Increased production of interleukin-1 and tumor necrosis factor by human monocytes treated in vitro with cisplatin or other biological response modifiers

Title:
Increased production of interleukin-1 and tumor necrosis factor by human monocytes treated in vitro with cisplatin or other biological response modifiers

dc.contributor.author	Ajit Sodhi
dc.contributor.author	Kalpana Pai
dc.date.accessioned	2026-02-09T09:22:37Z
dc.date.issued	1992
dc.description.abstract	Supernatants collected from cisplatin, lipopolysaccharide (LPS), muramyl dipeptide (MDP) or interferon-gamma (IFN-γ) treated human monocytes enhance the thymocyte proliferation by a submitogenic concentration of concanavalin A. Also supernatants collected from cisplatin or IFN-γ treated monocytes demonstrated enhanced cytotoxicity against actinomycin-D treated L 929 cells, suggesting that cisplatin or rIFN-γ treated monocytes release tumor necrosis factor (TNF) into the culture medium. The supernatant collected from untreated monocytes showed only little IL-1 and TNF activity. © 1992.
dc.identifier.doi	10.1016/0165-2478(92)90211-6
dc.identifier.issn	1652478
dc.identifier.uri	https://doi.org/10.1016/0165-2478(92)90211-6
dc.identifier.uri	https://dl.bhu.ac.in/bhuir/handle/123456789/54559
dc.subject	Cisplatin
dc.subject	IL-1
dc.subject	Monocyte
dc.subject	TNF
dc.title	Increased production of interleukin-1 and tumor necrosis factor by human monocytes treated in vitro with cisplatin or other biological response modifiers
dc.type	Publication
dspace.entity.type	Article