaa M. Al-Raddadi; Khalid A. Altirkawi; Arwa Khalid Alumran; Nelson Alvis-Guzman; Nelson J. Alvis-Zakzuk; Azmeraw T. Amare; Bekalu Amare; Saeed Amini; Mostafa Amini-Rarani; Arya Aminorroaya; Fatemeh Amiri; Arianna Maever L. Amit; Dickson A. Amugsi; Gianna Gayle Herrera Amul; Etsay Woldu Anbesu; Robert Ancuceanu; Deanna Anderlini; Jason A. Anderson; Catalina Liliana Andrei; Tudorel Andrei; Sofia Androudi; Colin Angus; Mina Anjomshoa; Fereshteh Ansari; Iman Ansari; Alireza Ansari-Moghaddam; Ippazio Cosimo Antonazzo; Carl Abelardo T. Antonio; Catherine M. Antony; Ernoiz Antriyandarti; Davood Anvari; Razique Anwer; Seth Christopher Yaw Appiah; Jalal Arabloo; Morteza Arab-Zozani; Aleksandr Y. Aravkin; Aseb Arba Kinfe Arba; Olatunde Aremu; Filippo Ariani; Timur Aripov; Bahram Armoon; Johan Ärnlöv; Oluwaseyi Olalekan Arowosegbe; Krishna K. Aryal; Afsaneh Arzani; Malke Asaad; Mehran Asadi-Aliabadi; Ali A. Asadi-Pooya; Samaneh Asgari; Babak Asghari; Mohammad Asghari Jafarabadi; Charlie Ashbaugh; Michael Assmus; Zahra Atafar; Seyyed Shamsadin Athari; Desta Debalkie Atnafu; Maha Moh'd Wahbi Atout; Sachin R. Atre; Madhu Sudhan Atteraya; Floriane Ausloos; Marcel Ausloos; Leticia Avila-Burgos; Euripide Frinel Gbenato Arthur Avokpaho; Beatriz Paulina Ayala Quintanilla; Getinet Ayano; Martin Amogre Ayanore; Getie Lake Aynalem; Yared Asmare Aynalem; Muluken Altaye Ayza; Samad Azari; Ghasem Azarian; Zelalem Nigussie Azene; Gulrez Azhar; Peter S. Azzopardi; B.B. Darshan; Ebrahim Babaee; Alaa Badawi; Ashish D. Badiye; Mojtaba Bagherzadeh; Eleni Bagli; Mohammad Amin Bahrami; Atif Amin Baig; Mohan Bairwa; Mohammad Hossein Bakhshaei; Ahad Bakhtiari; Shankar M. Bakkannavar; Arun Balachandran; Senthilkumar Balakrishnan; Shivanthi Balalla; Shelly Balassyano; Alberto Baldasseroni; Kylie Ball; Shoshana H. Ballew; Daniela Balzi; Maciej Banach; Srikanta K. Banerjee; Palash Chandra Banik; Marlena S. Bannick; Agegnehu Bante Bante; Simachew Animen Bante; Adhanom Gebreegziabher Baraki; Miguel A. Barboza; Suzanne Lyn Barker-Collo; Till Winfried Bärnighausen; Lope H. Barrero; Celine M. Barthelemy; Lingkan Barua; Akbar Barzegar; Huda Basaleem; Quique Bassat; Sanjay Basu; Bernhard T. Baune; Mohsen Bayati; Bayisa Abdissa Baye; Gholamreza Bazmandegan; Jacob S. Becker; Neeraj Bedi; Ettore Beghi; Masoud Behzadifar; Yannick Béjot; Tariku Tesfaye Tesfaye Bekuma; Michelle L. Bell; Aminu K. Bello; Rose G. Bender; Derrick A. Bennett; Fiona B. Bennitt; Isabela M. Bensenor; Catherine P. Benziger; Kidanemaryam Berhe; Adam E. Berman; Eduardo Bernabe; Robert S. Bernstein; Gregory J. Bertolacci; Akshaya Srikanth Bhagavathula; Reshmi Bhageerathy; Neeraj Bhala; Dinesh Bhandari; Pankaj Bhardwaj; Anusha Ganapati Bhat; Krittika Bhattacharyya; Suraj Bhattarai; Zulfiqar A. Bhutta; Sadia Bibi; Molly H. Biehl; Ali Bijani; Boris Bikbov; Ver Bilano; Muhammad Shahdaat Bin Sayeed; Antonio Biondi; Binyam Minuye Birihane; Donal Bisanzio; Catherine Bisignano; Raaj Kishore Biswas; Helen Bitew; Tone Bjørge; Moses John Bockarie; Somayeh Bohlouli; Mehdi Bohluli; Hunduma Amensisa Bojia; Srinivasa Rao Bolla; Archith Boloor; Alexandra S. Boon-Dooley; Guilherme Borges; Antonio Maria Borzì; Shiva Borzouei; Dipan Bose; Cristina Bosetti; Soufiane Boufous; Rupert Bourne; Oliver J. Brady; Dejana Braithwaite; Michael Brauer; Carol Brayne; Nicholas J.K. Breitborde; Susanne Breitner; Hermann Brenner; Alexey V. Breusov; Paul Svitil Briant; Andrew M. Briggs; Andrey Nikolaevich Briko; Nikolay Ivanovich Briko; Gabrielle B. Britton; Traolach Brugha; Dana Bryazka; Rachelle Buchbinder; Blair R. Bumgarner; Katrin Burkart; Richard Thomas Burnett; Sharath Burugina Nagaraja; Reinhard Busse; Zahid A. Butt; Florentino Luciano Caetano dos Santos; Leah E. Cahill; Lucero Cahuana-Hurtado; Tianji Cai; Charlton S.K.H. Callender; Luis Alberto Cámera; Ismael R. Campos-Nonato; Julio Cesar Campuzano Rincon; Jackie Cao; Josip Car; Rosario Cárdenas; Giulia Carreras; Juan J. Carrero; Felix Carvalho; Joao Mauricio Castaldelli-Maia; Carlos A. Castañeda-Orjuela; Giulio Castelpietra; Chris D. Castle; Emma Castro; Franz Castro; Ferrán Catalá-López; Kate Causey; Christopher R. Cederroth; Kelly M. Cercy; Ester Cerin; Julian Chalek; Joht Singh Chandan; Alex R. Chang; Angela Y. Chang; Jung-Chen Chang; Kai-Lan Chang; Jaykaran Charan; Fiona J. Charlson; Vijay Kumar Chattu; Sarika Chaturvedi; Nicolas Cherbuin; Odgerel Chimed-Ochir; Ken Lee Chin; Jesus Lorenzo Chirinos-Caceres; Daniel Youngwhan Cho; Jee-Young Jasmine Choi; Hanne Christensen; Dinh-Toi Chu; Michael T. Chung; Sheng-Chia Chung; Flavia M. Cicuttini; Liliana G. Ciobanu; Massimo Cirillo; Beniamino Cislaghi; Thomas Khaled Dwayne Classen; Aaron J. Cohen; Emma L. Collins; Haley Comfort; Kelly Compton; Sara Conti; Owen R. Cooper; Barbara Corso; Paolo Angelo Cortesi; Vera Marisa Costa; Ewerton Cousin; Richard G. Cowden; Benjamin C. Cowie; Elizabeth A. Cromwell; Andrew J. Croneberger; Di H. Cross; Marita Cross; Christopher Stephen Crowe; Jessica A. Cruz; Steven Cummins; Matthew Cunningham; Saad M.A. Dahlawi; Haijiang Dai; Hancheng Dai; Albertino Antonio Moura Damasceno; Giovanni Damiani; Emanuele D'Amico; Lalit Dandona; Rakhi Dandona; Parnaz Daneshpajouhnejad; William James Dangel; Anna-Karin Danielsson; Jiregna Darega Gela; Paul I. Dargan; Aso Mohammad Darwesh; Ahmad Daryani; Jai K. Das; Rajat Das Gupta; José das Neves; Aditya Prasad Dash; Gail Davey; Claudio Alberto Dávila-Cervantes; Adrian C. Davis; Dragos Virgil Davitoiu; Kairat Davletov; Diego De Leo; Jan-Walter De Neve; Frances E. Dean; Nicole K. DeCleene; Amanda Deen; Louisa Degenhardt; Marissa DeLang; Robert Paul Dellavalle; Feleke Mekonnen Demeke; Gebre Teklemariam Demoz; Desalegn Getnet Demsie; Edgar Denova-Gutiérrez; Nebiyu Dereje Dereje; Kebede Deribe; Nikolaos Dervenis; Rupak Desai; Assefa Desalew; Getenet Ayalew Dessie; Keshab Deuba; Samath Dhamminda Dharmaratne; Govinda Prasad Dhungana; Mostafa Dianatinasab; Diana Dias da Silva; Daniel Diaz; Zahra Sadat Dibaji Forooshani; Martin Dichgans; Alireza Didarloo; Zachary V. Dingels; Ilse N. Dippenaar; M. Ashworth Dirac; Shirin Djalalinia; Hoa Thi Do; Klara Dokova; David Teye Doku; Christiane Dolecek; Andrew J. Dolgert; Fariba Dorostkar; Chirag P. Doshi; Pratik P. Doshi; Leila Doshmangir; Abdel Douiri; Matthew C. Doxey; Kerrie E. Doyle; Tim Robert Driscoll; Eleonora Dubljanin; Susanna J. Dunachie; Bruce B. Duncan; Andre Rodrigues Duraes; Arielle Wilder Eagan; Hedyeh Ebrahimi; Mohammad Ebrahimi Kalan; David Edvardsson; Andem Effiong; Joshua R. Ehrlich; Nevine El Nahas; Iman El Sayed; Maysaa El Sayed Zaki; Maha El Tantawi; Iffat Elbarazi; Islam Y. Elgendy; Hala Rashad Elhabashy; Shaimaa I. El-Jaafary; Aisha Elsharkawy; Iqbal R.F. Elyazar; Mohammad Hassan Emamian; Sophia Emmons-Bell; Holly E. Erskine; Babak Eshrati; Khalil Eskandari; Sharareh Eskandarieh; Saman Esmaeilnejad; Firooz Esmaeilzadeh; Alireza Esteghamati; Sadaf Esteghamati; Kara Estep; Arash Etemadi; Atkilt Esaiyas Etisso; Oluchi Ezekannagha; Jessica Fanzo; Tamer Farag; Mohammad Farahmand; Anwar Faraj; Emerito Jose A. Faraon; Mohammad Fareed; Roghiyeh Faridnia; Carla Sofia e Sá Farinha; Andrea Farioli; Pawan Sirwan Faris; Andre Faro; Mithila Faruque; Farshad Farzadfar; Nazir Fattahi; Ali Akbar Fazaeli; Mehdi Fazlzadeh; Valery L. Feigin; Rachel Feldman; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; Giannina Ferrara; Pietro Ferrara; Alize J. Ferrari; Manuela L. Ferreira; Garumma Tolu Feyissa; Irina Filip; Florian Fischer; James L. Fisher; Ryan Fitzgerald; Carsten Flohr; Luisa Sorio Flor; Nataliya A. Foigt; Morenike Oluwatoyin Folayan; Artem Alekseevich Fomenkov; Lisa M. Force; Carla Fornari; Masoud Foroutan; Jack T. Fox; Joel Msafiri Francis; Tahvi D. Frank; Richard Charles Franklin; Marisa Freitas; Weijia Fu; Takeshi Fukumoto; Kai Fukutaki; John E. Fuller; Nancy Fullman; João M. Furtado; Mohamed M. Gad; Abhay Motiramji Gaidhane; Emmanuela Gakidou; Natalie C. Galles; Silvano Gallus; Amiran Gamkrelidze; Alberto L. Garcia-Basteiro; William M. Gardner; Biniyam Sahiledengle Geberemariyam; Abiyu Mekonnen Gebrehiwot; Ketema Bizuwork Gebremedhin; Gebreamlak Gebremedhn Gebremeskel; Leake G. Gebremeskel; Begashaw Melaku Gebresillassie; Assefa Ayalew Ayalew Ayalew Gebreslassie; Yilma Chisha Dea Geramo; Abraham Geremew; Anna Gershberg Hayoon; Hailay Abrha Gesesew; Peter W. 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Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings: Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates. After taking into account population growth and ageing, the absolute number of DALYs has remained stable. Since 2010, the pace of decline in global age-standardised DALY rates has accelerated in age groups younger than 50 years compared with the 1990–2010 time period, with the greatest annualised rate of decline occurring in the 0–9-year age group. Six infectious diseases were among the top ten causes of DALYs in children younger than 10 years in 2019: lower respiratory infections (ranked second), diarrhoeal diseases (third), malaria (fifth), meningitis (sixth), whooping cough (ninth), and sexually transmitted infections (which, in this age group, is fully accounted for by congenital syphilis; ranked tenth). In adolescents aged 10–24 years, three injury causes were among the top causes of DALYs: road injuries (ranked first), self-harm (third), and interpersonal violence (fifth). Five of the causes that were in the top ten for ages 10–24 years were also in the top ten in the 25–49-year age group: road injuries (ranked first), HIV/AIDS (second), low back pain (fourth), headache disorders (fifth), and depressive disorders (sixth). In 2019, ischaemic heart disease and stroke were the top-ranked causes of DALYs in both the 50–74-year and 75-years-and-older age groups. Since 1990, there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries. In 2019, there were 11 countries where non-communicable disease and injury YLDs constituted more than half of all disease burden. Decreases in age-standardised DALY rates have accelerated over the past decade in countries at the lower end of the SDI range, while improvements have started to stagnate or even reverse in countries with higher SDI. Interpretation: As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and development investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy makers to anticipate these changes. The mix of universal and more geographically specific influences on health reinforces the need for regular reporting on population health in detail and by underlying cause to help decision makers to identify success stories of disease control to emulate, as well as opportunities to improve. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
(Elsevier B.V., 2020) Cristiana Abbafati; Kaja M. Abbas; Mohsen Abbasi-Kangevari; Foad Abd-Allah; Ahmed Abdelalim; Mohammad Abdollahi; Ibrahim Abdollahpour; Kedir Hussein Abegaz; Hassan Abolhassani; Victor Aboyans; Lucas Guimarães Abreu; Michael R.M. Abrigo; Ahmed Abualhasan; Laith Jamal Abu-Raddad; Abdelrahman I. Abushouk; Maryam Adabi; Victor Adekanmbi; Abiodun Moshood Adeoye; Olatunji O. Adetokunboh; Davoud Adham; Shailesh M. Advani; Ashkan Afshin; Gina Agarwal; Seyed Mohammad Kazem Aghamir; Anurag Agrawal; Tauseef Ahmad; Keivan Ahmadi; Mehdi Ahmadi; Hamid Ahmadieh; Muktar Beshir Ahmed; Temesgen Yihunie Akalu; Rufus Olusola Akinyemi; Tomi Akinyemiju; Blessing Akombi; Chisom Joyqueenet Akunna; Fares Alahdab; Ziyad Al-Aly; Khurshid Alam; Samiah Alam; Tahiya Alam; Fahad Mashhour Alanezi; Turki M. Alanzi; Biresaw Wassihun Alemu; Khalid F. Alhabib; Muhammad Ali; Saqib Ali; Gianfranco Alicandro; Cyrus Alinia; Vahid Alipour; Hesam Alizade; Syed Mohamed Aljunid; François Alla; Peter Allebeck; Amir Almasi-Hashiani; Hesham M. Al-Mekhlafi; Jordi Alonso; Khalid A. Altirkawi; Mostafa Amini-Rarani; Fatemeh Amiri; Dickson A. Amugsi; Robert Ancuceanu; Deanna Anderlini; Jason A. Anderson; Catalina Liliana Andrei; Tudorel Andrei; Colin Angus; Mina Anjomshoa; Fereshteh Ansari; Alireza Ansari-Moghaddam; Ippazio Cosimo Antonazzo; Carl Abelardo T. Antonio; Catherine M. Antony; Ernoiz Antriyandarti; Davood Anvari; Razique Anwer; Seth Christopher Yaw Appiah; Jalal Arabloo; Morteza Arab-Zozani; Aleksandr Y. Aravkin; Filippo Ariani; Bahram Armoon; Johan Ärnlöv; Afsaneh Arzani; Mehran Asadi-Aliabadi; Ali A. Asadi-Pooya; Charlie Ashbaugh; Michael Assmus; Zahra Atafar; Desta Debalkie Atnafu; Maha Moh'd Wahbi Atout; Floriane Ausloos; Marcel Ausloos; Beatriz Paulina Ayala Quintanilla; Getinet Ayano; Martin Amogre Ayanore; Samad Azari; Ghasem Azarian; Zelalem Nigussie Azene; Alaa Badawi; Ashish D. Badiye; Mohammad Amin Bahrami; Mohammad Hossein Bakhshaei; Ahad Bakhtiari; Shankar M. Bakkannavar; Alberto Baldasseroni; Kylie Ball; Shoshana H. Ballew; Daniela Balzi; Maciej Banach; Srikanta K. Banerjee; Agegnehu Bante Bante; Adhanom Gebreegziabher Baraki; Suzanne Lyn Barker-Collo; Till Winfried Bärnighausen; Lope H. Barrero; Celine M. Barthelemy; Lingkan Barua; Sanjay Basu; Bernhard T. Baune; Mohsen Bayati; Jacob S. Becker; Neeraj Bedi; Ettore Beghi; Yannick Béjot; Michelle L. Bell; Fiona B. Bennitt; Isabela M. Bensenor; Kidanemaryam Berhe; Adam E. Berman; Akshaya Srikanth Bhagavathula; Reshmi Bhageerathy; Neeraj Bhala; Dinesh Bhandari; Krittika Bhattacharyya; Zulfiqar A. Bhutta; Ali Bijani; Boris Bikbov; Muhammad Shahdaat Bin Sayeed; Antonio Biondi; Binyam Minuye Birihane; Catherine Bisignano; Raaj Kishore Biswas; Helen Bitew; Somayeh Bohlouli; Mehdi Bohluli; Alexandra S. Boon-Dooley; Guilherme Borges; Antonio Maria Borzì; Shiva Borzouei; Cristina Bosetti; Soufiane Boufous; Dejana Braithwaite; Michael Brauer; Nicholas J.K. Breitborde; Susanne Breitner; Hermann Brenner; Paul Svitil Briant; Andrey Nikolaevich Briko; Nikolay Ivanovich Briko; Gabrielle B. Britton; Dana Bryazka; Blair R. Bumgarner; Katrin Burkart; Richard Thomas Burnett; Sharath Burugina Nagaraja; Zahid A. Butt; Florentino Luciano Caetano Dos Santos; Leah E. Cahill; Luis Alberto Cámera; Ismael R. Campos-Nonato; Rosario Cárdenas; Giulia Carreras; Juan J. Carrero; Felix Carvalho; Joao Mauricio Castaldelli-Maia; Carlos A. Castañeda-Orjuela; Giulio Castelpietra; Franz Castro; Kate Causey; Christopher R. Cederroth; Kelly M. Cercy; Ester Cerin; Joht Singh Chandan; Kai-Lan Chang; Fiona J. Charlson; Vijay Kumar Chattu; Sarika Chaturvedi; Nicolas Cherbuin; Odgerel Chimed-Ochir; Daniel Youngwhan Cho; Jee-Young Jasmine Choi; Hanne Christensen; Dinh-Toi Chu; Michael T. Chung; Sheng-Chia Chung; Flavia M. Cicuttini; Liliana G. Ciobanu; Massimo Cirillo; Thomas Khaled Dwayne Classen; Aaron J. Cohen; Kelly Compton; Owen R. Cooper; Vera Marisa Costa; Ewerton Cousin; Richard G. Cowden; Di H. Cross; Jessica A. Cruz; Saad M.A. Dahlawi; Albertino Antonio Moura Damasceno; Giovanni Damiani; Lalit Dandona; Rakhi Dandona; William James Dangel; Anna-Karin Danielsson; Paul I. Dargan; Aso Mohammad Darwesh; Ahmad Daryani; Jai K. Das; Rajat Das Gupta; José das Neves; Claudio Alberto Dávila-Cervantes; Dragos Virgil Davitoiu; Diego De Leo; Louisa Degenhardt; Marissa DeLang; Robert Paul Dellavalle; Feleke Mekonnen Demeke; Gebre Teklemariam Demoz; Desalegn Getnet Demsie; Edgar Denova-Gutiérrez; Nikolaos Dervenis; Govinda Prasad Dhungana; Mostafa Dianatinasab; Diana Dias da Silva; Daniel Diaz; Zahra Sadat Dibaji Forooshani; Shirin Djalalinia; Hoa Thi Do; Klara Dokova; Fariba Dorostkar; Leila Doshmangir; Tim Robert Driscoll; Bruce B. Duncan; Andre Rodrigues Duraes; Arielle Wilder Eagan; David Edvardsson; Nevine El Nahas; Iman El Sayed; Maha El Tantawi; Iffat Elbarazi; Islam Y. Elgendy; Shaimaa I. El-Jaafary; Iqbal R.F. Elyazar; Sophia Emmons-Bell; Holly E. Erskine; Sharareh Eskandarieh; Saman Esmaeilnejad; Alireza Esteghamati; Kara Estep; Arash Etemadi; Atkilt Esaiyas Etisso; Jessica Fanzo; Mohammad Farahmand; Mohammad Fareed; Roghiyeh Faridnia; Andrea Farioli; Andre Faro; Mithila Faruque; Farshad Farzadfar; Nazir Fattahi; Mehdi Fazlzadeh; Valery L. Feigin; Rachel Feldman; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; Giannina Ferrara; Alize J. Ferrari; Manuela L. Ferreira; Irina Filip; Florian Fischer; James L. Fisher; Luisa Sorio Flor; Nataliya A. Foigt; Morenike Oluwatoyin Folayan; Artem Alekseevich Fomenkov; Lisa M. Force; Masoud Foroutan; Richard Charles Franklin; Marisa Freitas; Weijia Fu; Takeshi Fukumoto; João M. Furtado; Mohamed M. Gad; Emmanuela Gakidou; Silvano Gallus; Alberto L. Garcia-Basteiro; William M. Gardner; Biniyam Sahiledengle Geberemariyam; Assefa Ayalew Ayalew Ayalew Gebreslassie; Abraham Geremew; Anna Gershberg Hayoon; Peter W. Gething; Maryam Ghadimi; Keyghobad Ghadiri; Fatemeh Ghaffarifar; Mansour Ghafourifard; Farhad Ghamari; Ahmad Ghashghaee; Hesam Ghiasvand; Nermin Ghith; Asadollah Gholamian; Rakesh Ghosh; Paramjit Singh Gill; Themba G. Ginindza; Giorgia Giussani; Elena V. Gnedovskaya; Salime Goharinezhad; Sameer Vali Gopalani; Giuseppe Gorini; Houman Goudarzi; Alessandra C. Goulart; Felix Greaves; Michal Grivna; Giuseppe Grosso; Mohammed Ibrahim Mohialdeen Gubari; Harish Chander Gugnani; Rafael Alves Guimarães; Rashid Abdi Guled; Gaorui Guo; Yuming Guo; Rajeev Gupta; Tarun Gupta; Beatrix Haddock; Nima Hafezi-Nejad; Abdul Hafiz; Arvin Haj-Mirzaian; Arya Haj-Mirzaian; Brian J. Hall; Iman Halvaei; Randah R. Hamadeh; Samer Hamidi; Melanie S. Hammer; Graeme J. Hankey; Hamidreza Haririan; Josep Maria Haro; Ahmed I. Hasaballah; Md Mehedi Hasan; Edris Hasanpoor; Abdiwahab Hashi; Soheil Hassanipour; Hadi Hassankhani; Rasmus J. Havmoeller; Simon I. Hay; Khezar Hayat; Golnaz Heidari; Reza Heidari-Soureshjani; Hannah J. Henrikson; Molly E. Herbert; Claudiu Herteliu; Fatemeh Heydarpour; Thomas R. Hird; Hans W. Hoek; Ramesh Holla; Praveen Hoogar; H. Dean Hosgood; Naznin Hossain; Mostafa Hosseini; Mehdi Hosseinzadeh; Mihaela Hostiuc; Sorin Hostiuc; Mowafa Househ; Mohamed Hsairi; Vivian Chia-Rong Hsieh; Guoqing Hu; Kejia Hu; Tanvir M. Huda; Ayesha Humayun; Chantal