Synthesis of 1-aryl-2-mercapto-4-aryl-1,6-dihydro-1,3,5-triazine-6-thione and their latentiation products as antithyroidal agent

Abstract

Two new 1-aryl-2-benzylmercapto-4-aryl-1,6-dihydro-1,3,5-triazine-6-thiones have been synthesized by known methods (Goerdeler et al., 1967). These triazines on treatment with thiourea as dealkylating agent, in acidic medium afforded the corresponding 1-aryl-2-mercapto-4-aryl-1,6-dihydro-1,3,5-triazine-6-thione whch on further reaction with different α, β-unsaturated carbonyl compounds and aryl-cyanamide hydrochloride afforded the related adducts. Some of these compounds show appreciable antithyroidal activity. © 1995 The Pharmaceutical Society of Korea.