Prevalence of methylenetetrahydrofolate reductase C677T polymorphism

Abstract

This study evaluates the frequency of 5, 10-methylenetetrahydrofolate reductase (MTHFR) C677T mutation in eastern Uttar Pradesh population (UP). PCR-RFLP method was used for the detection of C677T mutation. In total 139 subjects were analyzed for the MTHFR C677T polymorphism. Genotype frequencies of CC, CT and TT were found to be 0.928, 0.065 and 0.007 respectively. The frequency of T allele was 0.039. ©IJIB, All rights reserved.