Title: Age-dependent decrease in the interaction of β-tubulin with estrogen receptor alpha transactivation domain in mouse brain
| dc.contributor.author | Swati Ghosh | |
| dc.contributor.author | M.K. Thakur | |
| dc.date.accessioned | 2026-02-07T04:52:50Z | |
| dc.date.issued | 2009 | |
| dc.description.abstract | In the previous paper, we reported that four proteins of 100 kDa, 80 kDa, 68 kDa and 50 kDa from the mouse brain interacted with estrogen receptor (ER) α-transactivation domain (TAD) and 68 kDa protein showed age and sex dependent changes. Here, we describe the identification of 50 kDa protein as β-tubulin and changes in its interaction with age and sex in mouse brain. It is a microtubule-associated protein which binds to activation function (AF)-1 region of ERα-TAD and is involved in estrogen signaling. The extent of interaction of mouse ERα-TAD with β-tubulin was higher in adult female as compared to old female and adult male. However, the expression of β-tubulin showed no significant change with age and sex. Such age and sex dependent alteration in the interaction of β-tubulin might account for the estrogen-mediated brain functions during aging. © 2009 Elsevier Ireland Ltd. All rights reserved. | |
| dc.identifier.doi | 10.1016/j.neulet.2009.08.054 | |
| dc.identifier.issn | 3043940 | |
| dc.identifier.uri | https://doi.org/10.1016/j.neulet.2009.08.054 | |
| dc.identifier.uri | https://dl.bhu.ac.in/bhuir/handle/123456789/20560 | |
| dc.subject | β-Tubulin expression | |
| dc.subject | Aging | |
| dc.subject | Brain | |
| dc.subject | Estrogen receptor | |
| dc.subject | Protein interaction | |
| dc.title | Age-dependent decrease in the interaction of β-tubulin with estrogen receptor alpha transactivation domain in mouse brain | |
| dc.type | Publication | |
| dspace.entity.type | Article |