Intracerebroventricularly administered bradykinin augments carrageenan‐induced paw oedema in rats

Abstract

Abstract— Intracerebroventricular (i.e.v.) administered bradykinin (2.5 and 5.0 μg/rat) was found to augment carrageenan‐induced acute paw oedema throughout the 4 h post‐carrageenan observation period. The effect was statistically significant with the higher dose. The pro‐inflammatory effect of i.c.v. bradykinin was antagonized following pretreatment with hemicholinium and atropine ethoiodide administered i.c.v., drugs that reduce central cholinergic activity. Similarly, central administration of drugs that inhibit the synthesis of eicosanoids, hydrocortisone, diclofenac and paracetamol, also attenuated the pro‐inflammatory effect of bradykinin. The findings indicate that the inflammation‐promoting effect of centrally administered bradykinin involves the central prostaglandin and cholinergic neurotransmitter systems. 1988 Royal Pharmaceutical Society of Great Britain