Mitsunobu reaction of 1,3-dicarbonyl compounds and subsequent Pd-catalyzed intramolecular arylation: An expedient route to tricyclic oxoisochromenes

Abstract

1,3-Dicarbonyl compounds undergo chemoselective O-alkylation with (2-bromoaryl)methanols under Mitsunobu conditions at ambient temperature generating corresponding vinyl ethers in high yields. These vinyl ethers can be subsequently converted into tricyclic oxoisochromenes via previously reported ligand-free Pd-catalyzed intramolecular arylation reaction. © 2025 Elsevier Ltd