Scholarly Publications

Permanent URI for this communityhttps://dl.bhu.ac.in/bhuir/handle/123456789/16335

This community showcases the academic contributions of faculty and researchers at Banaras Hindu University (BHU) and provides a year-wise compilation of publications across disciplines. Institutional Repository BHU

Browse

Now showing 1 - 20 of 60

A comparative analysis of phytochemicals versus synthetic drugs/nanomedicines in the treatment of uterine fibroid: a systematic review
(Korean Society of Environmental Risk Assessment and Health Science, 2024) Sonal Upadhyay; Vivek Pandey; Anima Tripathi; Alakh N. Sahu; Anjali Rani; Amita Diwakar; Lavina Chaubey; Rashmi Gupta; Pawan K. Dubey
Most women experience uterine fibroids (UFs), a common benign gynecological tumor, at some point in their reproductive age. There are several pharmacological treatments available to shrink fibroids and lessen the UF symptoms. These medications cost a lot of money, though, and frequently have serious side effects. Therefore, due to their low cost, comparable and powerful therapeutic efficiency and lower side effects, phytochemical-based medications are gaining popularity in these days. This review's goal is to provide a summary of the knowledge that is currently unavailable regarding the mechanisms of the action of various phytochemical-based medications with anti-uterine fibroid efficacy. The present results showed that dietary phytocompounds (dehydroxyelephantopin, butein, capsaicin, fisetin, kaempferol, resveratrol, silibinin and curcumin) could probably be effective as therapeutic compounds for uterine leiomyoma. These phytochemicals indicated their capability to regulate main fibroid promoting and initiating events for instance, proliferation, inflammation, angiogenesis and fibrosis in various experimental setups through modulating various signaling pathways, such as Smad 2/3, PI3K/AKT/mTOR, ERK 1/2 and β-catenin indicating that they could serve as targets for prevention and/or treatment of UFs. This review provides key molecular insights for the development of phytochemical-based novel personalized therapy for non-surgical management of UFs which may help to avoid hysterectomy. © The Author(s), under exclusive licence to Korean Society of Environmental Risk Assessment and Health Science 2023.
A shift from significance test to hypothesis test through power analysis in medical research
(2006) G. Singh
Medical research literature until recently, exhibited substantial dominance of the Fisher's significance test approach of statistical inference concentrating more on probability of type I error over Neyman-Pearson's hypothesis test considering both probability of type I and II error. Fisher's approach dichotomises results into significant or not significant results with a P value. The Neyman-Pearson's approach talks of acceptance or rejection of null hypothesis. Based on the same theory these two approaches deal with same objective and conclude in their own way. The advancement in computing techniques and availability of statistical software have resulted in increasing application of power calculations in medical research and thereby reporting the result of significance tests in the light of power of the test also. Significance test approach, when it incorporates power analysis contains the essence of hypothesis test approach. It may be safely argued that rising application of power analysis in medical research may have initiated a shift from Fisher's significance test to Neyman-Pearson's hypothesis test procedure.
Acquisition and homeostasis of Iron in higher plants and their probable role in abiotic stress tolerance
(Frontiers Media S.A., 2018) Durgesh K. Tripathi; Shweta Singh; Shweta Gaur; Swati Singh; Vaishali Yadav; Shiliang Liu; Vijay P. Singh; Shivesh Sharma; Prateek Srivastava; Sheo M. Prasad; Nawal K. Dubey; Devendra K. Chauhan; Shivendra Sahi
Iron (Fe) is a micronutrient that plays an important role in agriculture worldwide because plants require a small amount of iron for its growth and development. All major functions in a plant's life from chlorophyll biosynthesis to energy transfer are performed by Fe (Brumbarova et al., 2008; Gill and Tuteja, 2011). Iron also acts as a major constituent of many plant proteins and enzymes. The acquisition of Fe in plants occurs through two strategies, i.e., strategy I and strategy II (Marschner and Römheld, 1994). Under various stress conditions, Nramp and the YSL gene families help in translocation of Fe, which further acts as a mineral regulatory element and defends plants against stresses. Iron plays an irreplaceable role in alleviating stress imposed by salinity, drought, and heavy metal stress. This is because it activates plant enzymatic antioxidants like catalase (CAT), peroxidase, and an isoform of superoxide dismutase (SOD) that act as a scavenger of reactive oxygen species (ROS) (Hellin et al., 1995). In addition to this, their deficiency as well as their excess amount can disturb the homeostasis of a plant's cell and result in declining of photosynthetic rate, respiration, and increased accumulation of Na+ and Ca- ions which culminate in an excessive formation of ROS. The short-range order hydrated Fe oxides and organic functional groups show affinities for metal ions. Iron plaque biofilm matrices could sequester a large amount of metals at the soil-root interface. Hence, it has attracted the attention of plant physiologists and agricultural scientists who are discovering more exciting and hidden applications of Fe and its potential in the development of bio-factories. This review looks into the recent progress made in putting forward the role of Fe in plant growth, development, and acclimation under major abiotic stresses, i.e., salinity, drought, and heavy metals. © 2018 Tripathi, Singh, Gaur, Singh, Yadav, Liu, Singh, Sharma, Srivastava, Prasad, Dubey, Chauhan and Sahi.
