Browsing by Author "Y.V. Rao"

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Antiinflammatory and antiulcer effects of Kaempferol, a flavone, isolated from Rhamnus procumbens
(1988) R.K. Goel; V.B. Pandey; S.P.D. Dwivedi; Y.V. Rao
[No abstract available]
Effect of centrally administered monoaminergic & cholinergic receptor antagonists on carrageenin-induced pedal edema in rats
(1982) N. Das; Y.V. Rao; P.K. Das; S.K. Bhattacharya
The effect of centrally administered monoaminergic, cholinergic and histaminergic blocking agents in doses devoid of any peripheral effect was noted on carrageenin-induced pedal edema in rats. Carrageenin edema was of short duration and the degree and time course of inflammation induced by a second injection of the phlogistic agent, administered into the contralateral paw six days later, were not significantly different from that induced by the first injection. Cannulation of the lateral cerebral ventricle and administration of artificial cerebrospinal fluid themselves reduced the edema. Pretreatment with methysergide, phentolamine or propranolol significantly attenuated carrageenin edema whereas atropine and mepyramine accentuated the inflammatory response. Haloperidol had no significant effect. The effects of these drugs were confirmed in self-control rats, using the contralateral paw, a week later. The results indicate that the central nervous system may exert a modulatory effect on peripheral inflammation through (a) hitherto unresolved mechanism(s).
Effect of pentobarbitone on body temperature and sleeping time in albino rats
(1980) Y.V. Rao; S.B. Acharya; A.K. Sanyal
Pentobarbitone sodium (PB), chloralose and urethane produced significant hypothermia and hypnosis in albino rats. PB-induced hypothermia and sleeping time were dose dependent. The hypothermic response of PB at low ambient temperatures was converted to biphasic and hyperthermic responses at 30 ± 1°C and 36± 1°C respectively. PB-induced sleeping time was not modified by different ambient temperatures. Tolerance to both hypothermia and sleeping time developed with PB by 2nd day. While PB-induced hypothermia did not register any difference between the two sexes, sleeping time was longer in females. The results thus suggest that temperature changes and consciousness are not interrelated and are probably the two different functions of the brain.
Flavonoids of Rhamnus procumbens and pharmacological actions of kaempferol-4'-O-methyl ether
(1990) V.B. Pandey; S.P.D. Dwivedi; Y.V. Rao; R.K. Goel
[No abstract available]
Intestinal ulcerogemic activity of some non steroidal antiinflammatory agents
(1981) S.B. Acharya; Y.V. Rao; P.K. Debnath; A.K. Sanyal
Several antiinflammatory agents were studied for their intestinal ulcerogenic effects in rats employing the method of Ezer and Szporny (1975). Each drug was administered orally for 3 days. The intestinal tensile strength was significantly decreased by indomethacin (IND, 10 mg/kg), diclofenac sodium (DS, 15 mg/kg) and sodium salicylate (SS, 10 mg/kg). IND induced decreased intestinal tensile strength was reversed by SS (100 mg/kg), aspirin (ASP, 300 mg/kg), hydrocortisone (HC, 20 mg/kg) and 15(S), 15 methyl PGF2α (MPGF, 400 μg/kg). SS could only partly protect IND induced decreased intestinal strength in adrenalectomised and metyrapone treated rats. DS response was potentiated by SS, ASP, and paracetamol (PCM, 100 mg/kg). HC did not significantly affect DS induced decreased intestinal tensile strength while MPGF protected it. The data of the present study cannot explain the mechanism of the ulcerogenic effect of IND and DS. © 1981 The Italian Pharmacological Society.
Isolation and pharmacological action of heliotrine, the major alkaloid of Heliotropium indicum seeds
(1982) V.B. Pandey; J.P. Singh; Y.V. Rao; S.B. Acharya
[No abstract available]
Isolation of amentoflavone from selaginella rupestris and its pharmacological activity on central nervous System, smooth muscles and isolated frog heart preparations
(1981) B.K. Chakravarthy; Y.V. Rao; S.S. Gambhir; K.D. Gode
[No abstract available]
Possible role of brain monoamines in pentobarbitone induced hypothermia in albino rats
(1982) Y.V. Rao; S.B. Acharya; A.K. Sanyal
The role of brain monoamines on the thermoregulatory effect of pentobarbitone (PB) was studied on inbred albino rats by drug interaction studies. After recording basal rectal temperature for 30 min at 10 min intervals, PB was administered (35 mg/kg, ip) r315w1.r316w1 =1,4-dihydroxy-5,8-{[2-(2-hydroxyethyl)amino]ethylamino}- 9,10-anthracenedione and thereafter temperature was recorded for 4 hr at 10 min intervals. PB produced significant hypothermia which was not sex dependent. Pretreatment with several pharmacological agents that modify the activities of brain monoamines in diverse ways, suggested that PB-induced hypothermia was attenuated when activity of either 5-hydroxytryptamine (5-HT), noradrenaline (NA) or dopamine (DA) was diminished, and hypothermia was enhanced when activity of either of these 3 amines increased. Recovery of temperature after attainment of maximal hypothermia was augmented with decreased 5-HT and delayed with enhanced 5-HT activity. The results suggest that while hypothermic response of PB is probably 5-HT, NA and DA mediated, its duration is dependent on the tryptaminergic activity in the brain.