Easy Access to α-Ketothioamides via Oxidative Amidation of Bunte Salts Using Electrolysis or Hypervalent Iodine

Abstract

Two new protocols leveraging electrochemical and hypervalent iodine-mediated synthesis of α-ketothioamides have been developed by using easily accessible and cost-effective Bunte salts and secondary amines. The methods are efficient, simple, and straightforward, and showcase the formation of C-N bonds across diverse substrates under ambient conditions. © 2024 American Chemical Society.