Title:
In vitro evaluation of Bacopa monniera on anti-Helicobacter pylori activity and accumulation of prostaglandins

Simple item page
dc.contributor.authorR.K. Goel
dc.contributor.authorK. Sairam
dc.contributor.authorM. Dora Babu
dc.contributor.authorI.A. Tavares
dc.contributor.authorA. Raman
dc.date.accessioned2026-02-06T10:41:10Z
dc.date.issued2003
dc.description.abstractBacopa monniera is an Indian tratidional medicine widely used to improve intellectual functions. Earlier, we had reported the prophylactic and curative effects of standardized extract of Bacopa monniera (BME) in various gastric ulcer models. The effect was due to augmentation of the defensive mucosal factors like increase in mucin secretion, life span of mucosal cells and gastric antioxidant effect rather than on the offensive acid-pepsin secretion. The present study includes evaluation of standardized BME (bacoside A content - 35.5 ± 0.9) on other contributing factors towards ulcerogenesis. BME in the dose of 1000 μg/ml showed anti-Helicobacter pylori activity in vitro I and in the dose of 10 μg/ml increased in vitro of prostanoids (PGE and PGI2) in human colonic mucosal incubates. It may be concluded that these factors may contribute to antiulcerogenic activity of BME.
dc.identifier.doi10.1078/094471103322331494
dc.identifier.issn9447113
dc.identifier.urihttps://doi.org/10.1078/094471103322331494
dc.identifier.urihttps://dl.bhu.ac.in/bhuir/handle/123456789/17716
dc.publisherUrban und Fischer Verlag Jena
dc.subjectAntiulcerogenic
dc.subjectBacopa monniera
dc.subjectBacoside-A
dc.subjectGastric mucosal offensive and defensive factors
dc.subjectHelicobacter pylori
dc.subjectProstaglandins
dc.titleIn vitro evaluation of Bacopa monniera on anti-Helicobacter pylori activity and accumulation of prostaglandins
dc.typePublication
dspace.entity.typeArticle

Files

Collections

2003
An Initiative by BHU – Central Library
Powered by Dspace