Effect of coenzyme Q10 on 50-Hz power line exposed water induced neurobehavioural alterations in rats

Abstract

Bioeffects of direct electromagnetic fields (EMF) have been studied extensively in mammalian systems and various physical and biological effect mechanisms proposed so far but none of the mechanism is widely accepted. Indirect EMF induced bio-effects through power line exposed water (restructured water) in animals are very scanty. Therefore, an attempt has been taken to study the indirect effect of EMF on neurobehavioural patterns in rats; and to measure the protective role of Coenzyme Q10 (CoQIO, a potent antioxidant) in EMF exposed subjects. In this study double distilled water samples were exposed to 50- Hz power line step -down transformer of 2500 KVA with EMF strength of 51.2 uT(36.2 RMS) for 48 hours. The EMF exposed water was made available ad libitum to E2 group while E3 group was also received similar exposed water along with intragastric intubation of CoQIO at a dose of 10 mg/kg body weight for 90 days. Unexposed distilled water was given to El group to drink ad libitum .On examination of neurobehavioural tests of anxiety and depression, significant behavioral alterations were found in EMF exposed water treated group (E2) while these neurobehavioural disturbances were substantially recovered in group E3. This study suggests that 50-Hz power line exposure induces stable changes in "biologically live" water thus affecting the biomechanics of tissue fluids which ultimately enhances the free radicals load especially in brain cells. Since Co Q10 is a potent free radical scavenger, significantly protected the functional alterations induced by EMF exposed water.