Title: Synthesis, molecular docking and Brugia malayi thymidylate kinase (BmTMK) enzyme inhibition study of novel derivatives of [6]-shogaol
| dc.contributor.author | Vinay Kr Singh | |
| dc.contributor.author | Pawan K. Doharey | |
| dc.contributor.author | Vikash Kumar | |
| dc.contributor.author | J.K. Saxena | |
| dc.contributor.author | M.I. Siddiqi | |
| dc.contributor.author | Sushma Rathaur | |
| dc.contributor.author | Tadigoppula Narender | |
| dc.date.accessioned | 2026-02-07T06:11:45Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | [6]-Shogaol (1) was isolated from Zingiber officinale. Twelve novel compounds have been synthesized and evaluated for their Brugia malayi thymidylate kinase (BmTMK) inhibition activity, which plays important role for the DNA synthesis in parasite. [6]-Shogaol (1) and shogaol with thymine head group (2), 5-bromouracil head group (3), adenine head group (4) and 2-amino-3-methylpyridine head group (5) showed potential inhibitory effect on BmTMK activity. Further molecular docking studies were carried out to explore the putative binding mode of compounds 1-5. © 2015 Elsevier Masson SAS. | |
| dc.identifier.doi | 10.1016/j.ejmech.2015.01.035 | |
| dc.identifier.issn | 2235234 | |
| dc.identifier.uri | https://doi.org/10.1016/j.ejmech.2015.01.035 | |
| dc.identifier.uri | https://dl.bhu.ac.in/bhuir/handle/123456789/27961 | |
| dc.publisher | Elsevier Masson SAS | |
| dc.subject | Brugia malayi | |
| dc.subject | Enzyme inhibitor | |
| dc.subject | Filariasis | |
| dc.subject | Molecular modelling | |
| dc.subject | Thymidylate kinase | |
| dc.subject | Zingiber officinale | |
| dc.subject | [6]-Shogaol | |
| dc.title | Synthesis, molecular docking and Brugia malayi thymidylate kinase (BmTMK) enzyme inhibition study of novel derivatives of [6]-shogaol | |
| dc.type | Publication | |
| dspace.entity.type | Article |