Experimental production of thyrotoxicosis

Abstract

The role of emotional stress in thyrotoxicosis has been studied in female rats exposed to continuous emotional stress for 8 days by keeping them in front of dog cages. Marked epithelial proliferation in the first 2 weeks, followed by lymphocytic infiltration in the next 2 weeks, results in the typical histological picture of thyrotoxicosis. Elevated serum protein bound iodine, T 3 resine uptake and 131I uptake and lowered serum cholesterol level confirm the thyrotoxicosis.