K. Huynh; Bing-Fang Hwang; Vincent C. Iannucci; Segun Emmanuel Ibitoye; Nayu Ikeda; Kevin S. Ikuta; Olayinka Stephen Ilesanmi; Irena M. Ilic; Milena D. Ilic; Leeberk Raja Inbaraj; Helen Ippolito; Usman Iqbal; Seyed Sina Naghibi Irvani; Caleb Mackay Salpeter Irvine; M. Mofizul Islam; Sheikh Mohammed Shariful Islam; Hiroyasu Iso; Rebecca Q. Ivers; Chidozie C.D. Iwu; Chinwe Juliana Iwu; Ihoghosa Osamuyi Iyamu; Jalil Jaafari; Kathryn H. Jacobsen; Hussain Jafari; Morteza Jafarinia; Mohammad Ali Jahani; Mihajlo Jakovljevic; Farzad Jalilian; Spencer L. James; Hosna Janjani; Tahereh Javaheri; Javad Javidnia; Panniyammakal Jeemon; Ensiyeh Jenabi; Ravi Prakash Jha; Vivekanand Jha; John S. Ji; Lars Johansson; Oommen John; Yetunde O. John-Akinola; Catherine Owens Johnson; Jost B. Jonas; Farahnaz Joukar; Jacek Jerzy Jozwiak; Mikk Jürisson; Ali Kabir; Zubair Kabir; Hamed Kalani; Rizwan Kalani; Leila R. Kalankesh; Rohollah Kalhor; Tanuj Kanchan; Neeti Kapoor; Behzad Karami Matin; André Karch; Mohd Anisul Karim; Getachew Mullu Kassa; Srinivasa Vittal Katikireddi; Gbenga A. Kayode; Ali Kazemi Karyani; Peter Njenga Keiyoro; Cathleen Keller; Laura Kemmer; Parkes J. Kendrick; Nauman Khalid; Mohammad Khammarnia; Ejaz Ahmad Khan; Maseer Khan; Khaled Khatab; Mona M. Khater; Mahalaqua Nazli Khatib; Maryam Khayamzadeh; Salman Khazaei; Christian Kieling; Yun Jin Kim; Ruth W. Kimokoti; Adnan Kisa; Sezer Kisa; Mika Kivimäki; Luke D. Knibbs; Ann Kristin Skrindo Knudsen; Jonathan M. Kocarnik; Sonali Kochhar; Jacek A. Kopec; Vladimir Andreevich Korshunov; Parvaiz A. Koul; Ai Koyanagi; Moritz U.G. Kraemer; Kewal Krishan; Kris J. Krohn; Hans Kromhout; Barthelemy Kuate Defo; G. Anil Kumar; Vivek Kumar; Om P. Kurmi; Dian Kusuma; Carlo La Vecchia; Ben Lacey; Dharmesh Kumar Lal; Ratilal Lalloo; Tea Lallukka; Faris Hasan Lami; Iván Landires; Justin J. Lang; Sinéad M. Langan; Anders O. Larsson; Savita Lasrado; Paolo Lauriola; Jeffrey V. Lazarus; Paul H. Lee; Shaun Wen Huey Lee; Kate E. Legrand; James Leigh; Matilde Leonardi; Haley Lescinsky; Janni Leung; Miriam Levi; Shanshan Li; Lee-Ling Lim; Shai Linn; Shiwei Liu; Simin Liu; Yang Liu; Justin Lo; Alan D. Lopez; Jaifred Christian F. Lopez; Platon D. Lopukhov; Stefan Lorkowski; Paulo A. Lotufo; Alton Lu; Alessandra Lugo; Emilie R. Maddison; Phetole Walter Mahasha; Mokhtar Mahdavi Mahdavi; Morteza Mahmoudi; Azeem Majeed; Afshin Maleki; Shokofeh Maleki; Reza Malekzadeh; Deborah Carvalho Malta; Abdullah A. Mamun; Ana Laura Manda; Helena Manguerra; Fariborz Mansour-Ghanaei; Borhan Mansouri; Mohammad Ali Mansournia; Ana M. Mantilla Herrera; Joemer C. Maravilla; Ashley Marks; Randall V. Martin; Santi Martini; Francisco Rogerlândio Martins-Melo; Anthony Masaka; Seyedeh Zahra Masoumi; Manu Raj Mathur; Kunihiro Matsushita; Pallab K. Maulik; Colm McAlinden; John J. McGrath; Martin McKee; Man Mohan Mehndiratta; Fereshteh Mehri; Kala M. Mehta; Ziad A. Memish; Walter Mendoza; Ritesh G. Menezes; Endalkachew Worku Mengesha; Alibek Mereke; Seid Tiku Mereta; Atte Meretoja; Tuomo J. Meretoja; Tomislav Mestrovic; Bartosz Miazgowski; Tomasz Miazgowski; Irmina Maria Michalek; Ted R. Miller; Edward J. Mills; G.K. Mini; Mohammad Miri; Andreea Mirica; Erkin M. Mirrakhimov; Hamed Mirzaei; Maryam Mirzaei; Roya Mirzaei; Mehdi Mirzaei-Alavijeh; Awoke Temesgen Misganaw; Prasanna Mithra; Babak Moazen; Dara K. Mohammad; Yousef Mohammad; Naser Mohammad Gholi Mezerji; Abdollah Mohammadian-Hafshejani; Noushin Mohammadifard; Reza Mohammadpourhodki; Ammas Siraj Mohammed; Hussen Mohammed; Jemal Abdu Mohammed; Shafiu Mohammed; Ali H. Mokdad; Mariam Molokhia; Lorenzo Monasta; Meghan D. Mooney; Ghobad Moradi; Masoud Moradi; Maziar Moradi-Lakeh; Rahmatollah Moradzadeh; Paula Moraga; Lidia Morawska; Joana Morgado-Da-Costa; Shane Douglas Morrison; Abbas Mosapour; Jonathan F. Mosser; Simin Mouodi; Seyyed Meysam Mousavi; Amin Mousavi Khaneghah; Ulrich Otto Mueller; Satinath Mukhopadhyay; Erin C. Mullany; Kamarul Imran Musa; Saravanan Muthupandian; Ashraf F. Nabhan; Mehdi Naderi; Ahamarshan Jayaraman Nagarajan; Gabriele Nagel; Mohsen Naghavi; Behshad Naghshtabrizi; Mukhammad David Naimzada; Farid Najafi; Vinay Nangia; Jobert Richie Nansseu; Morteza Naserbakht; Vinod C. Nayak; Ionut Negoi; Josephine W. Ngunjiri; Cuong Tat Nguyen; Huong Lan Thi Nguyen; Ming Nguyen; Yeshambel T. Nigatu; Rajan Nikbakhsh; Molly R. Nixon; Chukwudi A. Nnaji; Shuhei Nomura; Bo Norrving; Jean Jacques Noubiap; Christoph Nowak; Virginia Nunez-Samudio; Bogdan Oancea; Christopher M. Odell; Felix Akpojene Ogbo; In-Hwan Oh; Emmanuel Wandera Okunga; Morteza Oladnabi; Andrew T. Olagunju; Bolajoko Olubukunola Olusanya; Jacob Olusegun Olusanya; Muktar Omer Omer; Kanyin L. Ong; Obinna E. Onwujekwe; Heather M. Orpana; Alberto Ortiz; Osayomwanbo Osarenotor; Frank B. Osei; Samuel M. Ostroff; Adrian Otoiu; Nikita Otstavnov; Stanislav S. Otstavnov; Simon Øverland; Mayowa O. Owolabi; P.A. Mahesh; Jagadish Rao Padubidri; Raffaele Palladino; Songhomitra Panda-Jonas; Anamika Pandey; Charles D. H. Parry; Maja Pasovic; Deepak Kumar Pasupula; Sangram Kishor Patel; Mona Pathak; Scott B. Patten; George C. Patton; Hamidreza Pazoki Toroudi; Amy E. Peden; Alyssa Pennini; Veincent Christian Filipino Pepito; Emmanuel K. Peprah; David M. Pereira; Konrad Pesudovs; Hai Quang Pham; Michael R. Phillips; Cristiano Piccinelli; Tessa M. Pilz; Michael A. Piradov; Meghdad Pirsaheb; Dietrich Plass; Suzanne Polinder; Kevan R. Polkinghorne; Constance Dimity Pond; Maarten J. Postma; Hadi Pourjafar; Farshad Pourmalek; Anna Poznañska; Sergio I. Prada; V. Prakash; Dimas Ria Angga Pribadi; Elisabetta Pupillo; Zahiruddin Quazi Syed; Mohammad Rabiee; Navid Rabiee; Amir Radfar; Ata Rafiee; Alberto Raggi; Muhammad Aziz Rahman; Ali Rajabpour-Sanati; Fatemeh Rajati; Ivo Rakovac; Pradhum Ram; Kiana Ramezanzadeh; Chhabi Lal Ranabhat; Puja C. Rao; Sowmya J. Rao; Vahid Rashedi; Priya Rathi; David Laith Rawaf; Salman Rawaf; Lal Rawal; Reza Rawassizadeh; Ramu Rawat; Christian Razo; Sofia Boston Redford; Robert C. Reiner; Marissa Bettay Reitsma; Giuseppe Remuzzi; Vishnu Renjith; Andre M.N. Renzaho; Serge Resnikoff; Negar Rezaei; Nima Rezaei; Aziz Rezapour; Phoebe-Anne Rhinehart; Seyed Mohammad Riahi; Daniel Cury Ribeiro; Daniela Ribeiro; Jennifer Rickard; Juan A. Rivera; Nicholas L.S. 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Background: Rigorous analysis of levels and trends in exposure to leading risk factors and quantification of their effect on human health are important to identify where public health is making progress and in which cases current efforts are inadequate. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a standardised and comprehensive assessment of the magnitude of risk factor exposure, relative risk, and attributable burden of disease. Methods: GBD 2019 estimated attributable mortality, years of life lost (YLLs), years of life lived with disability (YLDs), and disability-adjusted life-years (DALYs) for 87 risk factors and combinations of risk factors, at the global level, regionally, and for 204 countries and territories. GBD uses a hierarchical list of risk factors so that specific risk factors (eg, sodium intake), and related aggregates (eg, diet quality), are both evaluated. This method has six analytical steps. (1) We included 560 risk–outcome pairs that met criteria for convincing or probable evidence on the basis of research studies. 12 risk–outcome pairs included in GBD 2017 no longer met inclusion criteria and 47 risk–outcome pairs for risks already included in GBD 2017 were added based on new evidence. (2) Relative risks were estimated as a function of exposure based on published systematic reviews, 81 systematic reviews done for GBD 2019, and meta-regression. (3) Levels of exposure in each age-sex-location-year included in the study were estimated based on all available data sources using spatiotemporal Gaussian process regression, DisMod-MR 2.1, a Bayesian meta-regression method, or alternative methods. (4) We determined, from published trials or cohort studies, the level of exposure associated with minimum risk, called the theoretical minimum risk exposure level. (5) Attributable deaths, YLLs, YLDs, and DALYs were computed by multiplying population attributable fractions (PAFs) by the relevant outcome quantity for each age-sex-location-year. (6) PAFs and attributable burden for combinations of risk factors were estimated taking into account mediation of different risk factors through other risk factors. Across all six analytical steps, 30 652 distinct data sources were used in the analysis. Uncertainty in each step of the analysis was propagated into the final estimates of attributable burden. Exposure levels for dichotomous, polytomous, and continuous risk factors were summarised with use of the summary exposure value to facilitate comparisons over time, across location, and across risks. Because the entire time series from 1990 to 2019 has been re-estimated with use of consistent