Synthesis and antimicrobial activities of N-mannich bases of 3-[4-sulphadiazinyl]-isatin and derivatives

Abstract

Isatins (1) have been condensed with sulfadiazine (2) to yield 3-sulfadiazinyisatins (3). Mannich condensation on 3 in presence of CH2O and secondary amines furnished 3-aminomethyl analogs (4) which were evaluated as antimicrobical agents.