Title:
p53 activation and mitochondria-mediated pathway are involved during hanging deathinduced neuronal cell apoptosis in dentate gyrus region of the rat brain

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dc.contributor.authorSabana Khatun
dc.contributor.authorShail K. Chaube
dc.contributor.authorChandra N. Bhattacharyya
dc.date.accessioned2026-02-07T05:43:25Z
dc.date.issued2013
dc.description.abstractThe goal of this study was to understand the molecular event in the brain caused by hanging death (HD). Animals were subjected to either cervical dislocation (CD) or HD. Brain was collected at various times (0, 1, 3, 6 and 12 h) after death. Brain expression of p53 and Bax, cytochrome c concentration, caspases activity and DNA fragmentation were analyzed. Compared to that of CD, HD increased p53 and Bax proteins expressions, cytochrome c concentration, caspases activity and DNA fragmentation during the early period (0-6 h) of HD, whereas CD induced necrosis 3 h post- CD and thereafter. These data support that HD induces neuronal cell apoptosis, in part, through mitochondria-mediated pathways. These data also suggest that neuronal apoptosis could be a potential marker and an aid to forensic science of HD. © 2013 Khatun et al.
dc.identifier.doi10.1186/2193-1801-2-407
dc.identifier.issn21931801
dc.identifier.urihttps://doi.org/10.1186/2193-1801-2-407
dc.identifier.urihttps://dl.bhu.ac.in/bhuir/handle/123456789/25616
dc.publisherSpringerOpen
dc.subjectApoptosis
dc.subjectCaspases activity
dc.subjectCytochrome c
dc.subjectForensic science
dc.subjectHanging death
dc.subjectNecrosis
dc.subjectNeuronal cells
dc.subjectp53
dc.titlep53 activation and mitochondria-mediated pathway are involved during hanging deathinduced neuronal cell apoptosis in dentate gyrus region of the rat brain
dc.typePublication
dspace.entity.typeArticle

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