data and methods, these results supersede previously published GBD estimates of attributable burden. Findings: The largest declines in risk exposure from 2010 to 2019 were among a set of risks that are strongly linked to social and economic development, including household air pollution; unsafe water, sanitation, and handwashing; and child growth failure. Global declines also occurred for tobacco smoking and lead exposure. The largest increases in risk exposure were for ambient particulate matter pollution, drug use, high fasting plasma glucose, and high body-mass index. In 2019, the leading Level 2 risk factor globally for attributable deaths was high systolic blood pressure, which accounted for 10·8 million (95% uncertainty interval [UI] 9·51–12·1) deaths (19·2% [16·9–21·3] of all deaths in 2019), followed by tobacco (smoked, second-hand, and chewing), which accounted for 8·71 million (8·12–9·31) deaths (15·4% [14·6–16·2] of all deaths in 2019). The leading Level 2 risk factor for attributable DALYs globally in 2019 was child and maternal malnutrition, which largely affects health in the youngest age groups and accounted for 295 million (253–350) DALYs (11·6% [10·3–13·1] of all global DALYs that year). The risk factor burden varied considerably in 2019 between age groups and locations. Among children aged 0–9 years, the three leading detailed risk factors for attributable DALYs were all related to malnutrition. Iron deficiency was the leading risk factor for those aged 10–24 years, alcohol use for those aged 25–49 years, and high systolic blood pressure for those aged 50–74 years and 75 years and older. Interpretation: Overall, the record for reducing exposure to harmful risks over the past three decades is poor. Success with reducing smoking and lead exposure through regulatory policy might point the way for a stronger role for public policy on other risks in addition to continued efforts to provide information on risk factor harm to the general public. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Global injury morbidity and mortality from 1990 to 2017: Results from the global burden of disease study 2017
(BMJ Publishing Group, 2020) Spencer L. James; Chris D. Castle; Zachary V. Dingels; Jack T. Fox; Erin B. Hamilton; Zichen Liu; Nicholas L.S. Roberts; Dillon O. Sylte; Nathaniel J. Henry; Kate E. LeGrand; Ahmed Abdelalim; Amir Abdoli; Ibrahim Abdollahpour; Rizwan Suliankatchi Abdulkader; Aidin Abedi; Akine Eshete Abosetugn; Abdelrahman I. Abushouk; Oladimeji M. Adebayo; Marcela Agudelo-Botero; Tauseef Ahmad; Rushdia Ahmed; Muktar Beshir Ahmed; Miloud Taki Eddine Aichour; Fares Alahdab; Genet Melak Alamene; Fahad Mashhour Alanezi; Animut Alebel; Niguse Meles Alema; Suliman A. Alghnam; Samar Al-Hajj; Beriwan Abdulqadir Ali; Saqib Ali; Mahtab Alikhani; Cyrus Alinia; Vahid Alipour; Syed Mohamed Aljunid; Amir Almasi-Hashiani; Nihad A. Almasri; Khalid Altirkawi; Yasser Sami Abdeldayem Amer; Saeed Amini; Arianna Maever Loreche Amit; Catalina Liliana Andrei; Alireza Ansari-Moghaddam; Carl Abelardo T. Antonio; Seth Christopher Yaw Appiah; Jalal Arabloo; Morteza Arab-Zozani; Zohreh Arefi; Olatunde Aremu; Filippo Ariani; Amit Arora; Malke Asaad; Babak Asghari; Nefsu Awoke; Beatriz Paulina Ayala Quintanilla; Getinet Ayano; Martin Amogre Ayanore; Samad Azari; Ghasem Azarian; Alaa Badawi; Ashish D. Badiye; Eleni Bagli; Atif Amin Baig; Mohan Bairwa; Ahad Bakhtiari; Arun Balachandran; Maciej Banach; Srikanta K. Banerjee; Palash Chandra Banik; Amrit Banstola; Suzanne Lyn Barker-Collo; Till Winfried Bärnighausen; Lope H. Barrero; Akbar Barzegar; Mohsen Bayati; Bayisa Abdissa Baye; Neeraj Bedi; Masoud Behzadifar; Tariku Tesfaye Bekuma; Habte Belete; Corina Benjet; Derrick A. Bennett; Isabela M. Bensenor; Kidanemaryam Berhe; Pankaj Bhardwaj; Anusha Ganapati Bhat; Krittika Bhattacharyya; Sadia Bibi; Ali Bijani; Muhammad Shahdaat Bin Sayeed; Guilherme Borges; Antonio Maria Borzì; Soufiane Boufous; Alexandra Brazinova; Nikolay Ivanovich Briko; Shyam S. Budhathoki; Josip Car; Rosario Cárdenas; Félix Carvalho; João Mauricio Castaldelli-Maia; Carlos A. Castañeda-Orjuela; Giulio Castelpietra; Ferrán Catalá-López; Ester Cerin; Joht S. Chandan; Wagaye Fentahun Chanie; Soosanna Kumary Chattu; Vijay Kumar Chattu; Irini Chatziralli; Neha Chaudhary; Daniel Youngwhan Cho; Mohiuddin Ahsanul Kabir Chowdhury; Dinh-Toi Chu; Samantha M. Colquhoun; Maria-Magdalena Constantin; Vera M. Costa; Giovanni Damiani; Ahmad Daryani; Claudio Alberto Dávila-Cervantes; Feleke Mekonnen Demeke; Asmamaw Bizuneh Demis; Gebre Teklemariam Demoz; Desalegn Getnet Demsie; Afshin Derakhshani; Kebede Deribe; Rupak Desai; Mostafa Dianati Nasab; Diana Dias da Silva; Zahra Sadat Dibaji Forooshani; Kerrie E. Doyle; Tim Robert Driscoll; Eleonora Dubljanin; Bereket Duko Adema; Arielle Wilder Eagan; Aziz Eftekhari; Elham Ehsani-Chimeh; Maysaa El Sayed Zaki; Demelash Abewa Elemineh; Shaimaa I. El-Jaafary; Ziad El-Khatib; Christian Lycke Ellingsen; Mohammad Hassan Emamian; Daniel Adane Endalew; Sharareh Eskandarieh; Pawan Sirwan Faris; Andre Faro; Farshad Farzadfar; Yousef Fatahi; Wubalem Fekadu; Tomas Y. Ferede; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; Pietro Ferrara; Garumma Tolu Feyissa; Irina Filip; Florian Fischer; Morenike Oluwatoyin Folayan; Masoud Foroutan; Joel Msafiri Francis; Richard Charles Franklin; Takeshi Fukumoto; Biniyam Sahiledengle Geberemariyam; Abadi Kahsu Gebre; Ketema Bizuwork Gebremedhin; Gebreamlak Gebremedhn Gebremeskel; Berhe Gebremichael; Getnet Azeze Gedefaw; Birhanu Geta; Mansour Ghafourifard; Farhad Ghamari; Ahmad Ghashghaee; Asadollah Gholamian; Tiffany K. Gill; Alessandra C. Goulart; Ayman Grada; Michal Grivna; Mohammed Ibrahim Mohialdeen Gubari; Rafael Alves Guimarães; Yuming Guo; Gaurav Gupta; Juanita A. Haagsma; Nima Hafezi-Nejad; Hassan Haghparast Bidgoli; Brian James Hall; Randah R. Hamadeh; Samer Hamidi; Josep Maria Haro; Md Mehedi Hasan; Amir Hasanzadeh; Soheil Hassanipour; Hadi Hassankhani; Hamid Yimam Hassen; Rasmus Havmoeller; Khezar Hayat; Delia Hendrie; Fatemeh Heydarpour; Martha Híjar; Hung Chak Ho; Chi Linh Hoang; Michael K. Hole; Ramesh Holla; Naznin Hossain; Mehdi Hosseinzadeh; Sorin Hostiuc; Guoqing Hu; Segun Emmanuel Ibitoye; Olayinka Stephen Ilesanmi; Irena Ilic; Milena D. Ilic; Leeberk Raja Inbaraj; Endang Indriasih; Seyed Sina Naghibi Irvani; Sheikh Mohammed Shariful Islam; M. Mofizul Islam; Rebecca Q. Ivers; Kathryn H. Jacobsen; Mohammad Ali Jahani; Nader Jahanmehr; Mihajlo Jakovljevic; Farzad Jalilian; Sudha Jayaraman; Achala Upendra Jayatilleke; Ravi Prakash Jha; Yetunde O. John-Akinola; Jost B. Jonas; Nitin Joseph; Farahnaz Joukar; Jacek Jerzy Jozwiak; Suresh Banayya Jungari; Mikk Jürisson; Ali Kabir; Rajendra Kadel; Amaha Kahsay; Leila R. Kalankesh; Rohollah Kalhor; Teshome Abegaz Kamil; Tanuj Kanchan; Neeti Kapoor; Manoochehr Karami; Amir Kasaeian; Hagazi Gebremedhin Kassaye; Taras Kavetskyy; Hafte Kahsay Kebede; Peter Njenga Keiyoro; Abraham Getachew Kelbore; Bayew Kelkay; Yousef Saleh Khader; Morteza Abdullatif Khafaie; Nauman Khalid; Ibrahim A. Khalil; Rovshan Khalilov; Mohammad Khammarnia; Ejaz Ahmad Khan; Maseer Khan; Tripti Khanna; Habibolah Khazaie; Fatemeh Khosravi Shadmani; Roba Khundkar; Daniel N. Kiirithio; Young-Eun Kim; Daniel Kim; Yun Jin Kim; Adnan Kisa; Sezer Kisa; Hamidreza Komaki; Shivakumar K.M. Kondlahalli; Vladimir Andreevich Korshunov; Ai Koyanagi; Moritz U.G. Kraemer; Kewal Krishan; Burcu Kucuk Bicer; Nuworza Kugbey; Vivek Kumar; Nithin Kumar; G. Anil Kumar; Manasi Kumar; Girikumar Kumaresh; Om P. Kurmi; Oluwatosin Kuti; Carlo La Vecchia; Faris Hasan Lami; Prabhat Lamichhane; Justin J. Lang; Van C. Lansingh; Dennis Odai Laryea; Savita Lasrado; Arman Latifi; Paolo Lauriola; Janet L. Leasher; Shaun Wen Huey Lee; Tsegaye Lolaso Lenjebo; Miriam Levi; Shanshan Li; Shai Linn; Xuefeng Liu; Alan D. Lopez; Paulo A. Lotufo; Raimundas Lunevicius; Ronan A. Lyons; Mohammed Madadin; Muhammed Magdy Abd El Razek; Narayan Bahadur Mahotra; Marek Majdan; Azeem Majeed; Jeadran N. Malagon-Rojas; Venkatesh Maled; Reza Malekzadeh; Deborah Carvalho Malta; Navid Manafi; Amir Manafi; Ana-Laura Manda; Narayana Manjunatha; Fariborz Mansour-Ghanaei; Borhan Mansouri; Mohammad Ali Mansournia; Joemer C. Maravilla; Lyn M. March; Amanda J. Mason-Jones; Seyedeh Zahra Masoumi; Benjamin Ballard Massenburg; Pallab K. Maulik; Gebrekiros Gebremichael Meles; Addisu Melese; Zeleke Aschalew Melketsedik; Peter T.N. Memiah; Walter Mendoza; Ritesh G. Menezes; Meresa Berwo Mengesha; Melkamu Merid Mengesha; Tuomo J. Meretoja; Atte Meretoja; Hayimro Edemealem Merie; Tomislav Mestrovic; Bartosz Miazgowski; Tomasz Miazgowski; Ted R. Miller; G.K. Mini; Andreea Mirica; Erkin M. Mirrakhimov; Mehdi Mirzaei-Alavijeh; Prasanna Mithra; Babak Moazen; Masoud Moghadaszadeh; Efat Mohamadi; Yousef Mohammad; Karzan Abdulmuhsin Mohammad; Aso Mohammad Darwesh; Naser Mohammad Gholi Mezerji; Abdollah Mohammadian-Hafshejani; Milad