DMAP-promoted domino annulation of β-ketothioamides with internal alkynes: A highly regioselective access to functionalized 1,3-thiazolidin-4-ones at room temperature

Abstract

DMAP-mediated rapid and efficient one-pot regioselective access to functionalized 1,3-thiazolidin-4-ones via annulation of β-ketothioamides with internal alkynes has been achieved under mild reaction conditions. The merit of this straightforward domino protocol is highlighted by its operational simplicity, short reaction time, tolerance of a large variety of functional groups, and efficiency of producing two new bonds (C-S and C-N) and one thiazolidine ring. © The Royal Society of Chemistry 2014.