Improvised strategy of ethanolic nanovesicular gel of phospholipon 90G for transdermal delivery of luliconazole to mitigate fungal diseases

Abstract

The research work involves the development and characterization of ethanolic nanovesicular gel of different concentrations of the specified chemicals so as to estimate the optimized one among the rest. For the determination of its stability and suitability, optimized formulation was carried to a number of evaluation parameters such as particle size, zeta potential, polydispersity index (PDI), % entrapment efficiency (%EE), attenuated total internal reflection Fourier transforms infra-red spectroscopy (ATR-FTIR), transmission electron microscopy (TEM), atomic force microscopy (AFM), in vitro drug permeation study, stability studies, viscosity, pH, spreadability, extrudability, and last but not least, anti-fungal activity done by considering tube dilution assay. And finally, the results obtained were recorded and analyzed for all the parameters. The outcomes revealed that among nine nanovesicular formulations, ENV5 was found to be optimized, as because of its appropriate results for particle size, PDI, and zeta potential and highest % entrapment efficiency of about 169.5 nm, 0.407, −37.9 mV, and 80.07 ± 0.55% respectively, whereas in vitro drug permeation study expresses % cumulative release of 78.59 ± 0.43 in about 24 h. The suspension of nanovesicular system and lyophilized form of nanovesicular suspension both were examined and found to be very much stable at 4°C/60 ± 5 % RH than that of 25 °C/60 ± 5 % RH. Ultimately, the outcomes of the evaluation parameters have proved that the buildup is stable and suitable for topical application hence, leading to efficacious therapy of fungal diseases. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.