Title:
Double Morita-Baylis-Hillman (MBH) strategy; An intermolecular and a chemo selective intramolecular MBH reactions for 5/6 substituted, functionalized piperidine unit

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dc.contributor.authorKishor Chandra Bharadwaj
dc.contributor.authorDharmendra Kumar Tiwari
dc.date.accessioned2026-02-07T08:18:40Z
dc.date.issued2016
dc.description.abstractA novel approach utilizing dual Morita-Baylis-Hillman (MBH) reactions in form of intermolecular and a chemo selective intramolecular version, has been developed. With three electrophilic and a nucleophilic site in precursor, selective condition for intramolecular MBH reaction has been optimized. Role of water was found to be crucial. The dual strategy was applicable for synthesis of a variety of medicinally and synthetically important piperidine unit whose 5/6 atoms of ring were substituted, featuring a stereo defined trisubstituted olefin, a Michael acceptor (with a methylene moiety), trivalent nitrogen and a tertiary alcohol. © 2015 Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.tet.2015.11.041
dc.identifier.issn404020
dc.identifier.urihttps://doi.org/10.1016/j.tet.2015.11.041
dc.identifier.urihttps://dl.bhu.ac.in/bhuir/handle/123456789/29564
dc.publisherElsevier Ltd
dc.subjectAcrylamide
dc.subjectDABCO
dc.subjectIntramolecular Morita-Baylis-Hillman
dc.subjectPiperidine
dc.subjectWater
dc.titleDouble Morita-Baylis-Hillman (MBH) strategy; An intermolecular and a chemo selective intramolecular MBH reactions for 5/6 substituted, functionalized piperidine unit
dc.typePublication
dspace.entity.typeArticle

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