Title: Dichotosin and dichotosinin, two adaptogenic glucosyloxy flavans from Hoppea dichotoma
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Abstract
From the roots of Hoppea dichotoma, collected before flowering, two new naturally occurring glucosyloxyflavans, dichotosin and dichotosinin, have been isolated and characterized by means of comprehensive spectral analyses, chemical transformation and synthesis of the aglucone of dichotosin. This is the first report of dichotosinin from a natural source. Additionally, one known glucosyloxyflavan, diffutin, earlier reported in another Gentianaceae species (Canscora diffusa) also has now been isolated from this species. The glucosyloxyflavans, individually and in combination, produced varying degrees of adaptogenic (anti-stress-anti-anxiety) activity in animal models. This observation is consistent with the use of the plant extract as a nerve tonic in Ayurvedic medicine. © 1985.
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Keywords
7,3′,4′-trimethoxy-5-O-β-d-glucopyranosylflavan, 7-hydroxy-3′,4′-dimethoxy-5-O-β-d-glucopyranosylflavan, central nervous sytem (CNS) active agents adaptogens., dichotosin, (2S)-7,4′-dimethoxy-5-O-β-d-glucupyranosylflavan, dichotosinin, diffutin, Gentianaceae, roots, glucosyloxy flavans, Hoppea dichotoma