An efficient tetrabutylammonium fluoride (TBAF)-catalyzed three-component synthesis of 3-substituted indole derivatives under solvent-free conditions

Abstract

An expedient and efficient one-pot three-component synthesis of 3-substituted indoles has been developed by the reaction of indoles, active methylene compounds and aldehydes using a catalytic amount of tetrabutylammonium fluoride under solvent-free conditions. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.