Mohammadoo-Khorasani; Reza Mohammadpourhodki; Shafiu Mohammed; Jemal Abdu Mohammed; Farnam Mohebi; Mariam Molokhia; Lorenzo Monasta; Yoshan Moodley; Mahmood Moosazadeh; Masoud Moradi; Ghobad Moradi; Maziar Moradi-Lakeh; Farhad Moradpour; Lidia Morawska; Ilais Moreno Velásquez; Naho Morisaki; Shane Douglas Morrison; Tilahun Belete Mossie; Atalay Goshu Muluneh; Srinivas Murthy; Kamarul Imran Musa; Ghulam Mustafa; Ashraf F. Nabhan; Ahamarshan Jayaraman Nagarajan; Gurudatta Naik; Mukhammad David Naimzada; Farid Najafi; Vinay Nangia; Bruno Ramos Nascimento; Morteza Naserbakht; Vinod Nayak; Duduzile Edith Ndwandwe; Ionut Negoi; Josephine W. Ngunjiri; Cuong Tat Nguyen; Huong Lan Thi Nguyen; Rajan Nikbakhsh; Dina Nur Anggraini Ningrum; Chukwudi A. Nnaji; Peter S. Nyasulu; Felix Akpojene Ogbo; Onome Bright Oghenetega; In-Hwan Oh; Emmanuel Wandera Okunga; Andrew T. Olagunju; Tinuke O. Olagunju; Ahmed Omar Bali; Obinna E. Onwujekwe; Kwaku Oppong Asante; Heather M. Orpana; Erika Ota; Nikita Otstavnov; Stanislav S. Otstavnov; P.A. Mahesh; Jagadish Rao Padubidri; Smita Pakhale; Keyvan Pakshir; Songhomitra Panda-Jonas; Eun-Kee Park; Sangram Kishor Patel; Ashish Pathak; Sanghamitra Pati; George C. Patton; Kebreab Paulos; Amy E. Peden; Veincent Christian Filipino Pepito; Jeevan Pereira; Hai Quang Pham; Michael R. Phillips; Marina Pinheiro; Roman V. Polibin; Suzanne Polinder; Hossein Poustchi; Swayam Prakash; Dimas Ria Angga Pribadi; Parul Puri; Zahiruddin Quazi Syed; Mohammad Rabiee; Navid Rabiee; Amir Radfar; Anwar Rafay; Ata Rafiee; Alireza Rafiei; Fakher Rahim; Siavash Rahimi; Vafa Rahimi-Movaghar; Muhammad Aziz Rahman; Ali Rajabpour-Sanati; Fatemeh Rajati; Ivo Rakovac; Kavitha Ranganathan; Sowmya J. Rao; Vahid Rashedi; Prateek Rastogi; Priya Rathi; Salman Rawaf; Lal Rawal; Reza Rawassizadeh; Vishnu Renjith; Andre M.N. Renzaho; Serge Resnikoff; Aziz Rezapour; Ana Isabel Ribeiro; Jennifer Rickard; Carlos Miguel Rios González; Luca Ronfani; Gholamreza Roshandel; Anas M. Saad; Yogesh Damodar Sabde; Siamak Sabour; Basema Saddik; Saeed Safari; Roya Safari-Faramani; Hamid Safarpour; Mahdi Safdarian; S. Mohammad Sajadi; Payman Salamati; Farkhonde Salehi; Saleh Salehi Zahabi; Marwa R. Rashad Salem; Hosni Salem; Omar Salman; Inbal Salz; Abdallah M. Samy; Juan Sanabria; Lidia Sanchez Riera; Milena M. Santric Milicevic; Abdur Razzaque Sarker; Arash Sarveazad; Brijesh Sathian; Monika Sawhney; Susan M. Sawyer; Sonia Saxena; Mehdi Sayyah; David C. Schwebel; Soraya Seedat; Subramanian Senthilkumaran; Sadaf G. Sepanlou; Seyedmojtaba Seyedmousavi; Feng Sha; Faramarz Shaahmadi; Saeed Shahabi; Masood Ali Shaikh; Mehran Shams-Beyranvand; Morteza Shamsizadeh; Mahdi Sharif-Alhoseini; Hamid Sharifi; Aziz Sheikh; Mika Shigematsu; Jae Il Shin; Rahman Shiri; Soraya Siabani; Inga Dora Sigfusdottir; Pankaj Kumar Singh; Jasvinder A. Singh; Dhirendra Narain Sinha; Catalin-Gabriel Smarandache; Emma U.R. Smith; Amin Soheili; Bija Soleymani; Ali Reza Soltanian; Joan B. Soriano; Muluken Bekele Sorrie; Ireneous N. Soyiri; Dan J. Stein; Mark A. Stokes; Babale Sufiyan Mu'awiyyah; Hafiz Ansar Rasul Suleria; Bryan L. Sykes; Rafael Tabarés-Seisdedos; Karen M. Tabb; Biruk Wogayehu Taddele; Degena Bahrey Tadesse; Animut Tagele Tamiru; Ingan Ukur Tarigan; Yonatal Mesfin Tefera; Arash Tehrani-Banihashemi; Merhawi Gebremedhin Tekle; Gebretsadkan Hintsa Tekulu; Ayenew Kassie Tesema; Berhe Etsay Tesfay; Rekha Thapar; Asres Bedaso Tilahune; Kenean Getaneh Tlaye; Hamid Reza Tohidinik; Roman Topor-Madry; Bach Xuan Tran; Khanh Bao Tran; Jaya Prasad Tripathy; Alexander C. Tsai; Lorainne Tudor Car; Saif Ullah; Irfan Ullah; Maida Umar; Bhaskaran Unnikrishnan; Era Upadhyay; Olalekan A. Uthman; Pascual R. Valdez; Tommi Juhani Vasankari; Narayanaswamy Venketasubramanian; Francesco S. Violante; Vasily Vlassov; Yasir Waheed; Girmay Teklay Weldesamuel; Andrea Werdecker; Taweewat Wiangkham; Haileab Fekadu Wolde; Dawit Habte Woldeyes; Dawit Zewdu Wondafrash; Temesgen Gebeyehu Wondmeneh; Adam Belay Wondmieneh; Ai-Min Wu; Rajaram Yadav; Ali Yadollahpour; Yuichiro Yano; Sanni Yaya; Vahid Yazdi-Feyzabadi; Paul Yip; Engida Yisma; Naohiro Yonemoto; Seok-Jun Yoon; Yoosik Youm; Mustafa Z. Younis; Zabihollah Yousefi; Yong Yu; Chuanhua Yu; Hasan Yusefzadeh; Telma Zahirian Moghadam; Zoubida Zaidi; Sojib Bin Zaman; Mohammad Zamani; Maryam Zamanian; Hamed Zandian; Ahmad Zarei; Fatemeh Zare; Zhi-Jiang Zhang; Yunquan Zhang; Sanjay Zodpey; Lalit Dandona; Rakhi Dandona; Louisa Degenhardt; Samath Dhamminda Dharmaratne; Simon I. Hay; Ali H. Mokdad; Robert C. Reiner; Benn Sartorius; Theo Vos
Background Past research in population health trends has shown that injuries form a substantial burden of population health loss. Regular updates to injury burden assessments are critical. We report Global Burden of Disease (GBD) 2017 Study estimates on morbidity and mortality for all injuries. methods We reviewed results for injuries from the GBD 2017 study. GBD 2017 measured injury-specific mortality and years of life lost (YLLs) using the Cause of Death Ensemble model. To measure non-fatal injuries, GBD 2017 modelled injury-specific incidence and converted this to prevalence and years lived with disability (YLDs). YLLs and YLDs were summed to calculate disability-adjusted life years (DALYs). Findings In 1990, there were 4 260 493 (4 085 700 to 4 396 138) injury deaths, which increased to 4 484 722 (4 332 010 to 4 585 554) deaths in 2017, while age-standardised mortality decreased from 1079 (1073 to 1086) to 738 (730 to 745) per 100 000. In 1990, there were 354 064 302 (95% uncertainty interval: 338 174 876 to 371 610 802) new cases of injury globally, which increased to 520 710 288 (493 430 247 to 547 988 635) new cases in 2017. During this time, age-standardised incidence decreased non-significantly from 6824 (6534 to 7147) to 6763 (6412 to 7118) per 100 000. Between 1990 and 2017, age-standardised DALYs decreased from 4947 (4655 to 5233) per 100 000 to 3267 (3058 to 3505). Interpretation Injuries are an important cause of health loss globally, though mortality has declined between 1990 and 2017. Future research in injury burden should focus on prevention in high-burden populations, improving data collection and ensuring access to medical care. © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.
Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
(Elsevier Ltd, 2022) Rajesh Sharma; Mohsen Abbasi-Kangevari; Rami Abd-Rabu; Hassan Abidi; Eman Abu-Gharbieh; Juan Manuel Acuna; Sangeet Adhikari; Shailesh M. Advani; Muhammad Sohail Afzal; Mohamad Aghaie Meybodi; Bright Opoku Ahinkorah; Sajjad Ahmad; Ali Ahmadi; Sepideh Ahmadi; Haroon Ahmed; Luai A. Ahmed; Muktar Beshir Ahmed; Hanadi Al Hamad; Fares Alahdab; Fahad Mashhour Alanezi; Turki M. Alanzi; Fadwa Alhalaiqa Naji Alhalaiqa; Yousef Alimohamadi; Vahid Alipour; Syed Mohamed Aljunid; Motasem Alkhayyat; Sami Almustanyir; Rajaa M. Al-Raddadi; Saba Alvand; Nelson Alvis-Guzman; Saeed Amini; Robert Ancuceanu; Amir Anoushiravani; Ali Arash Anoushirvani; Alireza Ansari-Moghaddam; Jalal Arabloo; Armin Aryannejad; Mohammad Asghari Jafarabadi; Seyyed Shamsadin Athari; Floriane Ausloos; Marcel Ausloos; Atalel Fentahun Awedew; Mamaru Ayenew Awoke; Tegegn Mulatu Ayana; Sina Azadnajafabad; Hiva Azami; Mohammadreza Azangou-Khyavy; Amirhossein Azari Jafari; Ashish D. 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Renzaho; Negar Rezaei; Nima Rezaei; Saeid Rezaei; Mohsen Rezaeian; Sahba Rezazadeh-Khadem; Gholamreza Roshandel; Maha Mohamed Saber-Ayad; Bahar Saberzadeh-Ardestani; Basema Saddik; Hossein Sadeghi; Umar Saeed; Maryam Sahebazzamani; Amirhossein Sahebkar; Amir Salek Farrokhi; Amir Salimi; Hamideh Salimzadeh; Pouria Samadi; Mehrnoosh Samaei; Abdallah M. Samy; Juan Sanabria; Milena M. Santric-Milicevic; Muhammad Arif Nadeem Saqib; Arash Sarveazad; Brijesh Sathian; Maheswar Satpathy; Ione Jayce Ceola Schneider; Mario Šekerija; Sadaf G. Sepanlou; Allen Seylani; Feng Sha; Sayed Mohammad Shafiee; Zahra Shaghaghi; Saeed Shahabi; Elaheh Shaker; Maedeh Sharifian; Javad Sharifi-Rad; Sara Sheikhbahaei; Jeevan K. Shetty; Reza Shirkoohi; Parnian Shobeiri; Sudeep K. Siddappa Malleshappa; Diego Augusto Santos Silva; Guilherme Silva Julian; Achintya Dinesh Singh; Jasvinder A. Singh; Md Shahjahan Siraj; Gholam Reza Sivandzadeh; Valentin Yurievich Skryabin; Anna Aleksandrovna Skryabina; Bogdan Socea; Marco Solmi; Mohammad Sadegh Soltani-Zangbar; Suhang Song; Viktória Szerencsés; Miklós Szócska; Rafael Tabarés-Seisdedos; Elnaz Tabibian; Majid Taheri; Yasaman Taheri Abkenar; Amir Taherkhani; Iman M. Talaat; Ker-Kan Tan; Abdelghani Tbakhi; Bekele Tesfaye; Amir Tiyuri; Daniel Nigusse Tollosa; Mathilde Touvier; Bach Xuan Tran; Biruk Shalmeno Tusa; Irfan Ullah; Saif Ullah; Marco Vacante; Sahel Valadan Tahbaz; Massimiliano Veroux; Bay Vo; Theo Vos; Cong Wang; Ronny Westerman; Melat Woldemariam; Seyed Hossein Yahyazadeh Jabbari; Lin Yang; Fereshteh Yazdanpanah; Chuanhua Yu; Deniz Yuce; Ismaeel Yunusa; Vesna Zadnik; Mazyar Zahir; Iman Zare; Zhi-Jiang Zhang; Mohammad Zoladi
