Title:
Design, synthesis, docking and anti-inflammatory evaluation of novel series of benzofuran based prodrugs

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dc.contributor.authorPratima Yadav
dc.contributor.authorPraveen Singh
dc.contributor.authorAshish Kumar Tewari
dc.date.accessioned2026-02-07T06:00:24Z
dc.date.issued2014
dc.description.abstractSeveral new benzofuran derivatives were synthesized, via appropriate synthetic route as anti-inflammatory agents. The anti-inflammatory activity of the prepared compounds was evaluated using carrageenan rat model. Among the synthesized compounds, some compounds showed comparable anti-inflammatory activity to nimesulide, the standard drug taken for anti-inflammatory studies. Docking study of the prepared compounds was performed for the study of interaction of molecules with the active site of COX-2. Preliminary biological studies and docking gave an interesting insight, into the validity of employing benzofuran analogues as good anti-inflammatory agent. © 2014 Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.bmcl.2014.03.087
dc.identifier.issn0960894X
dc.identifier.urihttps://doi.org/10.1016/j.bmcl.2014.03.087
dc.identifier.urihttps://dl.bhu.ac.in/bhuir/handle/123456789/26215
dc.publisherElsevier Ltd
dc.subjectAnti-inflammatory
dc.subjectBenzofurans
dc.subjectDrug design
dc.subjectInflammation
dc.subjectMolecular modeling
dc.titleDesign, synthesis, docking and anti-inflammatory evaluation of novel series of benzofuran based prodrugs
dc.typePublication
dspace.entity.typeArticle

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