Metabolic changes in the tissues of young and old mice. Oxygen consumption with different substrates

Abstract

Oxidation of malate, glutamate and arginine by the kidney cortex, brain and heart of 17- and 70-week-old mice were studied manometrically. A higher rate of oxidation of malate in all the three tissues was observed indicating an apparent increase in the activity of malic dehydrogenase in old age. The increased rate of oxidation of glutamate in kidney cortex also shows an increase in the activity of glutamic dehydrogenase in this tissue. There was no noticeable change in the oxidation of glutamate by the brain of young and old mice. © 1968.