Background: Colorectal cancer is the third leading cause of cancer deaths worldwide. Given the recent increasing trends in colorectal cancer incidence globally, up-to-date information on the colorectal cancer burden could guide screening, early detection, and treatment strategies, and help effectively allocate resources. We examined the temporal patterns of the global, regional, and national burden of colorectal cancer and its risk factors in 204 countries and territories across the past three decades. Methods: Estimates of incidence, mortality, and disability-adjusted life years (DALYs) for colorectal cancer were generated as a part of the Global Burden of Diseases, Injuries and Risk Factors Study (GBD) 2019 by age, sex, and geographical location for the period 1990–2019. Mortality estimates were produced using the cause of death ensemble model. We also calculated DALYs attributable to risk factors that had evidence of causation with colorectal cancer. Findings: Globally, between 1990 and 2019, colorectal cancer incident cases more than doubled, from 842 098 (95% uncertainty interval [UI] 810 408–868 574) to 2·17 million (2·00–2·34), and deaths increased from 518 126 (493 682–537 877) to 1·09 million (1·02–1·15). The global age-standardised incidence rate increased from 22·2 (95% UI 21·3–23·0) per 100 000 to 26·7 (24·6–28·9) per 100 000, whereas the age-standardised mortality rate decreased from 14·3 (13·5–14·9) per 100 000 to 13·7 (12·6–14·5) per 100 000 and the age-standardised DALY rate decreased from 308·5 (294·7–320·7) per 100 000 to 295·5 (275·2–313·0) per 100 000 from 1990 through 2019. Taiwan (province of China; 62·0 [48·9–80·0] per 100 000), Monaco (60·7 [48·5–73·6] per 100 000), and Andorra (56·6 [42·8–71·9] per 100 000) had the highest age-standardised incidence rates, while Greenland (31·4 [26·0–37·1] per 100 000), Brunei (30·3 [26·6–34·1] per 100 000), and Hungary (28·6 [23·6–34·0] per 100 000) had the highest age-standardised mortality rates. From 1990 through 2019, a substantial rise in incidence rates was observed in younger adults (age <50 years), particularly in high Socio-demographic Index (SDI) countries. Globally, a diet low in milk (15·6%), smoking (13·3%), a diet low in calcium (12·9%), and alcohol use (9·9%) were the main contributors to colorectal cancer DALYs in 2019. Interpretation: The increase in incidence rates in people younger than 50 years requires vigilance from researchers, clinicians, and policy makers and a possible reconsideration of screening guidelines. The fast-rising burden in low SDI and middle SDI countries in Asia and Africa calls for colorectal cancer prevention approaches, greater awareness, and cost-effective screening and therapeutic options in these regions. Funding: Bill & Melinda Gates Foundation. © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-Adjusted life-years for 29 cancer groups, 1990 to 2017: A systematic analysis for the global burden of disease study
(American Medical Association, 2019) Christina Fitzmaurice; Degu Abate; Naghmeh Abbasi; Hedayat Abbastabar; Foad Abd-Allah; Omar Abdel-Rahman; Ahmed Abdelalim; Amir Abdoli; Ibrahim Abdollahpour; Abdishakur S. M. Abdulle; Nebiyu Dereje Abebe; Haftom Niguse Abraha; Laith Jamal Abu-Raddad; Ahmed Abualhasan; Isaac Akinkunmi Adedeji; Shailesh M. Advani; Mohsen Afarideh; Mahdi Afshari; Mohammad Aghaali; Dominic Agius; Sutapa Agrawal; Ayat Ahmadi; Elham Ahmadian; Ehsan Ahmadpour; Muktar Beshir Ahmed; Mohammad Esmaeil Akbari; Tomi Akinyemiju; Ziyad Al-Aly; Assim M. Alabdulkader; Fares Alahdab; Tahiya Alam; Genet Melak Alamene; Birhan Tamene T. Alemnew; Kefyalew Addis Alene; Cyrus Alinia; Vahid Alipour; Syed Mohamed Aljunid; Fatemeh Allah Bakeshei; Majid Abdulrahman Hamad Almadi; Amir Almasi-Hashiani; Ubai Alsharif; Shirina Alsowaidi; Nelson Alvis-Guzman; Erfan Amini; Saeed Amini; Yaw Ampem Amoako; Zohreh Anbari; Nahla Hamed Anber; Catalina Liliana Andrei; Mina Anjomshoa; Fereshteh Ansari; Ansariadi Ansariadi; Seth Christopher Yaw Appiah; Morteza Arab-Zozani; Jalal Arabloo; Zohreh Arefi; Olatunde Aremu; Habtamu Abera Areri; Al Artaman; Hamid Asayesh; Ephrem Tsegay Asfaw; Alebachew Fasil Ashagre; Reza Assadi; Bahar Ataeinia; Hagos Tasew Atalay; Zerihun Ataro; Suleman Atique; Marcel Ausloos; Leticia Avila-Burgos; Euripide F. G. A. Avokpaho; Ashish Awasthi; Nefsu Awoke; Beatriz Paulina Ayala Quintanilla; Martin Amogre Ayanore; Henok Tadesse Ayele; Ebrahim Babaee; Umar Bacha; Alaa Badawi; Mojtaba Bagherzadeh; Eleni Bagli; Senthilkuimar Balakrishnan; Abbas Balouchi; Till Winfried Barnighausen; Robert J. Battista; Masoud Behzadifar; Meysam Behzadifar; Bayu Begashaw Bekele; Yared Belete Belay; Yaschilal Muche Belayneh; Kathleen Kim Sachiko Berfield; Adugnaw Berhane; Eduardo Bernabe; Mircea Beuran; Nickhill Bhakta; Krittika Bhattacharyya; Belete Biadgo; Ali Bijani; Muhammad Shahdaat Bin Sayeed; Charles Birungi; Catherine Bisignano; Helen Bitew; Tone Bjorge; Archie Bleyer; Kassawmar Angaw Bogale; Hunduma Amensisa Bojia; Antonio M. Borzi; Cristina Bosetti; Ibrahim R. Bou-Orm; Hermann Brenner; Jerry D. Brewer; Andrey Nikolaevich Briko; Nikolay Ivanovich Briko; Maria Teresa Bustamante-Teixeira; Zahid A. Butt; Giulia Carreras; Juan J. Carrero; Felix Carvalho; Clara Castro; Franz Castro; Ferran Catala-Lopez; Ester Cerin; Yazan Chaiah; Wagaye Fentahun Chanie; Vijay Kumar Chattu; Pankaj Chaturvedi; Neelima Singh Chauhan; Mohammad Chehrazi; Peggy Pei-Chia Chiang; Tesfaye Yitna Chichiabellu; Onyema Greg Chido-Amajuoyi; Odgerel Chimed-Ochir; Jee-Young J. Choi; Devasahayam J. Christopher; Dinh-Toi Chu; Maria-Magdalena Constantin; Vera M. Costa; Emanuele Crocetti; Christopher Stephen Crowe; Maria Paula Curado; Saad M. A. Dahlawi; Giovanni Damiani; Amira Hamed Darwish; Ahmad Daryani; Jose Das Neves; Feleke Mekonnen Demeke; Asmamaw Bizuneh Demis; Birhanu Wondimeneh Demissie; Gebre Teklemariam Demoz; Edgar Denova-Gutierrez; Afshin Derakhshani; Kalkidan Solomon Deribe; Rupak Desai; Beruk Berhanu Desalegn; Melaku Desta; Subhojit Dey; Samath Dhamminda Dharmaratne; Meghnath Dhimal; Daniel Diaz; Mesfin Tadese Tadese Dinberu; Shirin Djalalinia; David Teye Doku; Thomas M. Drake; Manisha Dubey; Eleonora Dubljanin; Eyasu Ejeta Duken; Hedyeh Ebrahimi; Andem Effiong; Aziz Eftekhari; Iman El Sayed; Maysaa El Sayed Zaki; Shaimaa I. El-Jaafary; Ziad El-Khatib; Demelash Abewa Elemineh; Hajer Elkout; Richard G. Ellenbogen; Aisha Elsharkawy; Mohammad Hassan Emamian; Daniel Adane Endalew; Aman Yesuf Endries; Babak Eshrati; Ibtihal Fadhil; Vahid Fallah; Mahbobeh Faramarzi; Mahdieh Abbasalizad Farhangi; Andrea Farioli; Farshad Farzadfar; Netsanet Fentahun; Eduarda Fernandes; Garumma Tolu Feyissa; Irina Filip; Florian Fischer; James L. Fisher; Lisa M. Force; Masoud Foroutan; Marisa Freitas; Takeshi Fukumoto; Neal D. Futran; Silvano Gallus; Fortune Gbetoho Gankpe; Reta Tsegaye Gayesa; Tsegaye Tewelde Gebrehiwot; Gebreamlak Gebremedhn Gebremeskel; Getnet Azeze Gedefaw; Belayneh K. Gelaw; Birhanu Geta; Sefonias Getachew; Kebede Embaye Gezae; Mansour Ghafourifard; Alireza Ghajar; Ahmad Ghashghaee; Asadollah Gholamian; Paramjit Singh Gill; Themba T. G. Ginindza; Alem Girmay; Muluken Gizaw; Ricardo Santiago Gomez; Sameer Vali Gopalani; Giuseppe Gorini; Barbara Niegia Garcia Goulart; Ayman Grada; Maximiliano Ribeiro Guerra; Andre Luiz Sena Guimaraes; Prakash C. Gupta; Rahul Gupta; Kishor Hadkhale; Arvin Haj-Mirzaian; Arya Haj-Mirzaian; Randah R. Hamadeh; Samer Hamidi; Lolemo Kelbiso Hanfore; Josep Maria Haro; Milad Hasankhani; Amir Hasanzadeh; Hamid Yimam Hassen; Roderick J. Hay; Simon I. Hay; Andualem Henok; Nathaniel J. Henry; Claudiu Herteliu; Hagos D. Hidru; Chi Linh Hoang; Michael K. Hole; Praveen Hoogar; Nobuyuki Horita; H. Dean Hosgood; Mostafa Hosseini; Mehdi Hosseinzadeh; Mihaela Hostiuc; Sorin Hostiuc; Mowafa Househ; Mohammedaman Mama Hussen; Bogdan Ileanu; Milena D. Ilic; Kaire Innos; Seyed Sina Naghibi Irvani; Kufre Robert Iseh; Sheikh Mohammed Shariful Islam; Farhad Islami; Nader Jafari Balalami; Morteza Jafarinia; Leila Jahangiry; Mohammad Ali Jahani; Nader Jahanmehr; Mihajlo Jakovljevic; Spencer L. James; Mehdi Javanbakht; Sudha Jayaraman; Sun Ha Jee; Ensiyeh Jenabi; Ravi Prakash Jha; Jost B. Jonas; Jitendra Jonnagaddala; Tamas Joo; Suresh Banayya Jungari; Mikk Jurisson; Ali Kabir; Farin Kamangar; Andre Karch; Narges Karimi; Ansar Karimian; Amir Kasaeian; Gebremicheal Gebreslassie Kasahun; Belete Kassa; Tesfaye Dessale Kassa; Mesfin Wudu Kassaw; Anil Kaul; Peter Njenga Keiyoro; Abraham Getachew Kelbore; Amene Abebe Kerbo; Yousef Saleh Khader; Maryam Khalilarjmandi; Ejaz Ahmad Khan; Gulfaraz Khan; Young-Ho Khang; Khaled Khatab; Amir Khater; Maryam Khayamzadeh; Maryam Khazaee-Pool; Salman Khazaei; Abdullah T. Khoja; Mohammad Hossein Khosravi; Jagdish Khubchandani; Neda Kianipour; Daniel Kim; Yun Jin Kim; Adnan Kisa; Sezer Kisa; Katarzyna Kissimova-Skarbek; Hamidreza