Adrenergic beta-blockers in ophthalmology
(1990) S.K. Bhattacharya; S.B. Acharya
[No abstract available]
Adverse drug interactions
(1993) S.K. Bhattacharya
[No abstract available]
Agriculture and India today
(2007) Panjab Singh
Attainment of food security has been the major objective of India since independence. Today India is second largest producer of food in world and has all the potential of becoming world leader if the emerging problems of agriculture are addressed through technological development, appropriate policy interventions that improve farm profitability vis-à-vis agricultural sustainability. This can be done through a transition from commodity agriculture to product agriculture, that is from quantity to quality agriculture. Efforts to develop and expand new types and uses of bulk agricultural products (value addition), alternative production technology (organic and conservation agriculture) and speciality crops will create opportunities for improving economic viability of agriculture and rural communities. Value-added cooperatives that can develop new alliances with consumers (farmer-grocer contacts, internet marketing) may create new entrepreneurial opportunities in Indian agriculture. Emphasis on access to higher education and imbibition of quality and relevance in education with appropriate policy intervention will pave the ways for faster and sustainable development.
An in-depth and insightful exploration of failure detection in distributed systems
(Elsevier B.V., 2024) Bhavana Chaurasia; Anshul Verma; Pradeepika Verma
In today's world, everyone wants a good profit with a tiny investment and distributed computing is a boon for this purpose. Cloud computing, fog computing, and the Internet of Things (IoT) are well-known examples of distributed computing which provide good computing services and performance. However, providing reliable services in a real environment, which is failure-prone, remains a challenge. To address this issue, failure detectors are used in distributed systems, which are abstract modules responsible for detecting and monitoring the activity of nodes in order to determine whether they are faulty or not. In this paper, an approach is presented for the systematic literature review of failure detectors in distributed systems. Further, many existing review and survey papers on failure detectors are critically analyzed along with their key contributions and limitations. The classification of distributed systems is presented on the basis of the nodes’ properties and the components of system models are described in detail. Various issues and challenges related to agreement and failure problems are also explored. The strengths and limitations of various existing failure detectors are discussed along with their comparative evaluation. Finally, fault-tolerance and recovery techniques are discussed and analyzed. © 2024 Elsevier B.V.
Analgesics: New vistas
(1997) A. Chakrabarti; R. Tandon; S.K. Bhattacharya
[No abstract available]
Anti-stress agents from natural origin
(Natural Remedies Private Limited, 2002) P. Padma; R.L. Khosa
An exponential rise in world population coupled with rapid industrial growth has a direct impact on environment and society thus making man easily vulnerable to stress conditions. These, in-turn, cause disturbances in the normal physiological functioning of the body by way of increased free radical generation culminating in hypertension, neurosis, immune suppression and other physical and mental disorders. Global search is on, for the development of an effective antistress drug from natural source which could effectively tone up the disturbed physiological functioning of the subjects affected by such stress problems. A number of such drugs mostly in the form of their extracts (holistic approach) or in some, as active principles isolated from them, have been evaluated for their antistress activity by a number of tests which include open field behaviour; Y-maze; Swimming endurance; effect on hexobarbitone sleeping time; stress induced ulceration; monitoring corticosterone, Ascorbic acid, MAO, SOD, SDH and neurotransmitter levels in tissues/blood and others. Withania somnifera, Ocimum sanctum, Mikania cordata, Tinospora cordifolia, Centella asiatica, Panax ginseng, Glycerrhiza glabra, Annona muricata, Polyalthea cerasoides and many others have been reported with encouraging results.
