Evaluation of some acylamide derivatives as potential hypoglycemic agents

Abstract

A series of new acylamide derivatives with piperidine, pyrrolidinyl and alanyl have been tested for their hypoglycemic activities. 2-(Pyrrolidinyl)-N-(3-chlorophenyl) acetamide and 2-(Piperazinyl)-N-(4-methoxy phenyl) acetamide were found to be the most active hypoglycemic compounds. Probably the amides have mode of action similar to sulphonylureas.