Microwave-Assisted Copper-Catalyzed Synthesis of Triazole-linked 2-Amino-Pyrimidinone based Glycohybrids

Abstract

2-Amino pyrimidines are vital molecules that exhibit diverse biological activities and serve as structural motifs in various pharmaceutical drugs. Four new series of triazole-linked glycohybrids of 2-amino-pyrimidinones were designed and efficiently synthesized, using a microwave-assisted method under click chemistry reaction conditions. The N-propargyl-2-aminopyrimidinone and O-propargyl-2-aminopyrimidine derivatives successfully underwent the click reactions with 1-azido-tetra-O-acetyl-β-D-glucose, D-galactose and D-mannose. In this work, we reported the series of novel thirty-three new triazole-linked glycohybrid molecules with stereochemical diversity and diverse substitution patterns. © 2024 Wiley-VCH GmbH.