Role of -460 C/T VEGF gene polymorphism in preeclampsia

Abstract

Objective: To study association of VEGF-460C>T functional polymorphism with preeclampsia. Methods: The case-control study comprised of two groups: 40 pre-eclamsia patients and 45 healthy antenatal women. Genotyping for SNP-460 VEGF was done by ARMS-PCR method. For VEGF-460C>T functional polymorphism, allele and genotype distribution were evaluated using Chi-square test. Results: The prevalence of C allele was higher among cases compared to controls. The prevalence of CT and CC genotypes were also higher among cases compared to controls indicating that CT and CC genotypes and C allele to have a role in genetic susceptibility for preeclampsia. Conclusions: The carriage of VEGF-460C allele appears to be a risk factor for preeclampsia in present pilot study. © 2013 Hainan Medical College.