Urinary excretion of acid mucopolysaccharide in normal human beings and generalised musculo skeletal affections

Abstract

A study of excretion of acid mucopolysaccharide (AMPS) in normal healthy individuals and in patients with generalised musculoskeletal affections is presented. Overall normal AMPS values were found to vary in a very wide range and the figures were found to be higher as compared to Western literature, probably due to racial and dietetic factors. The AMPS excretion was found to be increased in muscular dystrophy (pseudohypertropic type), osteopetrosis, myositis ossificans progressiva, mongolism, achondroplasia, Hurler's syndrome and in 2 out of 8 cases of osteogenesis imperfecta. The excretion was found to be within normal limits in the following conditions: Pyle's disease, polyostotic fibrous dysplasia, metaphyseal aclasis, Morquio Brailsford's disease, Ollier's disease, osteopoikilosis and neurofibromatosis.