Nickel-mediated N-arylation with arylboronic acids: An avenue to Chan-Lam coupling

Abstract

An efficient use of NiCl 2·6H 2O, for the cross-coupling of arylboronic acids with various N-nucleophiles, has been demonstrated. The method is practical and offers an alternative to the corresponding Cu-mediated Chan-Lam process for the construction of the C-N bond. © 2012 American Chemical Society.