Annulative Coupling of Tetrahydroisoquinolines with Aryliodonio diazo compounds to Access 1,2,4-Triazolo[3,4- a]isoquinolines

Abstract

Base promoted one-pot annulative coupling of 1,2,3,4-tetrahydroisoquinolines (THIQs) with hypervalent iodine(III) species aryliodonio diazo compounds has been devised for the direct construction of 1,2,4-triazolo[3,4-a]isoquinoline derivatives at room temperature in open air for the first time. This approach involves [2 + 3] cascade annulation of nucleophilic THIQ with an electrophilic aryliodonio diazo compound via N-H and α-C1(sp3)-H difunctionalization of THIQ. © 2022 American Chemical Society. All rights reserved.