Komaki; Ai Koyanagi; Kristopher J. Krohn; Burcu Kucuk Bicer; Nuworza Kugbey; Vivek Kumar; Desmond Kuupiel; Carlo La Vecchia; Deepesh P. Lad; Eyasu Alem Lake; Ayenew Molla Lakew; Dharmesh Kumar Lal; Faris Hasan Lami; Qing Lan; Savita Lasrado; Paolo Lauriola; Jeffrey V. Lazarus; James Leigh; Cheru Tesema Leshargie; Yu Liao; Miteku Andualem Limenih; Stefan Listl; Alan D. Lopez; Platon D. Lopukhov; Raimundas Lunevicius; Mohammed Madadin; Sameh Magdeldin; Hassan Magdy Abd El Razek; Azeem Majeed; Afshin Maleki; Reza Malekzadeh; Ali Manafi; Navid Manafi; Wondimu Ayele Manamo; Morteza Mansourian; Mohammad Ali Mansournia; Lorenzo Giovanni Mantovani; Saman Maroufizadeh; Santi Martini S. Martini; Tivani Phosa Mashamba-Thompson; Benjamin Ballard Massenburg; Motswadi Titus Maswabi; Manu Raj Mathur; Colm McAlinden; Martin McKee; Hailemariam Abiy Alemu Meheretu; Ravi Mehrotra; Varshil Mehta; Toni Meier; Yohannes A. Melaku; Gebrekiros Gebremichael Meles; Hagazi Gebre Meles; Addisu Melese; Mulugeta Melku; Peter T. N. Memiah; Walter Mendoza; Ritesh G. Menezes; Shahin Merat; Tuomo J. Meretoja; Tomislav Mestrovic; Bartosz Miazgowski; Tomasz Miazgowski; Kebadnew Mulatu M. Mihretie; Ted R. Miller; Edward J. Mills; Seyed Mostafa Mir; Hamed Mirzaei; Hamid Reza Mirzaei; Rashmi Mishra; Babak Moazen; Dara K. Mohammad; Karzan Abdulmuhsin Mohammad; Yousef Mohammad; Aso Mohammad Darwesh; Abolfazl Mohammadbeigi; Hiwa Mohammadi; Moslem Mohammadi; Mahdi Mohammadian; Abdollah Mohammadian-Hafshejani; Milad Mohammadoo-Khorasani; Reza Mohammadpourhodki; Ammas Siraj Mohammed; Jemal Abdu Mohammed; Shafiu Mohammed; Farnam Mohebi; Ali H. Mokdad; Lorenzo Monasta; Yoshan Moodley; Mahmood Moosazadeh; Maryam Moossavi; Ghobad Moradi; Mohammad Moradi-Joo; Maziar Moradi-Lakeh; Farhad Moradpour; Lidia Morawska; Joana Morgado-Da-costa; Naho Morisaki; Shane Douglas Morrison; Abbas Mosapour; Seyyed Meysam Mousavi; Achenef Asmamaw Muche; Oumer Sada S. Muhammed; Jonah Musa; Ashraf R. Nabhan; Mehdi Naderi; Ahamarshan Jayaraman Nagarajan; Gabriele Nagel; Azin Nahvijou; Gurudatta Naik; Farid Najafi; Luigi Naldi; Hae Sung Nam; Naser Nasiri; Javad Nazari; Ionut Negoi; Subas Neupane; Polly A. Newcomb; Haruna Asura Nggada; Josephine W. Ngunjiri; Cuong Tat Nguyen; Leila Nikniaz; Dina Nur Anggraini Ningrum; Yirga Legesse Nirayo; Molly R. Nixon; Chukwudi A. Nnaji; Marzieh Nojomi; Shirin Nosratnejad; Malihe Nourollahpour Shiadeh; Mohammed Suleiman Obsa; Richard Ofori-Asenso; Felix Akpojene Ogbo; In-Hwan Oh; Andrew T. Olagunju; Tinuke O. Olagunju; Mojisola Morenike Oluwasanu; Abidemi E. Omonisi; Obinna E. Onwujekwe; Anu Mary Oommen; Eyal Oren; Doris D. V. Ortega-Altamirano; Erika Ota; Stanislav S. Otstavnov; Mayowa Ojo Owolabi; Mahesh P A; Jagadish Rao Padubidri; Smita Pakhale; Amir H. Pakpour; Adrian Pana; Eun-Kee Park; Hadi Parsian; Tahereh Pashaei; Shanti Patel; Snehal T. Patil; Alyssa Pennini; David M. Pereira; Cristiano Piccinelli; Julian David Pillay; Majid Pirestani; Farhad Pishgar; Maarten J. Postma; Hadi Pourjafar; Farshad Pourmalek; Akram Pourshams; Swayam Prakash; Narayan Prasad; Mostafa Qorbani; Mohammad Rabiee; Navid Rabiee; Amir Radfar; Alireza Rafiei; Fakher Rahim; Mahdi Rahimi; Muhammad Aziz Rahman; Fatemeh Rajati; Saleem M. Rana; Samira Raoofi; Goura Kishor Rath; David Laith Rawaf; Salman Rawaf; Robert C. Reiner; Andre M. N. Renzaho; Nima Rezaei; Aziz Rezapour; Ana Isabel Ribeiro; Daniela Ribeiro; Luca Ronfani; Elias Merdassa Roro; Gholamreza Roshandel; Ali Rostami; Ragy Safwat Saad; Parisa Sabbagh; Siamak Sabour; Basema Saddik; Saeid Safiri; Amirhossein Sahebkar; Mohammad Reza Salahshoor; Farkhonde Salehi; Hosni Salem; Marwa Rashad Salem; Hamideh Salimzadeh; Joshua A. Salomon; Abdallah M. Samy; Juan Sanabria; Milena M. Santric Milicevic; Benn Sartorius; Arash Sarveazad; Brijesh Sathian; Maheswar Satpathy; Miloje Savic; Monika Sawhney; Mehdi Sayyah; Ione J. C. Schneider; Ben Schottker; Mario Sekerija; Sadaf G. Sepanlou; Masood Sepehrimanesh; Seyedmojtaba Seyedmousavi; Faramarz Shaahmadi; Hosein Shabaninejad; Mohammad Shahbaz; Masood Ali Shaikh; Amir Shamshirian; Morteza Shamsizadeh; Heidar Sharafi; Zeinab Sharafi; Mehdi Sharif; Ali Sharifi; Hamid Sharifi; Rajesh Sharma; Aziz Sheikh; Reza Shirkoohi; Sharvari Rahul Shukla; Si Si; Soraya Siabani; Diego Augusto Santos Silva; Dayane Gabriele Alves Silveira; Ambrish Singh; Jasvinder A. Singh; Solomon Sisay; Freddy Sitas; Eugene Sobngwi; Moslem Soofi; Joan B. Soriano; Vasiliki Stathopoulou; Mu'awiyyah Babale Sufiyan; Rafael Tabares-Seisdedos; Takahiro Tabuchi; Ken Takahashi; Omid Reza Tamtaji; Mohammed Rasoul Tarawneh; Segen Gebremeskel Tassew; Parvaneh Taymoori; Arash Tehrani-Banihashemi; Mohamad-Hani Temsah; Omar Temsah; Berhe Etsay Tesfay; Fisaha Haile Tesfay; Manaye Yihune Teshale; Gizachew Assefa Tessema; Subash Thapa; Kenean Getaneh Tlaye; Roman Topor-Madry; Marcos Roberto Tovani-Palone; Eugenio Traini; Bach Xuan Tran; Khanh Bao Tran; Afewerki Gebremeskel Tsadik; Irfan Ullah; Olalekan A. Uthman; Marco Vacante; Maryam Vaezi; Patricia Varona Perez; Yousef Veisani; Simone Vidale; Francesco S. Violante; Vasily Vlassov; Stein Emil Vollset; Theo Vos; Kia Vosoughi; Giang Thu Vu; Isidora S. Vujcic; Henry Wabinga; Tesfahun Mulatu Wachamo; Fasil Shiferaw Wagnew; Yasir Waheed; Fitsum Weldegebreal; Girmay Teklay Weldesamuel; Tissa Wijeratne; Dawit Zewdu Wondafrash; Tewodros Eshete Wonde; Adam Belay Wondmieneh; Hailemariam Mekonnen Workie; Rajaram Yadav; Abbas Yadegar; Ali Yadollahpour; Mehdi Yaseri; Vahid Yazdi-Feyzabadi; Alex Yeshaneh; Mohammed Ahmed Yimam; Ebrahim M. Yimer; Engida Yisma; Naohiro Yonemoto; Mustafa Z. Younis; Bahman Yousefi; Mahmoud Yousefifard; Chuanhua Yu; Erfan Zabeh; Vesna Zadnik; Telma Zahirian Moghadam; Zoubida Zaidi; Mohammad Zamani; Hamed Zandian; Alireza Zangeneh; Leila Zaki; Kazem Zendehdel; Zerihun Menlkalew Zenebe; Taye Abuhay Zewale; Arash Ziapour; Sanjay Zodpey; Christopher J. L. Murray
Importance: Cancer and other noncommunicable diseases (NCDs) are now widely recognized as a threat to global development. The latest United Nations high-level meeting on NCDs reaffirmed this observation and also highlighted the slow progress in meeting the 2011 Political Declaration on the Prevention and Control of Noncommunicable Diseases and the third Sustainable Development Goal. Lack of situational analyses, priority setting, and budgeting have been identified as major obstacles in achieving these goals. All of these have in common that they require information on the local cancer epidemiology. The Global Burden of Disease (GBD) study is uniquely poised to provide these crucial data. Objective: To describe cancer burden for 29 cancer groups in 195 countries from 1990 through 2017 to provide data needed for cancer control planning. Evidence Review: We used the GBD study estimation methods to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-Adjusted life-years (DALYs). Results are presented at the national level as well as by Socio-demographic Index (SDI), a composite indicator of income, educational attainment, and total fertility rate. We also analyzed the influence of the epidemiological vs the demographic transition on cancer incidence. Findings: In 2017, there were 24.5 million incident cancer cases worldwide (16.8 million without nonmelanoma skin cancer [NMSC]) and 9.6 million cancer deaths. The majority of cancer DALYs came from years of life lost (97%), and only 3% came from years lived with disability. The odds of developing cancer were the lowest in the low SDI quintile (1 in 7) and the highest in the high SDI quintile (1 in 2) for both sexes. In 2017, the most common incident cancers in men were NMSC (4.3 million incident cases); tracheal, bronchus, and lung (TBL) cancer (1.5 million incident cases); and prostate cancer (1.3 million incident cases). The most common causes of cancer deaths and DALYs for men were TBL cancer (1.3 million deaths and 28.4 million DALYs), liver cancer (572000 deaths and 15.2 million DALYs), and stomach cancer (542000 deaths and 12.2 million DALYs). For women in 2017, the most common incident cancers were NMSC (3.3 million incident cases), breast cancer (1.9 million incident cases), and colorectal cancer (819000 incident cases). The leading causes of cancer deaths and DALYs for women were breast cancer (601000 deaths and 17.4 million DALYs), TBL cancer (596000 deaths and 12.6 million DALYs), and colorectal cancer (414000 deaths and 8.3 million DALYs). Conclusions and Relevance: The national epidemiological profiles of cancer burden in the GBD study show large heterogeneities, which are a reflection of different exposures to risk factors, economic settings, lifestyles, and access to care and screening. The GBD study can be used by policy makers and other stakeholders to develop and improve national and local cancer control in order to achieve the global targets and improve equity in cancer care. © 2019 American Medical Association. All rights reserved.
