Evaluation of anti-pyretic potential of Ichnocarpus frutescens roots

Abstract

The methanolic extract of Ichnocarpus frutescens R.Br. root (MEIF) was evaluated for its anti-pyretic potential on normal body temperature and yeast-induced pyrexia in albino rats. Yeast suspension (10 ml/kg body wt.) increased rectal temperature 19 h after subcutaneous injection. The MEIF, at doses of 100, 200, and 300 mg/kg body wt., p.o., produced significant reduction in normal body temperature and yeast-provoked elevated temperature in a dose dependent manner. The effect extended up to 5 h after the drug administration. The anti-pyretic effect of MEIF was comparable to that of paracetamol (150 mg/kg body wt., p.o.), a standard anti-pyretic agent. © 2009 by Razi Institute for Drug Research (RIDR).