Further study of antiinflammatory effects of Abies pindrow

Abstract

Abies pindrow leaves are used as an Ayurvedic remedy for disorders with inflammatory symptoms. The antiinflammatory effect was established in preliminary studies. Fractional extraction of the leaves indicated uneven predominance of flavonoids, glycosides, terpenoids and steroids. An antiinflammatory effect in the 5 h carrageenin oedema model was exhibited by all fractions, indicating multiple active principles. Studies in granuloma pouch and adjuvant arthritis models in rats also indicated a significant antiinflammatory effect. The polar constituents were more inhibitory to acute, while non-polar ones prominently inhibited the chronic inflammatory reactions. No immunomodulatory effect could be indicated as such.