Artificial blood
(Medknow Publications and Media Pvt. Ltd, 2008) Suman Sarkar
Artificial blood is a product made to act as a substitute for red blood cells. While true blood serves many different functions, artificial blood is designed for the sole purpose of transporting oxygen and carbon dioxide throughout the body. Depending on the type of artificial blood, it can be produced in different ways using synthetic production, chemical isolation, or recombinant biochemical technology. Development of the first blood substitutes dates back to the early 1600s, and the search for the ideal blood substitute continues. Various manufacturers have products in clinical trials; however, no truly safe and effective artificial blood product is currently marketed. It is anticipated that when an artificial blood product is available, it will have annual sales of over $7.6 billion in the United States alone.
Biosynthesized nanoparticles: a novel approach for cancer therapeutics
(Frontiers Media SA, 2023) Vivek K. Chaturvedi; Bhaskar Sharma; Abhay Dev Tripathi; Dawesh P. Yadav; Kshitij RB Singh; Jay Singh; Ravindra Pratap Singh
Nanotechnology has become one of the most rapid, innovative, and adaptable sciences in modern science and cancer therapy. Traditional chemotherapy has limits owing to its non-specific nature and adverse side effects on healthy cells, and it remains a serious worldwide health issue. Because of their capacity to specifically target cancer cells and deliver therapeutic chemicals directly to them, nanoparticles have emerged as a viable strategy for cancer therapies. Nanomaterials disclose novel properties based on size, distribution, and shape. Biosynthesized or biogenic nanoparticles are a novel technique with anti-cancer capabilities, such as triggering apoptosis in cancer cells and slowing tumour growth. They may be configured to deliver medications or other therapies to specific cancer cells or tumour markers. Despite their potential, biosynthesized nanoparticles confront development obstacles such as a lack of standardisation in their synthesis and characterization, the possibility of toxicity, and their efficiency against various forms of cancer. The effectiveness and safety of biosynthesized nanoparticles must be further investigated, as well as the types of cancer they are most successful against. This review discusses the promise of biosynthesized nanoparticles as a novel approach for cancer therapeutics, as well as their mode of action and present barriers to their development. 2023 Chaturvedi, Sharma, Tripathi, Yadav, Singh, Singh and Singh.
Cleavage of cell junction proteins as a host invasion strategy in leptospirosis
(Springer Science and Business Media Deutschland GmbH, 2024) Preeti Kumari; Suhani Yadav; Sresha Sarkar; Padikara K. Satheeshkumar
Abstract: Infection and invasion are the prerequisites for developing the disease symptoms in a host. While the probable mechanism of host invasion and pathogenesis is known in many pathogens, very little information is available on Leptospira invasion/pathogenesis. For causing systemic infection Leptospira must transmigrate across epithelial barriers, which is the most critical and challenging step. Extracellular and membrane-bound proteases play a crucial role in the invasion process. An extensive search for the proteins experimentally proven to be involved in the invasion process through cell junction cleavage in other pathogens has resulted in identifying 26 proteins. The similarity searches on the Leptospira genome for counterparts of these 26 pathogenesis-related proteins identified at least 12 probable coding sequences. The proteins were either extracellular or membrane-bound with a proteolytic domain to cleave the cell junction proteins. This review will emphasize our current understanding of the pathogenic aspects of host cell junction-pathogenic protein interactions involved in the invasion process. Further, potential candidate proteins with cell junction cleavage properties that may be exploited in the diagnostic/therapeutic aspects of leptospirosis will also be discussed. Key points: • The review focussed on the cell junction cleavage proteins in bacterial pathogenesis • Cell junction disruptors from Leptospira genome are identified using bioinformatics • The review provides insights into the therapeutic/diagnostic interventions possible © 2024, The Author(s).
Coating with Microbial Hydrophobins: A Novel Approach to Develop Smart Drug Nanoparticles
(Elsevier Ltd, 2018) Brahma N. Singh; Braj R. Singh; Vijai K. Gupta; Ravindra N. Kharwar; Lorenzo Pecoraro
Microbial hydrophobin (MH)-based surface coating is emerging as a novel protein engineering approach for drug nanoparticles to enhance the solubility and stability of therapeutic agents. These hydrophobins are amphiphilic proteins that can form self-assembled monolayers on hydrophobic materials and can coat nanoparticles for efficient drug delivery. © 2018 Elsevier Ltd
Combinatorial chemistry: A novel method in drug discovery and its application
(2005) S.N. Pandeya; D. Thakkar
Combinatorial chemistry is a new technique developed in pharmaceutical industry, which involves synthesis of compounds in mass instead of a single compound, which are screened as a whole mixture for particular biological activity. Because of the rapid synthesis of compounds, this method saves the time and cost associated with the drug discovery. This brief review article includes combinatorial strategies, screening methods and encoding technologies and some of the applications in drug discovery.
