Decarboxylative thioamidation of arylacetic and cinnamic acids: A new approach to thioamides

Abstract

A new decarboxylative strategy has been developed for the synthesis of thioamides via a three-component reaction involving arylacetic or cinnamic acids, amines and elemental sulfur powder, without the need of a transition metal and an external oxidant. © 2014 American Chemical Society.