Access to Nitrones from Amines via Electrocatalysis at Room Temperature

Abstract

A self-enabled electrooxidative protocol for the synthesis of nitrones from bench stable amines has been developed under constant current electrolysis at room temperature, rendering metal and external oxidant-free protocol in an alkaline medium. The electrocatalysis steps of reported strategy involve anodic oxidation of benzyl amines followed by cathodic reduction of nitro-functional group in an undivided cell affording functional nitrones. The robustness of the electrocatalysis was reflected by tolerant substrate scope, oxidant-free conditions, and an operationally friendly procedure. Moreover, the cyclic voltammetry and control experiment studies also support the electrochemical process in alkaline medium. (Figure presented.). © 2022 Wiley-VCH GmbH.