Synthesis and Evaluation of 2-Imino-3-(4-arylthiazol-2-yl)-4-thiazolidinones and Their 5-Arylidene Derivatives as Potential Fungicides

Abstract

A series of new 2-imino-3-(4-arylthiazol-2-yl)-4-thiazolidinones and their 5-arylidene derivatives have been synthesized from 2-amino-4-arylthiazoles as starting materials. The reaction mechanism has also been critically examined. Of all the synthetic compounds tested against Trichoderma harzianum and Curvularia lunata, two of them, namely 2-imino-3-(4-p-chlorophenylthiazol-2-yl)-4-thiazolidinone and 5-benzylidine-2-imino-3-(4-p-tolylthiazol-2-yl)-4-thiazolidinone, exhibited the most potent fungicidal effect. © 1991, American Chemical Society. All rights reserved.