Inhibitory response of drug resistant bacteria towards methanol extract of Piper longum L. fruit

Abstract

Plant extract could be a potential source of compounds usable against antibiotic resistant pathogenic bacteria because of structurally novelty from traditionally used microorganisms with high stability and activity in extreme conditions. The activity of different solvent extracts of Piper longum L. fruit on some selected pathogenic drug resistant bacterial strains were weight up. The fruit extracts were evaluated against four gram positive and four gram negative pathogenic bacteria by Disk diffusion method. Fruit extracted in methanol, chloroform and hexane were effective against all tested bacterial strains however, methanol extract showed relatively better antibacterial activity against most of the tested bacterial strains. Methanol extract of Piper longum L. fruit also showed excellent antibacterial activity against hospital isolates Pseudomonas aeruginosaR, Salmonella typhiR and Staphylococcus aureusR which were resistant to Oflaxacine. The present work will be a pioneer approach towards solving the most challenging problem of antibiotic therapy i.e. developing resistance in bacterial pathogens against commonly and currently used antibiotics.