Utilizing Baylis–Hillman Adducts Followed by Michael Addition/Elimination Reaction for the Synthesis of Unusual Conformationally Stable Molecules Governed by Aromatic Interactions

Abstract

The compounds under investigation sought a new approach to synthesis via the Baylis-Hillman (B−H) and Michael addition reactions. The product formation‘s legitimacy was tested using a repeat reaction with many different nucleophiles. The additional stability of the product via aromatic π⋅⋅⋅π and C−H⋅⋅⋅π interactions may result in unexpected product formation in diverse reactions undertaken utilizing different starting materials. This study suggests that weak interaction not only provides selectivity during reactions but also modifies the result. © 2023 Wiley-VCH GmbH.