Chemical constituents of Anisodus luridus roots and their antimicrobial screening

Abstract

The weak base and strong base fractions were separated from methanolic extract of roots of Anisodus luridus. Chromatographic resolution of both fractions yielded compounds 1-5 which were characterized as β-sitosterol (1), esculetin (2), β-sitosterol-β-D-glucoside (3), apohyoscyamine (4) and hyoscyamine (5) with the help of spectroscopic analysis. Four compounds, 1-4 were isolated from A. luridus for the first time. The weak base, strong base and isolated constituents were screened against six microbes viz. E. coli, S. aureus, E. faecalis, C. albicans, C. tropicalis and C. krusei. Weak base, strong base and isolated pure compounds exhibited their potential against these microbes. © 2015 Scientific Publishers.