Title:
Dexamethasone-induced phosphorylation of high mobility group nonhistone proteins of aging rats

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dc.contributor.authorS. Prasad
dc.contributor.authorM.K. Thakur
dc.date.accessioned2026-02-09T09:41:10Z
dc.date.issued1987
dc.description.abstractPhosphorylation of high mobility group (HMG) proteins and its modulation by dexamethasone were examined in vitro by incubating liver slices of young (15- ) and old (138-week) male rats with (32P) orthophosphate. HMG proteins were extracted and analyzed by acid-urea polyacrylamide gel electrophoresis. Phosphorylation of HMG proteins, particularly of HMG 2, 14 and 17 decreases drastically in old rats. Dexamethasone stimulates the phosphorylation of total HMG proteins in both ages. Individual HMG proteins vary in the extent of 32P incorporation. Such differential phosphorylation of HMG proteins and its modulation by dexamethasone may affect chromatin organization and gene expression during aging. © 1987 Martinus Nijhoff Publishers.
dc.identifier.doi10.1007/BF00444679
dc.identifier.issn15734978
dc.identifier.urihttps://doi.org/10.1007/BF00444679
dc.identifier.urihttps://dl.bhu.ac.in/bhuir/handle/123456789/56012
dc.publisherMartinus Nijhoff/Dr. W. Junk Publishers
dc.subject(rat liver)
dc.subjectaging
dc.subjectdexamethasone
dc.subjecthigh mobility group proteins
dc.subjectphosphorylation
dc.titleDexamethasone-induced phosphorylation of high mobility group nonhistone proteins of aging rats
dc.typePublication
dspace.entity.typeArticle

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