Impact of an annular solar eclipse on trace gases and meteorological parameters over Jaipur, Northwestern India
(Frontiers Media S.A., 2022) Divya Prakash; Sunita Verma; Swagata Payra; Vivek Kumar
This study aimed to identify the impact of an annular solar eclipse i.e., 21 June 2020 on the variation of meteorological parameters along with trace gases using statistical analyses. The study site is located at Poornima University, Jaipur (26.7796°N, 75.8771°E), Rajasthan, India. The observational analysis indicates a rapid decrease in solar direct radiation (SDR) which varied between 706 and 79 W/m2 during the eclipse. SDR was reduced to 79 W/m2 at the maximum peak of the solar eclipse at 11:55 a.m. at the study location. The comparative analysis shows the variation of SDR during the solar eclipse day, the previous day, and the day after the event. A strong dip was observed in SDR during the annular eclipse day concerning before (734.31 W/m2) and after (734.375 W/m2) eclipse event. Furthermore, the impact of the solar eclipse on temperature (Ts) and Relative Humidity (RH) was analyzed over Jaipur. The statistical analyses demonstrate an apparent decrease in temperature of about 2°C while RH shows a slight increment (3.45%) during the solar eclipse event. The results show an inverse correlation between the solar eclipse and trace gases variations during the eclipse due to the changes in solar radiation, surface temperature, and variation in winds that might affect the photochemical processes. Copyright © 2022 Prakash, Verma, Payra and Kumar.
Indian chronic kidney disease study: Design and methods
(Blackwell Publishing, 2017) Vivek Kumar; Ashok Kumar Yadav; Sishir Gang; Oommen John; Gopesh K. Modi; Jai Prakash Ojha; Rajendra Pandey; Sreejith Parameswaran; Narayan Prasad; Manisha Sahay; Santosh Varughese; Seema Baid-Agarwal; Vivekanand Jha
Aim: The rate and factors that influence progression of chronic kidney disease (CKD) in developing countries like India are unknown. A pan-country prospective, observational cohort study is needed to address these knowledge gaps. Methods: The Indian Chronic Kidney Disease (ICKD) study will be a cohort study of approximately 5000 patients with mild to moderate CKD presenting to centres that represent different geographical regions in India. Time to 50% decline in baseline estimated glomerular filtration rate, need of renal replacement therapy or any new cardiovascular disease (CVD) event or death from CVD are the primary end points. Value of Study: This study will provide the opportunity to determine risk factors for CKD progression and development of CVD in Indian subjects and perform international comparisons to determine ethnic and geographical differences. A bio-repository will provide a chance to discover biomarkers and explore genetic risk factors. © 2016 Asian Pacific Society of Nephrology
Leveraging machine learning for wind speed prediction in Varanasi: A Path to sustainable energy in the spiritual hub of India
(Elsevier Ltd, 2025) Mohan Narayan Gupta; Vivek Kumar; Harendra Kumar Yadav; Amit Gossai; Abhayraj Brisenia; Jahar Sarkar; Arnab Sarkar
Varanasi, a major spiritual centre in India, attracted 85,473,633 visitors in 2023, leading to a rise in electricity demand. In response, local authorities focus on renewable energy sources to enhance efficiency and reduce pollution. This study explores wind speed (WS) forecasting as a foundation for wind-based power generation to improve energy management and sustainability. Various machine learning (ML) models, including AdaBoost Regressor, Decision Tree Regressor, K-Nearest Neighbour (KNN), Recurrent Neural Network (RNN), and Long Short-Term Memory (LSTM) networks, were tested using meteorological data such as temperature, pressure, and humidity. A hybrid feature selection method was employed, combining correlation matrix, random forest importance, and mutual information. Results showed that LSTM achieved the highest accuracy, while RNN offered a good balance between accuracy and efficiency. The study also emphasises the critical role of pre-processing and feature selection in drastically improving prediction accuracy. Additionally, a techno-economic analysis was conducted to assess the economic viability of wind energy at Varanasi, analysing five wind turbines. The Suzlon S 144 turbine emerged as the most economically viable, with a payback period (PBP) of 9.3 years and a levelized cost of electricity (LCOE) of 0.0249 USD/kWh, demonstrating its potential for sustainable energy generation in the region. © 2025 Elsevier Ltd.
Mapping geographical inequalities in oral rehydration therapy coverage in low-income and middle-income countries, 2000-17
(Elsevier Ltd, 2020) Kirsten E. Wiens; Paulina A. Lindstedt; Brigette F. Blacker; Kimberly B. Johnson; Mathew M. Baumann; Lauren E. Schaeffer; Hedayat Abbastabar; Foad Abd-Allah; Ahmed Abdelalim; Ibrahim Abdollahpour; Kedir Hussein Abegaz; Ayenew Negesse Abejie; Lucas Guimarães Abreu; Michael R.M. Abrigo; Ahmed Abualhasan; Manfred Mario Kokou Accrombessi; Dilaram Acharya; Maryam Adabi; Abdu A. Adamu; Oladimeji M. Adebayo; Rufus Adesoji Adedoyin; Victor Adekanmbi; Olatunji O. Adetokunboh; Beyene Meressa Adhena; Mohsen Afarideh; Sohail Ahmad; Keivan Ahmadi; Anwar E. Ahmed; Muktar Beshir Ahmed; Rushdia Ahmed; Temesgen Yihunie Akalu; Fares Alahdab; Ziyad Al-Aly; Noore Alam; Samiah Alam; Genet Melak Alamene; Turki M. Alanzi; Jacqueline Elizabeth Alcalde-Rabanal; Beriwan Abdulqadir Ali; Mehran Alijanzadeh; Vahid Alipour; Syed Mohamed Aljunid; Ali Almasi; Amir Almasi-Hashiani; Hesham M. Al-Mekhlafi; Khalid A. Altirkawi; Nelson Alvis-Guzman; Nelson J. Alvis-Zakzuk; Saeed Amini; Arianna Maever L. Amit; Catalina Liliana Andrei; Mina Anjomshoa; Amir Anoushiravani; Fereshteh Ansari; Carl Abelardo T. Antonio; Benny Antony; Ernoiz Antriyandarti; Jalal Arabloo; Hany Mohamed Amin Aref; Olatunde Aremu; Bahram Armoon; Amit Arora; Krishna K. Aryal; Afsaneh Arzani; Mehran Asadi-Aliabadi; Hagos Tasew Atalay; Seyyed Shamsadin Athari; Seyyede Masoume Athari; Sachin R. Atre; Marcel Ausloos; Nefsu Awoke; Beatriz Paulina Ayala Quintanilla; Getinet Ayano; Martin Amogre Ayanore; Yared Asmare Aynalem; Samad Azari; Peter S. Azzopardi; Ebrahim Babaee; Tesleem Kayode Babalola; Alaa Badawi; Mohan Bairwa; Shankar M. Bakkannavar; Senthilkumar Balakrishnan; Ayele Geleto Bali; Maciej Banach; Joseph Adel Mattar Banoub; Aleksandra Barac; Till Winfried Bärnighausen; Huda Basaleem; Sanjay Basu; Vo Dinh Bay; Mohsen Bayati; Estifanos Baye; Neeraj Bedi; Mahya Beheshti; Masoud Behzadifar; Meysam Behzadifar; Bayu Begashaw Bekele; Yaschilal Muche Belayneh; Michelle L. 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Das; Rajat Das Gupta; Aditya Prasad Dash; Gail Davey; Claudio Alberto Dávila-Cervantes; Adrian C. Davis; Dragos Virgil Davitoiu; Fernando Pio De la Hoz; Asmamaw Bizuneh Demis; Dereje Bayissa Demissie; Getu Debalkie Demissie; Gebre Teklemariam Demoz; Edgar Denova-Gutiérrez; Kebede Deribe; Assefa Desalew; Aniruddha Deshpande; Samath Dhamminda Dharmaratne; Preeti Dhillon; Meghnath Dhimal; Govinda Prasad Dhungana; Daniel Diaz; Isaac Oluwafemi Dipeolu; Shirin Djalalinia; Kerrie E. Doyle; Eleonora Dubljanin; Bereket Duko; Andre Rodrigues Duraes; Mohammad Ebrahimi Kalan; Hisham Atan Edinur; Andem Effiong; Aziz Eftekhari; Nevine El Nahas; Iman El Sayed; Maysaa El Sayed Zaki; Maha El Tantawi; Teshome Bekele Elema; Hala Rashad Elhabashy; Shaimaa I. El-Jaafary; Hajer Elkout; Aisha Elsharkawy; Iqbal R.F. Elyazar; Aklilu Endalamaw; Daniel Adane Endalew; Sharareh Eskandarieh; Alireza Esteghamati; Sadaf Esteghamati; Arash Etemadi; Oluchi Ezekannagha; Mohammad Fareed; Roghiyeh Faridnia; Farshad Farzadfar; Mehdi Fazlzadeh; Valery L. Feigin; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; Irina Filip; Florian Fischer; Nataliya A. Foigt; Morenike Oluwatoyin Folayan; Masoud Foroutan; Richard Charles Franklin; Takeshi Fukumoto; Mohamed M. Gad; Reta Tsegaye Gayesa; Teshome Gebre; Ketema Bizuwork Gebremedhin; Gebreamlak Gebremedhn Gebremeskel; Hailay Abrha Gesesew; Kebede Embaye Gezae; Keyghobad Ghadiri; Ahmad Ghashghaee; Pramesh Raj Ghimire; Paramjit Singh Gill; Tiffany K. Gill; Themba G. Ginindza; Nelson G.M. Gomes; Sameer Vali Gopalani; Alessandra C. Goulart; Bárbara Niegia Garcia Goulart; Ayman Grada; Mohammed Ibrahim Mohialdeen Gubari; Harish Chander Gugnani; Davide Guido; Rafael Alves Guimarães; Yuming Guo; Rajeev Gupta; Nima Hafezi-Nejad; Dessalegn H. 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Background: Oral rehydration solution (ORS) is a form of oral rehydration therapy (ORT) for diarrhoea that has the potential to drastically reduce child mortality; yet, according to UNICEF estimates, less than half of children younger than 5 years with diarrhoea in low-income and middle-income countries (LMICs) received ORS in 2016. A variety of recommended home fluids (RHF) exist as alternative forms of ORT; however, it is unclear whether RHF prevent child mortality. Previous studies have shown considerable variation between countries in ORS and RHF use, but subnational variation is unknown. This study aims to produce high-resolution geospatial estimates of relative and absolute coverage of ORS, RHF, and ORT (use of either ORS or RHF) in LMICs. Methods: We used a Bayesian geostatistical model including 15 spatial covariates and data from 385 household surveys across 94 LMICs to estimate annual proportions of children younger than 5 years of age with diarrhoea who received ORS or RHF (or both) on continuous continent-wide surfaces in 2000–17, and aggregated results to policy-relevant administrative units. Additionally, we analysed geographical inequality in coverage across administrative units and estimated the number of diarrhoeal deaths averted by increased coverage over the study period. Uncertainty in the mean coverage estimates was calculated by taking 250 draws from the posterior joint distribution of the model and creating uncertainty intervals (UIs) with the 2·5th and 97·5th percentiles of those 250 draws. Findings: While ORS use among children with diarrhoea increased in some countries from 2000 to 2017, coverage remained below 50% in the majority (62·6%; 12 417 of 19 823) of second administrative-level units and an estimated 6 519 000 children (95% UI 5 254 000–7 733 000) with diarrhoea were not treated with any form of ORT in 2017. Increases in ORS use corresponded with declines in RHF in many locations, resulting in relatively constant overall ORT coverage from 2000 to 2017. Although ORS was uniformly distributed subnationally in some countries, within-country geographical inequalities persisted in others; 11 countries had at least a 50% difference in one of their units compared with the country mean. Increases in ORS use over time were correlated with declines in RHF use and in diarrhoeal mortality in many locations, and an estimated 52 230 diarrhoeal deaths (36 910–68 860) were averted by scaling up of ORS coverage between 2000 and 2017. Finally, we identified key subnational areas in Colombia, Nigeria, and Sudan as examples of where diarrhoeal mortality remains higher than average, while ORS coverage remains lower than average. Interpretation: To our knowledge, this study is the first to produce and map subnational estimates of ORS, RHF, and ORT coverage and attributable child diarrhoeal deaths across LMICs from 2000 to 2017, allowing for tracking progress over time. Our novel results, combined with detailed subnational estimates of diarrhoeal morbidity and mortality, can support subnational needs assessments aimed at furthering policy makers' understanding of within-country disparities. Over 50 years after the discovery that led to this simple, cheap, and life-saving therapy, large gains in reducing mortality could still be made by reducing geographical inequalities in ORS coverage. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license