Dose finding study of sahaj vati (Comprised of Shilajeet, Haridra, Guggul and Chitrak) in validated animal model of obesity

Abstract

Efficacy of Sahaj Vati containing Shilajeet, Guggul, Haridra and Chitrak has been evaluated at dose of 100, 200 and 400 mg/kg body weight after screening the appropriate diet induced obesity model (monosodium glutamate and cafeteria diet induced). It has been observed that both monosodium glutamate and cafeteria diet increases body weight but cafeteria diet also causes dyslipidemia. At the dose of 400 mg/kg, body weight of animal was significantly decreased with increased total cholesterol, low-density lipoprotein and triglycerides and insignificant decrease of body weight occurs at dose of 100 mg/kg along with increased triglycerides. At the dose of 200 mg/kg body weight was significantly decreased along with the significant increase of high-density lipoprotein and insignificant decrease in very low-density lipoprotein, low-density lipoprotein, and triglycerides. On the basis of present finding we conclude that monosodium glutamate is more suitable for induction of obesity whereas cafeteria diet for obesity associated with dyslipidemia and Sahaj Vati at the dose of 200 mg/kg body weight is more appropriate for reduction of body weight. © 2018, National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved.