Photoredox Catalyzed Cyclization of Enaminones/Ketene N,S-Acetals with β-Ketodinitriles to Access Polysubstituted Pyrroles

Abstract

A facile synthesis of polyfunctionalized pyrroles has been explored via photoredox cascade cyclization of enaminones/ketene N,S-acetals with β-ketodinitriles using eosin Y, CuI, and Ag<inf>2</inf>CO<inf>3</inf>in acetonitrile under blue LED irradiation at room temperature. The present report offers an efficient and straightforward approach to pyrrole-3-carboxylic acids and pyrrole-3-carboxamides with wide substrate scope and functional group tolerance. © 2025 American Chemical Society