Constituents of Petunia nyctaginiflora
(1995) M. Singh; A.K. Singh; M. Sahai; Y. Fujimoto
[No abstract available]
COVID-19: The Cause of the Manifested Cardiovascular Complications During the Pandemic
(Frontiers Media SA, 2021) Audditiya Bandopadhyay; Alok Kumar Singh; Gyaneshwer Chaubey
In the course of human history, we encountered several devastating waves of pandemics, affecting millions of lives globally and now the rapid and progressive spread of the novel SARS-CoV-2, causing Coronavirus disease (COVID-19) has created a worldwide wave of crisis. Profoundly straining national health care systems, it also significantly impacted the global economic stability. With the introduction of COVID-19 measures, mainly driven by immunization drives, casualties due to the virus were reported to decrease considerably. But then comes into play the post-Covid morbidities, along with their short and long-term effects on the elderly and the co-morbid population. Moreover, the pediatric population and the otherwise healthy cohort of the young athletes were also reported being largely affected by the varying amount of post-recovery virus-induced Cardiac manifestations, in the subsequent waves of the pandemic. Therefore, here we thrived to find answers to the seemingly unending series of questions that popped up with the advent of the disease, nevertheless, there still lies a blind spot in understanding the impacts of the disease on the Cardiovascular Health of an individual, even after the clinical recovery. Thus, along with the current data related to the diverse cardiovascular complications due to SARS-COV-2 infection, we suggest long-term ‘Cardiac surveillance' for the COVID-19 recovered individuals. Copyright © 2021 Bandopadhyay, Singh and Chaubey.
Criteria for authorship
(2009) Sanjay Singh
[No abstract available]
Current role of trans rectal ultrasonography (TRUS) of prostate
(2001) Wani M. Saleem; P.B. Singh; U.S. Dwivedi
[No abstract available]
Cutaneous metastases of prostatic adenocarcinoma
(Wolters Kluwer Medknow Publications, 2015) Shashikant C.U. Patne; Bitan Naik; Pranab Patnaik; Sameer Trivedi
Prostatic adenocarcinoma (PA) is a common visceral malignancy of elderly men. Cutaneous metastasis of PA is rare. The incidence is <1%. A 55-year-old man presented with urinary symptoms and multiple cutaneous nodules around suprapubic region, inner aspect of both thighs and scrotum. Fine-needle aspiration cytology (FNAC) of cutaneous nodules was suggestive of metastatic adenocarcinoma. Skin and prostatic biopsies confirmed the cytological diagnosis. Serum level of prostate specific antigen was raised. Total prostatectomy revealed adenocarcinoma of Gleason's score 7 (3 + 4). Though rare, cutaneous metastases of PA must be known to cytopathologists. Meticulously performed FNAC in such cases may help in early diagnosis.
Developments and Scope of Space Food
(Bentham Science Publishers, 2022) Yashmita Grover; Jagriti Bhasin; Bhavika Dhingra; Sonali Nandi; Mamta Hansda; Ruchi Sharma; Veena Paul; Rubeka Idrishi; Abhishek Dutt Tripathi; Aparna Agarwal
Humans have conducted numerous space missions in past decades and its success depends upon many factors, including astronaut health as the major factor. Health and nutrition are two vital components of life derived from food which helps in keeping one’s body alive, nourished as well as energetic, including the astronauts during their long-duration manned missions. With the advancement in research and technology, it became possible to include a wide variety of dishes in the space menu, with most of them being similar to those eaten on the earth. This review highlights the evolution of space food starting from mission Mercury to the current International Space Station. Furthermore, it also enlightens and focuses on types of space food, its packaging considerations, and vitamin A-rich energy balls as potential space food. Many deleterious effects of outer space explorations have been observed on the human body, such as loss of body mass, vision-related changes, loss in bone density, and even anemia. To overcome these issues, various considerations must be followed while designing space food. The nutritional requirement plays an important role in a space mission. Various foods have the potential to overcome the limitations caused by a space mission. Thus, while developing space food, various parameters should be taken into consideration, such as deficiencies and illness. The food should be compact, bite-sized, easily digestible, and shelf-stable. Further research is required to better gain insight into the technological advancements while considering the nutritional status and requirements of astronauts in a space mission. © 2022 Bentham Science Publishers.